Skip to main content

Taurine and NaCl: Untoward Effects and a Possible Role for the Heart

  • Chapter
Taurine and the Heart

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 93))

  • 57 Accesses

Abstract

Taurine (2-aminoethanesulfonic acid) is ubiquitous in mammalian tissues [1], but its function(s) has yet to be elucidated fully. That it is able to influence electrolyte distribution, especially in excitable tissues, has long been known [2–4], as has its role in osmoregulation in mammals [5] and lower animals [6]. Taurine has been shown to have beneficial effects in certain disease models involving fluid and electrolyte imbalances [7,8].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Jacobsen JG, Smith LH, Jr. 1968. Biochemistry and physiology of taurine and taurine derivatives. Physiol Rev, 48:424–511.

    PubMed  CAS  Google Scholar 

  2. McBroom MJ, WeltyJD. 1977. Effects of taurine on heart calcium in the cardiomyopathic hamster. J Molec Cell Cardiol 9:853–858.

    Article  CAS  Google Scholar 

  3. Read WO, Welty JD. 1965. Taurine as a regulator of cell potassium in the heart. Electrolytes Cardiovasc Dis 1:70–85.

    CAS  Google Scholar 

  4. Welty JD, McBroom MJ, Appelt AW, Peterson MB, Read WO. 1976. Effect of taurine on heart and brain electrolyte imbalances. In Taurine, Huxtable R, Barbeau A, eds. New York: Raven Press, pp 155–163.

    Google Scholar 

  5. Wright CE, Tallan HH, Lin YY. 1986. Taurine: Biological update. Ann Rev Biochem 55:427–453.

    Article  PubMed  CAS  Google Scholar 

  6. van Gelder NM, Barbeau A. 1985. The osmoregulatory function of taurine and glutamic acid. In Taurine, biological actions and clinical perspectives, Oja SS, Ahtee L, Kontro P, Paasonen MK, eds. New York: Alan R. Liss, pp 149–163.

    Google Scholar 

  7. Inoue A, Takahashi H, Lee L-C, Sasaki S, Takeda K, Yoshimura M, Nakagawa M, Ijichi H. 1986. Hypotensive responses to centrally administered taurine in DOCA-salt hypertensive and spontaneously hypertensive rats. Jpn Cire J 50:1215–1223.

    Article  CAS  Google Scholar 

  8. Takihara K, Azuma J, Awata N, Ohta H, Hamaguchi T, Sawamura A, Tanaka Y, Kishimoto S, Sperelakis N. 1986. Beneficial effect of taurine in rabbits with chronic congestive heart failure. Am Heart J 112:1278–1284.

    Article  PubMed  CAS  Google Scholar 

  9. Dlouha H, McBroom MJ. 1986. Atrial natriuretic factor in taurine-treated normal and cardiomyopathic hamsters. Proc Soc Exp Biol Med 181:411–415.

    PubMed  CAS  Google Scholar 

  10. Welty MC, Welty JD, McBroom MJ. 1982. Effect of isoproterenol and taurine on heart calcium in normal and cardiomyopathic hamsters. J Molec Cell Cardiol 14:353–357.

    Article  CAS  Google Scholar 

  11. Dlouha H, Krecek J. 1986. Hypernatremia in taurine and saline drinking rats—Any link to atrial natriuretic factor (ANF)? Fed Proc 45(4): 1023.

    Google Scholar 

  12. Krecek J, Dlouha H. 1986. Taurine induced Hypernatremia: The effect of natriuretic factor in prepubertal rats. Fed Proc 45(4): 1023.

    Google Scholar 

  13. Al-Kady MM. 1986. The effect of drinking taurine and NaCl solutions on the volume and composition of blood in young and adult rats. (M Sc Thesis) Kuwait University College of Graduate Studies, Kuwait.

    Google Scholar 

  14. McBroom MJ, Dlouha H. 1986. Age-related responses of Syrian hamsters to hypernatremia induced by taurine + NaCl: The possible role of atrial natriuretic factor. Age 9(4):116.

    Google Scholar 

  15. Gutkowska J, Bonan R, Roy D, Bourassa M, Garcia R, Thibault G, Genest J, Cantin M. 1986. Atrial natriuretic factor in human plasma. Biochem Biophys Res Commun 139:287–295.

    Article  PubMed  CAS  Google Scholar 

  16. Juppner H, Brabant G, Kapteina U, Kirschner M, Klein H, Hesch RD. 1986. Direct radioimmunoassay for human atrial natriuretic peptide (hANP) and its clinical evaluation. Biochem Biophys Res Commun 139:1215–1223.

    Article  PubMed  CAS  Google Scholar 

  17. Mueller GP, Horn GJ, Haddy FJ, Pamnani MB. 1985. Regional distribution of immunoreactive atriopeptin III (iAP III) in the rat. Fed Proc 44:1728.

    Google Scholar 

  18. Genest J, Cantin M. 1987. Atrial natriuretic factor. Circulation 75(Suppl. I):I-118–1-124.

    CAS  Google Scholar 

  19. Clough DL, Pamnani MB, Haddy FJ. 1983. Decreased myocardial Na+,K+-ATPase activity in one-kidney, one-clip hypertensive rats. Am J Physiol 245:H244–H251.

    PubMed  CAS  Google Scholar 

  20. Clough DL, Pamnani MB, Haddy FJ. 1984. Myocardial Na+,K+-ATPase activity in rats with steroid and spontaneous hypertension. J Hyperten 2:141–147.

    Article  CAS  Google Scholar 

  21. Fiske CH, SubbaRow Y. 1925. The colorimetric determination of phosphorus. J Biol Chem 66:375–400.

    CAS  Google Scholar 

  22. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with folin phenol reagent. J Biol Chem 193:265–275.

    PubMed  CAS  Google Scholar 

  23. Schmidt CLA, von Adelung E, Watson T. 1918. On the elimination of taurine administered to man. J Biol Chem 33:501–503.

    CAS  Google Scholar 

  24. Sturman JA, Hayes KC. The biology of taurine in nutrition and development. In Advances in nutritional research, vol. 3, Draper HH, ed. New York: Plenum Press, pp 231–299.

    Google Scholar 

  25. Wald H, Scherzer P, Popovtzer MM. 1985. Parallel changes in red blood cell and renal Na-K-ATPase activity in adrenal and electrolyte disorders in the rat. Pflugers Arch 404:56–60.

    Article  PubMed  CAS  Google Scholar 

  26. Fujita T, Sato Y. 1986. Changes in blood pressure and extracellular fluid with taurine in DOCA-salt rats. Am J Physiol 250:R1014–R1020.

    PubMed  CAS  Google Scholar 

  27. Fujita T, Sato Y, Ando K. 1986. Changes in cardiac and hypothalamic noradrenergic activity with taurine in DOCA-salt rats. Am J Physiol 251:H926–H933.

    PubMed  CAS  Google Scholar 

  28. Sato Y, Ando K, Fujita T. 1987. Role of sympathetic nervous system in hypotensive action of taurine in DOCA-salt rats. Hypertension 9:81–87.

    PubMed  CAS  Google Scholar 

  29. Dzau VJ, Baxter JD, Cantin M, deBold A, Ganten D, Gross K, Husain A, Inagami T, Menard J, Poole, S, Robertson JIS, Tang J, Yamamoto K. 1987. Nomenclature for atrial peptides. N Engl J Med 316:1278–1279.

    Article  PubMed  CAS  Google Scholar 

  30. deBold AJ, Borenstein HB, Veress AT, Sonnenberg H. 1981. A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Life Sci 28:89–94.

    Article  CAS  Google Scholar 

  31. Sonnenberg H. 1987. On the physiological role of atrial natriuretic factor. Klin Wochenschr 65(Suppl. VIII):8–13.

    PubMed  CAS  Google Scholar 

  32. Haddy FJ, Pamnani MB. 1987. Natriuretic factors in arterial hypertension. In Atrial hormones and other natriuretic factors, Mulrow PJ, Schrier R, eds. Maryland: American Physiological Society, pp 157–171.

    Google Scholar 

  33. Espiner EA, Nicholls MG. 1987. Human atrial natriuretic peptide. Clin Endocrin 26:637–650.

    Article  CAS  Google Scholar 

  34. Katsube N, Schwartz D, Needleman P. 1986. Atriopeptin turnover: Quantitative relationship between in vivo changes in plasma levels and atrial content. J Pharmacol Exp Ther 239: 474–479.

    PubMed  CAS  Google Scholar 

  35. Kato J, Kida O, Nakamura S, Sasaki A, Takiguchi K, Tanaka K. 1986. Dissociation between plasma and atrial content of atrial natriuretic peptide (ANP) following sodium load in rats. Life Sci 39:2623–2627.

    Article  PubMed  CAS  Google Scholar 

  36. Gradin K, Hedner J, Hedner T, Towle AC, Pettersson A, Persson B. 1987. Effects of chronic salt loading on plasma atrial natriuretic peptide (ANP) in the spontaneously hypertensive rat. Acta Physiol Scand 129:67–72.

    Article  PubMed  CAS  Google Scholar 

  37. Tanaka I, Inagami T. 1986. Increased concentration of plasma immunoreactive atrial natriuretic factor in Dahl salt sensitive rats with sodium chloride-induced hypertension. J Hyperten 4:109–112.

    Article  CAS  Google Scholar 

  38. Schwartz D, Katsube NC, Needleman P. 1986. Atriopeptins in fluid and electrolyte homeostasis. Fed Proc 45:2361–2365.

    PubMed  CAS  Google Scholar 

  39. Snajdar RM, Dene H, Rapp JP. 1987. Partial characterization of atrial natriuretic factor in the hearts of Dahl salt-sensitive and salt-resistant rats. Endocrinology 120:2512–2520.

    Article  PubMed  CAS  Google Scholar 

  40. Dietz JR. 1987. Control of atrial natriuretic factor release from a rat heart-lung preparation. Am J Physiol 252:R498–R502.

    PubMed  CAS  Google Scholar 

  41. Gibbs DM. 1987. Noncalcium-dependent modulation of in vitro atrial natriuretic factor release by extracellular osmolality. Endocrinology 120:194–197.

    Article  PubMed  CAS  Google Scholar 

  42. Peterson MB, Mead RJ, Welty JD. 1973. Free amino acids in congestive heart failure. J Molec Cell Cardiol 5:139–147.

    Article  CAS  Google Scholar 

  43. Koepke JP, DiBona GF. 1987. Blunted natriuresis to atrial natriuretic peptide in chronic sodium-retaining disorders. Am J Physiol 252:F865–F871.

    PubMed  CAS  Google Scholar 

  44. Saito Y, Nakao K, Morii N, Sugawara A, Shiono S, Yamada T, Itoh H, Sakamoto M, Kurahashi K, Fujiwara M, Imura H. 1986. Bay K 8644, a voltage-sensitive calcium channel agonist, facilitates secretion of atrial natriuretic polypeptide from isolated perfused rat hearts. Biochem Biophys Res Commun 138:1170–1176.

    Article  PubMed  CAS  Google Scholar 

  45. McBroom MJ, Welty JD. 1985. Effects of taurine and verapamil on heart calcium in hamsters and rats. Comp Biochem Physiol 82C:279–281.

    CAS  Google Scholar 

  46. Welty JD, McBroom MJ. 1985. Effects of verapamil and taurine administration on heart taurine and calcium in BIO 14.6 cardiomyopathic hamsters. Res Comm Chem Path Pharmacol 49:141–144.

    CAS  Google Scholar 

  47. Zicha J, Byšková E, Kuneš J, Pohlová I, Jelínek J. 1987. Sodium pump activity in young and adult salt hypertensive Dahl rats. Klin Wochenschr 65(Suppl VIII):76–81.

    PubMed  Google Scholar 

  48. Wald H, Epstein FH, Popovtzer MM. 1983. Effect of chronic salt loading on renal Na-K-ATPase activity in the rat. Proc Soc Exp Biol Med 172:291–296.

    PubMed  CAS  Google Scholar 

  49. Scherzer P, Wald H, Czaczkes JW. 1985. Na-K-ATPase in isolated rabbit tubules after unilateral nephrectomy and Na+ loading. Am J Physiol 248:F565–F573.

    PubMed  CAS  Google Scholar 

  50. Post RL, Merritt CR, Kinsolving CR, Albright CD. 1960. Membrane adenosine triphosphatase as a participant in the active transport of sodium and potassium in human erythrocyte. J Biol Chem 235:1796–1802.

    PubMed  CAS  Google Scholar 

  51. Khatter JC, Soni PL, Hoeschen RJ, Alto LE, Dhalla NS. 1981. Subcellular effects of taurine on guinea pig heart. In The effects of taurine on excitable tissues, Schaffer SW, Baskin SI, Kocsis JJ, eds. New York: Spectrum Publications, pp 281–294.

    Google Scholar 

  52. Welty JD, Welty MC. 1981. Effects of taurine on subcellular calcium dynamics in the normal and cardiomyopathic hamster heart. In The effects of taurine on excitable tissues, Schaffer SW, Baskin SI, Kocsis JJ, eds. New York: Spectrum Publications, pp 295–312.

    Google Scholar 

  53. Huxtable RJ, Sebring LA. 1986. Towards a unifying theory for the actions of taurine. Top Pharmacol Sci 7:481–485.

    Article  CAS  Google Scholar 

  54. Friedman SM, Friedman CL. 1976. Cell permeability, sodium transport, and the hypertensive process in the rat. Circ Res 39:433–441.

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Kluwer Academic Publishers, Boston/Dordrecht/London

About this chapter

Cite this chapter

McBroom, M.J., Rinaudo, M.S., Clough, D.L., Mueller, G.P., Haddy, F.J. (1989). Taurine and NaCl: Untoward Effects and a Possible Role for the Heart. In: Iwata, H., Lombardini, J.B., Segawa, T. (eds) Taurine and the Heart. Developments in Cardiovascular Medicine, vol 93. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1647-3_7

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1647-3_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8915-9

  • Online ISBN: 978-1-4613-1647-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics