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P-glycoprotein in breast cancer

  • Douglas E. Merkel
  • Suzanne A. W. Fuqua
  • William L. McGuire
Part of the Cancer Treatment and Research book series (CTAR, volume 48)

Abstract

Resistance to cytotoxic chemotherapy is a major impediment to the successful treatment of breast cancer. Adjuvant chemotherapy, though given under theoretically optimal conditions of low tumor bulk [1], often fails to eradicate micrometastasis. Once metastasis is grossly evident, most breast cancers have intrinsic resistance to single-agent chemotherapy. The response rate of such advanced disease to doxorubicin is less than 40%; the response rate to vinca alkyloids is only 21% [2,3]. Though higher initial response rates can be achieved with combination chemotherapy [4], essentially all breast cancers will become resistant to cytotoxic therapy. This might occur either through the outgrowth of resistant subclones under the selection pressure of chemotherapy [5], or through the induction of a resistant phenotype in surviving cancer cells. In either case, this resistance frequently includes a component of cross-resistance to unrelated agents, as second-line chemotherapy is marked by lower response rates and brief response durations [6].

Keywords

Breast Cancer Human Breast Cancer Cell Human Breast Cancer Cell Line Multiple Drug Resistance Breast Cancer Specimen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • Douglas E. Merkel
  • Suzanne A. W. Fuqua
  • William L. McGuire

There are no affiliations available

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