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Circumvention of drug resistance with calcium channel blockers and monoclonal antibodies

  • Chapter
Book cover Drug Resistance in Cancer Therapy

Part of the book series: Cancer Treatment and Research ((CTAR,volume 48))

Abstract

One of the major obstacles in current cancer chemotherapy is the development of drug resistance during treatment. Drug resistance in cancer patients is complex. Reasons for clinical resistance include metabolic inactivation and excretion of antitumor agents by the liver, kidney, and other organs. In addition, it has been found that tumor cells can acquire resistance to anticancer drugs. It is generally accepted that drug resistance at the cellular level (cellular resistance) is also an important mechanism of drug resistance in patients.

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  1. Takashi Tsuruo
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  1. Fox Chase Cancer Center, 7701 Burholme Auenue, Philadelphia, PA, 19111, USA

    Robert F. Ozols M.D., Ph.D.

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© 1989 Kluwer Academic Publishers

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Tsuruo, T. (1989). Circumvention of drug resistance with calcium channel blockers and monoclonal antibodies. In: Ozols, R.F. (eds) Drug Resistance in Cancer Therapy. Cancer Treatment and Research, vol 48. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1601-5_6

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  • DOI: https://doi.org/10.1007/978-1-4613-1601-5_6

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