The Value of Programmed Electrical Stimulation in Triggered Activity-Induced Arrhythmias
Triggered activity induced by delayed afterdepolarizations has been investigated extensively in tissues isolated from different sites in the heart and from different species. In spite of this we still do not know the clinical relevance of this arrhythmogenic mechanism. An answer to this question is important because the ability to identify mechanisms in the clinical situation can improve our understanding of pathophysiology and provide new treatments. Presently, different methods are used to discriminate among mechanisms of arrhythmias, including electrical stimulation , antiarrhythmic drugs, and recording of monophasic action potentials. Unfortunately no method has proven to be sufficiently sensitive or specific [2, 3].
KeywordsFormalin Toxicity Doxorubicin Catecholamine Rosen
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