Maedi-Visna. Etiology and Immune Response

  • G. Pétursson
Part of the Developments in Veterinary Virology book series (DVVI, volume 10)

Abstract

The causative agents of maedi, a slow progressive pneumonia and visna, a slow progressive demyelinating encephalitis of sheep are classified as lentiviruses, a subgroup of retroviruses. The lentivirus subgroup also includes caprine arthritis-encephalitis virus (CAEV), eguine infectious anemia virus and human immunodeficiency virus (HIV) which causes AIDS. These viruses are not oncogenic but cause cytolytic changes when replicating in permissive tissue culture cells. In the host they cause a persistent infection, characterized by a severe restriction of viral replication with a small number of cells infected, many of which carry the viral genetic information in the form of provirus DNA. In spite of a fairly good antibody response the host never gets rid of the virus, which results in a life-long infection.

Keywords

Formaldehyde Sucrose Phenol Pneumonia Influenza 

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References

  1. 1.
    Pálsson, P.A. In: Slow virus diseases of animals and man (Ed. R.H. Kimberlin), North Holland Publishing Co., Amsterdam, 1976, pp. 17–43.Google Scholar
  2. 2.
    Sigurðsson, B., Pálsson, P.A. and Tryggvadóttir, A. J. Infect. Dis. 93: 166–175, 1953.CrossRefGoogle Scholar
  3. 3.
    Sigurðardóttir, B. and Thormar, H. J. Infect. Dis. 114: 55–60, 1964.CrossRefGoogle Scholar
  4. 4.
    Guðnadóttir, M. and Pálsson, P.A. J. Infect. Dis. 115: 217–225, 1965.CrossRefGoogle Scholar
  5. 5.
    Sigurðsson, B. Brit. Vet. J. 110: 341–354, 1954.Google Scholar
  6. 6.
    Sigurðsson, B., Pálsson, P.A. and Grímsson, H. J. Neuropath. Exp. Neurol. 16: 389–403, 1957.CrossRefGoogle Scholar
  7. 7.
    Sigurðsson, B. and Pálsson, P.A. Brit. J. Exp. Path. 39: 519–528, 1958.Google Scholar
  8. 8.
    Sigurðsson, B., Thormar, H. and Pálsson, P.A. Arch. Ges. Virusforsch. 10: 368–381, 1960.CrossRefGoogle Scholar
  9. 9.
    Guónadóttir, M. and Pálsson, P.A. J. Infect. Dis. 117: 1–6, 1967.CrossRefGoogle Scholar
  10. 10.
    Thormar, H. Res. Vet. Sci. 6: 117–129, 1965.PubMedGoogle Scholar
  11. 11.
    Thormar, H. and Helgadóttir, H. Res. Vet. Sci. 6: 456–465, 1965.PubMedGoogle Scholar
  12. 12.
    De Boer, G.F. Res. Vet. Sci. 18: 15–25, 1975.PubMedGoogle Scholar
  13. 13.
    Weiss, R., Teich, N., Varmus, H. and Coffin, J. (eds). RNA Tumor Viruses, 2nd ed. Cold Spring Harbour Laboratory, New York, 1982.Google Scholar
  14. 14.
    Haase, A.T. Nature 322: 130–136, 1986.PubMedCrossRefGoogle Scholar
  15. 15.
    Bouillant, A.M.P. and Becker, S.A.W.E. J. Natl. Cancer Inst. 72: 1075–1184, 1984.PubMedGoogle Scholar
  16. 16.
    Thormar, H. Virology 14: 463–475, 1961.PubMedCrossRefGoogle Scholar
  17. 17.
    Coward, J.E., Harter, D.H. and Morgan, C. Virology, 40: 1030–1038, 1970.PubMedCrossRefGoogle Scholar
  18. 18.
    Dubois-Dalcq, M., Reese, T.S. and Narayan, D. Virology, 74: 520–530, 1976.PubMedCrossRefGoogle Scholar
  19. 19.
    Pautrat, G., de Micco, P. and Tamalet, J. C.R. Acad. Sci. (D), Paris, 283: 211–214, 1976.Google Scholar
  20. 20.
    Thormar, H. and Cruikshank . Virology 25: 145–148, 1965.PubMedCrossRefGoogle Scholar
  21. 21.
    Pautrat, G., Tamalet, J., Chippaux-Hyppolite, C. and Brahic, M. C.R. Acad. Sci. (D), Paris 273: 653–6455, 1971.Google Scholar
  22. 22.
    Coward, J.E., Harter, D.H., Hsu, K.C. and Morgan, C. Virology 50: 925–930, 1972.PubMedCrossRefGoogle Scholar
  23. 23.
    Haase, A.T. Curr. Top. Microbiol. Immunol. 72: 101–156, 1975.PubMedGoogle Scholar
  24. 24.
    Brahic, M., Tamalet, J. and Chippaux-Hyppolite, C. C.R. Acad. Sci. (D), Paris 272: 2115–2118, 1971.Google Scholar
  25. 25.
    Brahic, M., Tamalet, J., Filippi, P. and Delbecchi, L. Biochimie 55: 885–891, 1973.PubMedCrossRefGoogle Scholar
  26. 26.
    Harter, D.H., Schlom, J., Spigeleman, S. Biochim. Biophys. Acta 240: 435–441, 1971.Google Scholar
  27. 27.
    Lin, F.H. and Thormar, H. J. Virol. 7: 582–587, 1971.PubMedGoogle Scholar
  28. 28.
    Sonigo, P., Alizon, M., Staskus, K., Klatzmann, D., Cole, S., Danos, O., Retzel, E., Tiollais, P., Haase, A. and Wain-Hobson, S. Cell 42: 369–382, 1985.PubMedCrossRefGoogle Scholar
  29. 29.
    Gillespie, D., Takemoto, K., Robert, M. and Gallo, R.C. Science 179: 1328–1330, 1973.PubMedCrossRefGoogle Scholar
  30. 30.
    Vigne, R., Brahic, M., Filippi, P. and Tamalet, J. J. Virol. 21: 386–395, 1977.PubMedGoogle Scholar
  31. 31.
    Vigne, R., Filippi, P., Brahic, M. and Tamalet, J. J. Virol. 28: 543–550, 1978.PubMedGoogle Scholar
  32. 32.
    Mountcastle, W., Harter, D. and Choppin, P. Virology 47: 542–545, 1972.PubMedCrossRefGoogle Scholar
  33. 33.
    Haase, A.T. and Baringer, J.R. Virology 57: 238–250, 1974.PubMedCrossRefGoogle Scholar
  34. 34.
    Lin, F.H. J. Virol. 25: 207–214, 1978.PubMedGoogle Scholar
  35. 35.
    Scott, J.V., Stowring, L., Haase, A.T., Narayan, D. and Vigne, R. Cell 18: 321–327, 1979.PubMedCrossRefGoogle Scholar
  36. 36.
    Klein, J.R., Martin, J., Griffing, G., Nathanson, N., Gorham, J., Shen, D.T., Pétursson, G., Georgsson, G., Pálsson, P.A. and Lutley, R. Res. Vet. Sci. 38: 129–133, 1985.PubMedGoogle Scholar
  37. 37.
    Lin, F.H. and Thormar, H. J. Virol. 6: 702–704, 1970.PubMedGoogle Scholar
  38. 38.
    Schlom, J., Harter, D.H., Burny, A. and Spiegelman, S. Proc. Natl. Acad. Sci. USA 68: 182–186, 1971.PubMedCrossRefGoogle Scholar
  39. 39.
    Stone, L.B., Scolnick, E., Takemoto, K.K. and Aaronson, S.A. Nature 229: 257–258, 1971.PubMedCrossRefGoogle Scholar
  40. 40.
    Lin, F.H., Genovese, M. and Thormar, H. Prep. Biochem. 3: 525–539, 1973.PubMedCrossRefGoogle Scholar
  41. 41.
    August, M.J., Harter, D.H. and Compans, R.W. J. Virol. 22: 832–834, 1977.PubMedGoogle Scholar
  42. 42.
    Thormar, H. Virology 19: 273–278, 1963.PubMedCrossRefGoogle Scholar
  43. 43.
    Harter, D.H. and Choppin, P.W. Virology 31: 219–288, 1967.Google Scholar
  44. 44.
    Haase, A.T. and Varmus, H.E. Nature New. Biol. 245: 237–239, 1973.PubMedGoogle Scholar
  45. 45.
    Brahic, M., Filippi, P., Vigne, R. and Haase, A.T. J. Virol. 24: 74–81, 1977.PubMedGoogle Scholar
  46. 46.
    Haase, A.T., Traynor, B.L., Ventura, P.E. and Alling, D.W. Virology 70: 65–79, 1976.PubMedCrossRefGoogle Scholar
  47. 47.
    Harris, J.D., Scott, J.V., Traynor, B., Brahic, M., Stowring, L., Ventura, P., Haase, A.T. and Peluso, R. Virology 113: 573–583, 1981.PubMedCrossRefGoogle Scholar
  48. 48.
    Clements, J.E., Narayan, O., Griffin, D.E. and Johnson, R.T. Virology 93: 377–386, 1979.PubMedCrossRefGoogle Scholar
  49. 49.
    Haase, A.T., Stowring, L., Harris, J.D., Traynor, B., Ventura, P., Peluso, R. and Brahic, M. Virology 119: 399–410, 1982.PubMedCrossRefGoogle Scholar
  50. 50.
    Vigne, R., Filippi, P., Quérat, G., Jouanny, C. and Sauze, N. In: Slow viruses in sheep, goats and cattle. (Eds. J.M. Sharp and R. Hoff-Jørgensen). Commission of the European Communities, Luxembourg, 1985, pp. 27–44.Google Scholar
  51. 51.
    Thormar, H. Virology 26: 36–43, 1965.PubMedCrossRefGoogle Scholar
  52. 52.
    Vigne, R., Filippi, P., Quérat, G., Sauze, N., Vitu, C, Russo, P. and Delori, P. J. Virol. 42: 1046–1056, 1982.PubMedGoogle Scholar
  53. 53.
    Filippi, P., Vigne, R., Quérat, G., Jouanny, C. and Sauze, N. J. Virol. 42: 1057–1066, 1982.PubMedGoogle Scholar
  54. 54.
    Pétursson, G., Nathanson, N., Georgsson, G., Panitch, H. and Pálsson, P.A. Lab. Invest. 35: 402–412, 1976.PubMedGoogle Scholar
  55. 55.
    Narayan, O., Wolinsky, J.S., Clements, J.E., Strandberg, J.D., Griffin, D.E. and Cork, L.C. J. Gen. Virol. 59: 345–356, 1982.PubMedCrossRefGoogle Scholar
  56. 56.
    Thormar, H. and Sigurðardóttir, B. Acta Pathol. Microbiol. Scand. 55: 180–186, 1962.PubMedCrossRefGoogle Scholar
  57. 57.
    Harter, D.H., Hsu, K.C. and Rose, H.M. Proc. Soc. Exp. Biol. Med. 129: 295–300, 1968.PubMedGoogle Scholar
  58. 58.
    Macintyre, E.H., Wintersgill, C.J. and Thormar, H. Nature New Biol. 237: 111–113, 1972.PubMedGoogle Scholar
  59. 59.
    Takemoto, K.K. and Stone, L.B. J. Virol. 7: 770–775, 1971.PubMedGoogle Scholar
  60. 60.
    Law, L.W. and Takemoto, K.K. J. Natl. Cancer Inst. 50: 1076–1079, 1973.Google Scholar
  61. 61.
    Brown, H.R. and Thormar, H. Microbios. 13: 51–60, 1975.Google Scholar
  62. 62.
    Macintyre, E.H., Wintersgill, C.J. and Vatter, A.E. J. Cell. Sci. 13: 173–191, 1973.PubMedGoogle Scholar
  63. 63.
    Pétursson, G., Martin, J.R., Georgsson, G., Nathanson, N. and Pálsson, P.A. In: Aspects of Slow and Persistent Virus Infections (Ed. D.A.J. Tyrrell). New Perspectives in Clinical Microbiology. Vol. 2 (Series ed. W. Brumfit). Martinus Nijhoff Publ. The Haque/Boston/London, 1979, pp. 165–197.Google Scholar
  64. 64.
    Haase, A.T., Stowring, L., Narayan, O., Griffin, D. and Price, D. Science 195: 175–177, 1977.PubMedCrossRefGoogle Scholar
  65. 65.
    Georgsson, G., Martin, J.R., Pálsson, P.A., Nathanson, N., Benediktsdóttir, E. and Pétursson, G. Acta Neuropathol. (Berl.), 48: 39–43, 1979.CrossRefGoogle Scholar
  66. 66.
    Brahic, M., Stowring, L., Ventura, P. and Haase, A.T. Nature 292: 240–242, 1981.PubMedCrossRefGoogle Scholar
  67. 67.
    Nathanson, N., Panitch, H., Pálsson, P.A., Pétursson, G. and Georgsson, G. Lab. Invest. 35: 444–451, 1976.PubMedGoogle Scholar
  68. 68.
    Narayan, O., Griffin, D.E. and Silverstein, A.M. J. Infect. Dis. 135: 800–806, 1977.PubMedCrossRefGoogle Scholar
  69. 69.
    Narayan, O., Sheffer, D., Clements, J.E. and Tennekoon, G. J. Exp. Med. 162: 1954–1959, 1985.CrossRefGoogle Scholar
  70. 70.
    Guónadóttir, M. and Kristinsdóttir, K. J. Immunol. 98: 663–667, 1967.Google Scholar
  71. 71.
    Thormar, H. Acta Pathol. Microbiol. Scand. 75: 296–302, 1969.PubMedGoogle Scholar
  72. 72.
    De Boer, G.F. J. Immunol. 104: 414–422, 1970.PubMedGoogle Scholar
  73. 73.
    Terpstra, C. and De Boer, G.F. Arch. Ges. Virusforsch. 43: 53–62, 1973.PubMedCrossRefGoogle Scholar
  74. 74.
    Cutlip, R.C., Jackson, T.A. and Laird, G.A. Am. J. Vet. Res. 38: 1081–1084, 1977.PubMedGoogle Scholar
  75. 75.
    Karl, S.C. and Thormar, H. Infect. Immun. 4: 715–719, 1971.PubMedGoogle Scholar
  76. 76.
    Houwers, D.J., Gielkens, A.L.J, and Schaake jr., J. Vet. Microbiol. 7: 209–219, 1982.PubMedCrossRefGoogle Scholar
  77. 77.
    Thormar, H. J. Immunol. 90: 185–192, 1963.PubMedGoogle Scholar
  78. 78.
    Guónadóttir, M. and Pálsson, P.A. J. Immunol. 95: 1116–1120, 1965.Google Scholar
  79. 79.
    Lutley, R., Pétursson, G., Pálsson, P.A., Georgsson, G., Klein, J. and Nathanson, N. J. Gen. Virol. 64: 1433–1440, 1983.PubMedCrossRefGoogle Scholar
  80. 80.
    Pétursson, G., Douglas, B.M. and Lutley, R. In: Slow viruses in sheep, goats and cattle. (Eds. J.M. Sharp and R. Hoff-Jørgensen). Commission of the European Communities, Luxembourg, 1985, pp. 211–216.Google Scholar
  81. 81.
    Mehta, P.D. and Thormar, H. Infect. Immun. 10: 678–680, 1974.PubMedGoogle Scholar
  82. 82.
    Narayan, O., Strandberg, J.D., Griffin, D.E., Clements, J.E. and Adams, R.J. In: Viruses and demyelinating diseases. (Eds. C.A. Mims, M.L. Cuzner and R.E. Kelly). Academic Press, New York, London, 1983, pp. 125–140.Google Scholar
  83. 83.
    Houwers, D.J. and Schaake, J. In: Slow viruses of sheep, goats and cattle. (Eds. J.M. Sharp and R. Hoff-Jørgensen). Commission of the European Communities, Luxembourg, 1985, 149–151.Google Scholar
  84. 84.
    Stanley, J., Bhaduri, L.M., Narayan, O. and Clements, J.E. J. Virol. 61: 1019–1028, 1987.PubMedGoogle Scholar
  85. 85.
    Georgsson, G., Houwers, D.J., Stefánsson, K., Pálsson, P.A. and Pétursson, G. Acta Neuropathol. (Berl.) 73: 406–408, 1987.CrossRefGoogle Scholar
  86. 86.
    Thormar, H. and von Magnus, H. Acta Pathol. Microbiol. Scand. 57: 261–267, 1963.PubMedCrossRefGoogle Scholar
  87. 87.
    Thormar, H., Wisniewski, H.M. and Lin, F.H. Nature 279: 245–246, 1979.PubMedCrossRefGoogle Scholar
  88. 88.
    Griffin, D.E., Narayan, O., Bukowski, J.F., Adams, R.J. and Cohen, S.R. Ann. Neurol. 4: 212–218, 1978.PubMedCrossRefGoogle Scholar
  89. 89.
    Nathanson, N., Pétursson, G., Georgsson, G., Pálsson, P.A., Martin, J.R. and Miller, A. J. Neuropathol. Exp. Neurol. 38: 197–208, 1979.PubMedCrossRefGoogle Scholar
  90. 90.
    Martin, J.R., Goudswaard, J., Pálsson, P.A., Georgsson, G., Pétursson, G., Klein, J. and Nathanson, N. J. Neuroimmunol. 3: 139–148, 1982.PubMedCrossRefGoogle Scholar
  91. 91.
    Guðnadóttir, M. Progr. Med. Virol. 18: 336–349, 1974.Google Scholar
  92. 92.
    Narayan, O., Griffin, D.E. and Chase, J. Science 197: 376–378, 1977.PubMedCrossRefGoogle Scholar
  93. 93.
    Narayan, O., Griffin, D.E. and Clements, J.E. J. Gen. Virol. 41: 343–352, 1978.CrossRefGoogle Scholar
  94. 94.
    Narayan, O., Clements, J.E., Griffin, D.E. and Wolinsky, J.S. Infect. Immun. 32: 1045–1050, 1981.PubMedGoogle Scholar
  95. 95.
    Dubois-Dalcq, M., Narayan, O. and Griffin, D.E. Virology, 92: 353–366, 1979.PubMedCrossRefGoogle Scholar
  96. 96.
    Clements, J.E., Pedersen, F.S., Narayan, O. and Haseltine, W.A. Proc. Natl. Acad. Sci. U.S.A. 77: 4454–4458, 1980.PubMedCrossRefGoogle Scholar
  97. 97.
    Clements, J.E., D’Antonio, N. and Narayan, O. J. Molec. Biol. 158: 415–434, 1982.PubMedCrossRefGoogle Scholar
  98. 98.
    Thormar, H., Barshatzky, M.R., Arnesen, K. and Kozlowski, P.B. J. Gen. Virol. 64: 1427–1432, 1983.PubMedCrossRefGoogle Scholar
  99. 99.
    Pétursson, G., Nathanson, N., Pálsson, P.A., Martin, J.R. and Georgsson, G. Acta Neurol. Scand. (Suppl. 67), 57: 205–219, 1978.Google Scholar
  100. 100.
    Griffin, D., Narayan, O. and Adams, R.J. J. Inf. Dis. 138: 340–350, 1978.CrossRefGoogle Scholar
  101. 101.
    Sihvonen, L. Res. Vet. Sci. 30: 217–222, 1981.PubMedGoogle Scholar
  102. 102.
    Larsen, H.J., Hyllseth, B. and Krogsrud, J. Am. J. Vet. Res. 43: 379–383, 1982.PubMedGoogle Scholar
  103. 103.
    Larsen, H.J., Hyllseth, B. and Krogsrud, J. Am. J. Vet. Res. 43: 384–389, 1982.Google Scholar
  104. 104.
    Thormar, H. In: Slow virus diseases of animals and man. (Ed. R.H. Kimberlin). North-Holland Publ. Co., Amsterdam, 1976, pp. 97–114.Google Scholar
  105. 105.
    Trowbridge, R.S. Infect. Immun. 11: 862–868, 1975.PubMedGoogle Scholar
  106. 106.
    Carroll, D., Ventura, P., Haase, A., Rinaldo, jr., C.R., Overall, jr., J.C. and Glasgow, L.A. J. Infect. Dis. 138: 614–617, 1978.PubMedCrossRefGoogle Scholar
  107. 107.
    Pétursson, G. Proc. XVth Nordic Vet. Congress, Stockholm, 1986, pp. 273–276.Google Scholar
  108. 108.
    Cutlip, R.C., Lehmkuhl, H.D., Brogden, K.A. and Schmerr, M.J.F. Vet. Microbiol. 13: 201–204, 1987.PubMedCrossRefGoogle Scholar
  109. 109.
    Nathanson, N., Martin, J.R., Georgsson, G., Pálsson, P.A., Lutley, R.E. and Pétursson, G. J. Comp. Pathol. 91: 185–191, 1981.PubMedCrossRefGoogle Scholar
  110. 110.
    McGuire, T.C., Adams, S., Johnson, G.C., Klevjer-Anderson, P., Barbee, D.D. and Gorham, J.R. Am. J. Vet. Res. 47: 537–540, 1986.PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • G. Pétursson
    • 1
  1. 1.Institute for Experimental PathologyUniversity of IcelandReykjavíkIceland

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