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Neurofilaments: A Review and Update

  • Chapter
Alterations in the Neuronal Cytoskeleton in Alzheimer Disease

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 34))

Abstract

For decades neuroanatomists have been familiar with a distinctive fibrillar appearance of large mammalian axons after treatment of nervous tissue with various silver stains. These structures were aptly referred to as “neurofibrils.” It was only relatively recently through combined efforts utilizing electron microscopic, biochemical, and immunological methodologies that these well-known structures have been more precisely defined and characterized. Today we refer to these “neurofibrils” as neurofilaments. The goal of this chapter is to review our current knowledge and understanding of neurofilaments in the context of normal cell function.

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  1. Department of Pharmacology, New York University School of Medicine, New York, N.Y., USA

    Steven S. M. Chin & Ronald K. H. Liem

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  1. Steven S. M. Chin
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  2. Ronald K. H. Liem
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  1. Case Western Reserve University, Cleveland, Ohio, USA

    George Perry

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© 1987 Plenum Press, New York

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Chin, S.S.M., Liem, R.K.H. (1987). Neurofilaments: A Review and Update. In: Perry, G. (eds) Alterations in the Neuronal Cytoskeleton in Alzheimer Disease. Advances in Behavioral Biology, vol 34. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1657-2_1

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