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Role of Cytosolic Calcium in the Normal and Ischemic Heart: Potential New Insights from the Second Generation Indicator, Indo-1

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Lethal Arrhythmias Resulting from Myocardial Ischemia and Infarction

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 94))

Abstract

A pivotal issue in the understanding of myocardial ischemia is the role played by cytosolic calcium ions. In addition to their well-known role in excitation-contraction coupling, calcium ions regulate several different ionic currents that flow across the cell membrane. Inability of the ischemic myocardium to sequester or extrude calcium could have a variety of effects, the most serious of which would be the subversion of electrical activity in the nonischemic portion of the heart through the genesis of ventricular arrhythmias.

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Authors
  1. William T. Clusin
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  2. Rajendra Mohabir
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  3. Hon-Chi Lee
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, P&S 7-517, New York, 10032, New York, USA

    Michael R. Rosen M.D. (Professor of Pharmacology and Pediatrics) (Professor of Pharmacology and Pediatrics)

  2. Rappaport Family Institute for Research in the Medical Sciences, Technion-Israel Institute of Technology, Efron Street, Post Office Box 9697, Haifa, 31096, Israel

    Yoram Palti M.D., Ph.D. (Director) (Director)

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© 1989 Kluwer Academic Publishers, Boston/Dordrecht/London

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Clusin, W.T., Mohabir, R., Lee, HC. (1989). Role of Cytosolic Calcium in the Normal and Ischemic Heart: Potential New Insights from the Second Generation Indicator, Indo-1. In: Rosen, M.R., Palti, Y. (eds) Lethal Arrhythmias Resulting from Myocardial Ischemia and Infarction. Developments in Cardiovascular Medicine, vol 94. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1649-7_2

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  • DOI: https://doi.org/10.1007/978-1-4613-1649-7_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8916-6

  • Online ISBN: 978-1-4613-1649-7

  • eBook Packages: Springer Book Archive

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