Receptor Mechanisms in Ischemia and Infarction
The autonomic nervous system, consisting of the sympathetic and parasympathetic limbs, is the most important system extrinsic to the heart for regulating cardiac function. Much has been learned in the last few years about the molecular mechanisms by which the autonomic nervous system regulates the heart. The components of the autonomic nervous system that regulate the heart include sympathetic and vagal nerve terminals, beta-adrenergic and muscarinic receptors, a transmembrane signal transduction system, protein kinases that phosphorylate various proteins within the myocardial cell, and the proteins themselves whose functions are altered when they are phosphorylated [1–6]. For discussion of regulation and interaction at the level of sympathetic and vagal nerves, see the chapter by Levy in this volume.
KeywordsAutonomic Nervous System Adenylate Cyclase Muscarinic Receptor Adenylate Cyclase Activity Positive Inotropic Effect
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