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The Action of Calcium Channel Agonists on the Mammalian Ventricular Myocardium

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Pathophysiology and Pharmacology of Heart Disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 102))

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Abstract

Dihydropyridine Ca channel agonists bear close structural resemblance to several Ca channel antagonists. The most extensively investigated agent in this group is BAY k 8644, first described by Schramm and coworkers. 1−4 Other Ca channel agonists are YC170,5 202–791,6 H 160–51.7 R202–7916 and CGP28–392.8,9 The characteristic property of these agents is to increase the ‘open time’ of the ‘L’ type of calcium channels resulting either in an increase in calcium current during an action potential or during depolarisation by other means.10 The cardiovascular consequence of this is an increase in cardiac contractility and vasoconstriction.2 It is this latter property which has precluded the clinical use of calcium channel agonists in heart failure. However, the calcium channel agonists hold an important place as pharmacological tools. This review will consider some of the anomalous actions of BAY k 8644 which result in “negative” inotropy under certain circumstances. A possible effect of these drugs on sarcoplasmic reticular function, in addition to their better known effect of enhancing trans-sarcolemmal calcium current, will be discussed.

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Authors and Affiliations

  1. Departments of Pharmacology & Therapeutics, Anaesthesia and Internal Medicine, University of Manitoba, Faculty of Medicine, 770 Bannatyne Avenue, Winnipeg, Manitoba, Canada, R3E 0W3

    D. Bose, L. V. Hryshko, J. K. Saha, R. A. Bouchard & T. Chau

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  1. D. Bose
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  2. L. V. Hryshko
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  3. J. K. Saha
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  4. R. A. Bouchard
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  5. T. Chau
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Editors and Affiliations

  1. Postgraduate Institute of Medical Education & Research, Chandigarh, India

    Inder S. Anand  & Purshotam L. Wahi  & 

  2. St. Boniface General Hospital Research Center, Winnipeg, Canada

    Naranjan S. Dhalla

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© 1989 Kluwer Academic Publishers

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Bose, D., Hryshko, L.V., Saha, J.K., Bouchard, R.A., Chau, T. (1989). The Action of Calcium Channel Agonists on the Mammalian Ventricular Myocardium. In: Anand, I.S., Wahi, P.L., Dhalla, N.S. (eds) Pathophysiology and Pharmacology of Heart Disease. Developments in Cardiovascular Medicine, vol 102. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1607-7_6

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  • DOI: https://doi.org/10.1007/978-1-4613-1607-7_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8889-3

  • Online ISBN: 978-1-4613-1607-7

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