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Anthracycline resistance

  • Chapter
Drug Resistance in Cancer Therapy

Part of the book series: Cancer Treatment and Research ((CTAR,volume 48))

Abstract

The antitumor properties of anthracyclines were discovered in 1963, when daunomycin was found to be cytotoxic to leukemic cells [1], Adriamycin, a closely related anthracycline, was discovered in 1969 and also showed potent antitumor activity [2,3]. Today, daunorubicin and doxorubicin are used extensively in cancer chemotherapy, although severe side effects and development of drug resistance continue to place limits on the effectiveness of these agents.

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Authors
  1. Alok Bhushan
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  2. John C. Kermode
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  3. James Posada
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  4. Thomas R. Tritton
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Editors and Affiliations

  1. Fox Chase Cancer Center, 7701 Burholme Auenue, Philadelphia, PA, 19111, USA

    Robert F. Ozols M.D., Ph.D.

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Bhushan, A., Kermode, J.C., Posada, J., Tritton, T.R. (1989). Anthracycline resistance. In: Ozols, R.F. (eds) Drug Resistance in Cancer Therapy. Cancer Treatment and Research, vol 48. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1601-5_5

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