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Repetitive Activity: Origin of the Na+ Load and its Physiologic Effects

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Lethal Arrhythmias Resulting from Myocardial Ischemia and Infarction

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 94))

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Abstract

At a constant heart rate, the heart is in a steady state. This means that with each beat the Na+, Ca2+, and K+, which cross the membrane during each action potential, must be returned to their original site inside or outside the cell before the next beat. An obvious corollary of this steady state is that the concentrations of each of these ions in each intracellular and extracellular compartment remains unaltered.

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Authors
  1. Ira S. Cohen
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  2. Fang Chang
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  3. Richard P. Kline
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, P&S 7-517, New York, 10032, New York, USA

    Michael R. Rosen M.D. (Professor of Pharmacology and Pediatrics) (Professor of Pharmacology and Pediatrics)

  2. Rappaport Family Institute for Research in the Medical Sciences, Technion-Israel Institute of Technology, Efron Street, Post Office Box 9697, Haifa, 31096, Israel

    Yoram Palti M.D., Ph.D. (Director) (Director)

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© 1989 Kluwer Academic Publishers, Boston/Dordrecht/London

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Cohen, I.S., Chang, F., Kline, R.P. (1989). Repetitive Activity: Origin of the Na+ Load and its Physiologic Effects. In: Rosen, M.R., Palti, Y. (eds) Lethal Arrhythmias Resulting from Myocardial Ischemia and Infarction. Developments in Cardiovascular Medicine, vol 94. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1649-7_3

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  • DOI: https://doi.org/10.1007/978-1-4613-1649-7_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8916-6

  • Online ISBN: 978-1-4613-1649-7

  • eBook Packages: Springer Book Archive

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