Transient Changes in Cyclic AMP and in Protein Kinase and Phosphorylase Activity During the Cardiac Cycle in the Canine Myocardium and the Effect of Propranolol

  • E.-G. Krause
  • Sabine Bartel
  • Inge Beyerdorfer
  • W. Freier
  • K. Gerber
  • D. Obst
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 102)


The function of the heart as a pump depends on the co-ordination of electrical, mechanical and metabolic activities of its cells. The prime regulator of these activities seems to be the intracellular calcium concentration which is subject to neural and humoral control mechanisms involving, in many instances, cyclic AMP and cyclic GMP.


Cardiac Cycle Activity Ratio Glycogen Phosphorylase Heart Cycle Systolic Phase 
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  1. 1.
    Wier WG. Sciences 1980;207:1085–1087.CrossRefGoogle Scholar
  2. 2.
    Fossel ET, Morgan HE, Ingwall JS. Proc Natl Acad Sci USA 1980;77:3654–3658.PubMedCrossRefGoogle Scholar
  3. 3.
    Toyo-Oka T, Nagayama K, Umeda M, Eguchi K, Hosada S. Biochim Biophys Res Commun 1986;135:808–815.CrossRefGoogle Scholar
  4. 4.
    Thompson CT, Rubio R, Berne RM. Amer J Physiol 1980;238:H389–H398.PubMedGoogle Scholar
  5. 5.
    Wollenberger A, Babskii E, Krause E-G, Genz S, Blohm D, Bogdanowa E. Biochem Biophys Res Commun 1973;55:446–452.PubMedCrossRefGoogle Scholar
  6. 6.
    Krause E-G, Battel S, Freier W, Warbanow W, Gerber K, Ludecke J, Obst D. Biomed Biochim Acta 1986;45:S205–S210.PubMedGoogle Scholar
  7. 7a.
    Brooker G. Sciences 1973;182:933–934CrossRefGoogle Scholar
  8. 7b.
    Adv Cyclic Nucl Res 1975;5:435–452.Google Scholar
  9. 8.
    Wikman-Coffelt J, Sievert R, Coffelt RJ, Parmley WW. Biochem Biophys Res Commun. 1983; 111:450–455.PubMedCrossRefGoogle Scholar
  10. 9.
    Krause E-G, Hosenfelder W. Patentschrift WPA 61 B/219887 Amt Fur Erfindungswesen der DDR 1981.Google Scholar
  11. 10.
    Gilman A. Proc Natl Acad Sci USA 1970;67:305–312.PubMedCrossRefGoogle Scholar
  12. 11a.
    Harper JR, Brooker G. J Cyclic Nucl Res 1975; 1:207–2l8)Google Scholar
  13. 11b.
    ibid. 1975;5:435–452.Google Scholar
  14. 12.
    Battel S, Krause E-G, Wollenberger A. Biomed Biochim Acta 1985;44:1303–1313.Google Scholar
  15. 13.
    England PJ. Biochem J 1976;160:295–304.PubMedGoogle Scholar
  16. 14.
    Krause E-G, Battel S, Karczewskl P, Lindenau K-F. Adv Myocardiol 1982;4:521–530.Google Scholar
  17. 15.
    Hearse DJ. J Mol Cell Cardiol 1983;15:653–657.PubMedCrossRefGoogle Scholar
  18. 16.
    Drummond GI, Duncan L. J Biol Chem 1970;245:976–983.PubMedGoogle Scholar
  19. 17.
    Drummond RW, Sordahl LA. J Mol Cell Cardiol 1981; 13:323–330.PubMedCrossRefGoogle Scholar
  20. 18.
    Wollenberger A, Irmler R. Recent Adv Stud Cardiac Struct Metabol 1978;12:689–695.Google Scholar
  21. 19.
    Drummond GI, Duncan L, Hertzman E. J Biol Chem 1966;241:5899–5903.PubMedGoogle Scholar
  22. 20.
    Gootman PM, Cohen MI. In: Umbach W, Koepchen HP. (eds) Central-rhythmic and Regulation. Hippokrates, Stuttgart, 1974. pp. 195–209.Google Scholar
  23. 21.
    Korner PI. In: Berne RM, Sperelakis N, Geiger SR. (eds) Handbook of Physiology. Am Physiol Soc, Bethseda, 1979. pp. 691–739.Google Scholar
  24. 22.
    Potter JD, Piascik MT, Wisler PL, Robertson SP, Johnson CL Ann NY Acad Sci 1980;356:220–231.PubMedCrossRefGoogle Scholar
  25. 23.
    Kakiuchi S, Yamazaki R, Teshima Y. Biochim Biophys Res Commun 1971;42:968–974.CrossRefGoogle Scholar
  26. 24.
    Keely SL, Corbin JD, Park CR. J Biol Chem 1975;250:4832–4840.PubMedGoogle Scholar
  27. 25.
    Namm DH, Mayer SE, Maltbie M. Mol Pharmacol 1968;4:522–530.PubMedGoogle Scholar
  28. 26.
    Sayers ST, Barany K. FEBS letters 1983;154:305–310.PubMedCrossRefGoogle Scholar
  29. 27.
    McNeill JH, Daviles RS, LaRochelle D. Comp Biochem Physiol 1971;39B:689–693.Google Scholar
  30. 28.
    Denton RM, McCormack JG. Am J Physiol 1985;249:E543–E554.PubMedGoogle Scholar
  31. 29.
    Krause E-G, Beyerdorfer I. J Mol Cell Cardiol 1988;Suppl. (in press)Google Scholar
  32. 30.
    Wollenberger A, Will H. Life Sci 1978;22:1159–1178.PubMedCrossRefGoogle Scholar
  33. 31.
    Huggins JP, England PJ. In: Cohen P, Houslay MD (eds) Molecular mechanisms of transmembrane signalling. Elsevier, Amsterdam, 1985. pp. 57–87.Google Scholar
  34. 32.
    Krause E-G, Battel S, Beyerdorfer PI, Freier W, Gerber K, Holtzhauer M, Karczewski P, Lindeke A. J Mol Cell Cardiol 1988;Suppl. (in press)Google Scholar

Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • E.-G. Krause
    • 1
  • Sabine Bartel
    • 1
  • Inge Beyerdorfer
    • 1
  • W. Freier
    • 1
  • K. Gerber
    • 1
  • D. Obst
    • 1
  1. 1.Central Institute of Cardiovascular Research and Centre of Engineering Scientific InstrumentsAcademy of Sciences of the GDRBerlinGermany

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