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Indications for the Use of Intraspinal Opioids

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Spinal Narcotics

Part of the book series: Current Management of Pain ((CUMP,volume 6))

Abstract

Following identification of highly specific opioid receptors in the brain and spinal cord of animals and man in 1973 [1,2], it was demonstrated in 1976 that intrathecal morphine produced antinociception in rats [3]. The first clinical use of the technique for the treatment of cancer pain was reported in 1979 [4]. Today, ten years and several hundred international publications later, the technique of injecting opioids epidurally and intrathecally for the management of acute and chronic pain is well established. Although this modality is not the panacea early reports appeared to promise, its place as a major advance in the management of acute and chronic pain is beyond doubt. This chapter will attempt to provide the current indications for the use of epidural and intrathecal opioids.

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Authors
  1. Narinder Rawal
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Editors and Affiliations

  1. Department of Anesthesiology and Intensive Care, Orebro Medical Center Hospital, Orebro, Sweden

    Narinder Rawal M.D.,Ph.D. (Senior Consultant Anethetist, Visiting Professor) (Senior Consultant Anethetist, Visiting Professor)

  2. Department of Anesthesiology, University of Texas Medical School at Houston, Houston, TX, 77030, USA

    Narinder Rawal M.D.,Ph.D. (Senior Consultant Anethetist, Visiting Professor) (Senior Consultant Anethetist, Visiting Professor)

  3. Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Hanover, NH, 03756, USA

    Dennis W. Coombs M.D. (Assistant Professor of Anesthesiology) (Assistant Professor of Anesthesiology)

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© 1990 Kluwer Academic Publishers

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Rawal, N. (1990). Indications for the Use of Intraspinal Opioids. In: Rawal, N., Coombs, D.W. (eds) Spinal Narcotics. Current Management of Pain, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1609-1_3

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  • DOI: https://doi.org/10.1007/978-1-4613-1609-1_3

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