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Lethal Arrhythmias Resulting from Myocardial Ischemia and Infarction pp 77–90Cite as

Ischemia and Na+/K+ Pump Function

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 94))

Abstract

Passive sodium influx into rhythmically active heart cells occurs via a variety of parallel transmembrane pathways, such as membrane channels responsible for the upstroke of the action potential and ion exchange systems involved in the regulation of intracellular calcium and H+. During steady state, the cellular sodium load is counterbalanced by the energy-dependent sarcolemmal Na+/K+ pump, which extrudes sodium and imports potassium ions against an electrochemical gradient (figure 6–1).

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Authors
  1. André G. Kléber
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  2. Wayne E. Cascio
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, P&S 7-517, New York, 10032, New York, USA

    Michael R. Rosen M.D. (Professor of Pharmacology and Pediatrics) (Professor of Pharmacology and Pediatrics)

  2. Rappaport Family Institute for Research in the Medical Sciences, Technion-Israel Institute of Technology, Efron Street, Post Office Box 9697, Haifa, 31096, Israel

    Yoram Palti M.D., Ph.D. (Director) (Director)

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© 1989 Kluwer Academic Publishers, Boston/Dordrecht/London

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Kléber, A.G., Cascio, W.E. (1989). Ischemia and Na+/K+ Pump Function. In: Rosen, M.R., Palti, Y. (eds) Lethal Arrhythmias Resulting from Myocardial Ischemia and Infarction. Developments in Cardiovascular Medicine, vol 94. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1649-7_6

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  • DOI: https://doi.org/10.1007/978-1-4613-1649-7_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8916-6

  • Online ISBN: 978-1-4613-1649-7

  • eBook Packages: Springer Book Archive

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