Abstract
The use of aggressive, combined modality cancer treatment has made a positive impact in the management of several human malignancies. Unfortunately, despite this aggressive approach, many tumors are not controlled, and inevitable questions arise concerning the optimal use of combined modality therapy. A particularly difficult issue is that of determining the optimal timing sequence of each modality. For example, it is known that certain chemotherapy drugs can interact with radiation such that the radiation effects are enhanced. Depending upon the particular drugs used, the enhancement might be maximal if both the radiation and drugs were given simultaneously. Such an approach might be desirable if the effects were restricted to the tumor. Unfortunately, disastrous, unwanted normal tissue responses can result from such a combination. Indeed, an overwhelming number of permutations can be envisioned when combining multiple-agent chemotherapy and radiation therapy with respect to timing, notwithstanding the possible differences in response of tumor versus normal tissues to such combinations.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Minna, J.D., Higgins, G.A. and Glatstein, E.J. (1982). Cancer of the lung. In Principles and Practice of Oncology, eds. DeVita, V.T., Jr., Hellman, S., Rosenberg, S.A., Lippincott, Philadelphia, pp. 396–474.
Goldie, J.H. and Coldman, A.J. (1979). A mathematical model formulating the drug sensitivity of tumors to their spontaneous mutation rate. Cancer Treat. Rep. 63:1727–1733.
Coldman, A.J. and Goldie, J.H. (1982). A mathematical model of drug resistance in neoplasms. In Drug and Hormone Resistance in Neoplasia, eds. Bruchovsksy, N., Goldie, J.H., CRC Press, Boca Raton, FL., pp. 55–78.
Ling, V., Kartner, N., Sudo, T., Siminovitch, L. and Riordan, J.R. (1983). Multidrug-resistance phenotype in Chinese hamster ovary cells. Cancer Treat. Rep. 67:869–874.
Munro, T.R. (1970). The relative radiosensitivity of the nucleus and cytoplasm of the Chinese hamster fibroblasts. Radiat. Res. 42:451–470.
Russo, A., Mitchell, J.B., Kinsella, T., Morstyn, G. and Glatstein, E. (1985). Determinants of radiosensitivity. Semin. Oncol. 12:332–349.
Malaise, E.P., Fertil, B., Chavaudra, N. and Guichard, M. (1986). Distribution of radiation sensitivities for human tumor cells of specific histological types: Comparison of in vitro and in vivo data. Int. J. Radiat. Oncol. Biol. Phys. 12:617–624.
Russo, A., DeGraff, W., Friedman, N. and Mitchell, J.B. (1986). Selective modulation of glutathione levels in human normal versus tumor cells and subsequent differential response to chemotherapy drugs. Cancer Res. 46:2845–2848.
Belli, J.A. and Harris, J.R. (1979). Adriamycin resistance and radiation response. Int. J. Radiat. Oncol. Biol. Phys. 5:1231–1234.
Wallner, K. and Li, G.C. (1986). Adriamycin resistance, heat resistance, and radiation response in Chinese hamster fibroblasts. Int. J. Radiat. Oncol. Biol. Phys. 12:829–833.
Wallner, K.E. and Li, G.C. (1987). Effect of cisplatin resistance on cellular radiation response. Int. J. Radiat. Oncol. Biol. Phys. 13:587–591.
Louie, K.G., Behrens, B.C., Kinsella, T.J., Hamilton, T.C., Grotzinger, K.R., McKoy, W.M., Winker, M.A. and Ozols, R.F. (1985). Radiation survival parameters of antineoplastic drug-sensitive and -resistant human ovarian cancer cell lines and their modification by buthionine sulfoximine. Cancer Res. 45:2110–2115.
Hamilton, T.C., Young, R.C. and Ozols, R.F. (1984). Experimental model systems of ovarian cancer: Applications to the design and evaluation of new treatment approaches. Semin. Oncol. 11:285–298.
Hamilton, T.C., Winker, M.A., Louie, K.G., Batist, G., Behrens, B.E., Tsuruo, T., Grotzinger, K.R., McKoy, W.M., Young, R.C. and Ozols, R.F. (1985). Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug resistant and sensitive human ovarian cancer cell lines by buthionine sulfoximine mediated glutathione depletion. Biochem. Pharmacol. 34:2583–2586.
Mitchell, J.B. and Russo, A. (1987). The role of glutathione in radiation and drug-induced cytotoxicity. Br. J. Cancer [Suppl]. 55:96–104.
Russo, A. and Mitchell, J.B. (1984). Radiation response of Chinese hamster cells after elevation of intracellular glutathione levels. Int. J. Radiat. Oncol. Biol. Phys. 10:1243–1247.
Mitchell, J.B., Russo, A., Biaglow, J.E. and McPherson, S. (1983). Cellular glutathione depletion by diethyl maleate or buthionine sulfoximine: No effect of glutathione depletion on the oxygen enhancement ratio. Radiat. Res. 96:442–428.
Vos, O. and Roos-Verhey, W.S.D. (1988). Radioprotection by glutathione esters and cysteamine in normal and glutathione-depleted mammalian cells. Int. J. Radiat. Biol. 53:273–281.
Biaglow, J.E., Clark, E.P., Epp, E.R., Morse-Guadio, M., Varnes, M.E. and Mitchell, J.B., (1983). Nonprotein thiols and the radiation response of A549 human lung carcinoma cells. Int. J. Radiat. Biol. 44:489–495.
Mitchell, J.B., Gamson, J., Russo, A., Friedman, N., DeGraff, W., Carmichael, J. and Glatstein, E. (1988). Chinese hamster pleiotropic multidrug-resistant cells are not radioresistant. NCI Monogr. 6:187–197.
Mitchell, J.B., Russo, A., Cowan, K.H. and Glatstein, E. (1988). Radiosensitivity assessment of chemotherapy drug resistant human tumor cell lines. Proc. Am. Assoc. Cancer Res. 29:300.
Brock, W., Campbell, H., Goepfert, H. and Peters, L.J. (1987). Radiosensitivity testing of human tumor cell clutures—A potential method of predicting the response to radiotherapy. Cancer Bull. 39:98–102.
Baker, F.L., Spitzer, G., Ajani, J.A., Brock, W.A., Lukeman, J., Pathak, S., Tomasovic, B., Thielvoldt, D., Williams, M., Vines, C. and Tolfilon, P. (1986). Drug and radiation sensitivity measurements of successful primary monolayer culturing of human tumor cells using cell-adhesive matrix and supplemented medium. Cancer Res. 46:1263–1274.
Sinclair, W.K. (1964). X-ray-induced heritable damage (small-colony formation) in cultured mammalian cells. Radiat. Res. 21:584–611.
Courtenay, V.D. (1969). Radioresistant mutants of L5178Y cells. Radiat. Res. 38:186–203.
Weichselbaum, R.R., Dahlberg, W., Beckett, M., Karrison, T., Miller, D., Clark, J. and Ervin T.J. (1986). Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head-and neck-cancer patients. Proc. Natl. Acad. Sci. USA 83:2684–2688.
Thomlinson, R.H. and Gray, L.H. (1955). The histological structure of some human lung cancers and the possible implications for radiotherapy. Br. J. Cancer 9:539–549.
Powers, W.E. and Tolmach, L.J. (1963). A multicomponent x-ray survival curve for mouse lymphosarcoma cells irradiated in vivo. Nature 197:710–711.
Urtasun, R.C., Chapman, J.D., Raleigh, J.A., Franko, A.J. and Koch, C.J. (1986). Binding of 3H-misonidazole to solid human tumors as a measure of tumor hypoxia. Int. J. Radiat. Oncol. Biol. Phys. 12:1263–1267.
Hall, E.J. (1988). The oxygen effect and reoxygenation. In Radiobiology for the Radiologist, J.B. Lippincott Co., Philadelphia, pp. 137–160.
Barendsen, G.W., Koot C.J., Van Kersen, G.R., Bewley, D.K., Field, S.B. and Parnell, C.J. (1966). The effect of oxygen on impairment of the proliferative capacity of human cells in culture by ionizing radiations of different LET. Int. J. Radiat. Biol. 10:317–327.
Broerse, J.J., Barendsen, G.W. and Van Kersen, G.R. (1968). Survival of cultured human cells after irradiation with fast neutrons of different energies in hypoxic and oxygenated conditions. Int. J. Radiat. Biol. 13:559–572.
Adams, G.E., Flockhart, I.R., Smithen C.E., Stratford, I.J., Wardman, P. and Watts, M.E. (1976). Electron-affinic sensitization. VII. A correlation between structures, one—electron reduction potentials, and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers. Radiat. Res. 67:9–20.
West, C., Stratford, I.J., Barrass, N. and Smith, E. (1981). A comparison of adriamycin and mAMSA in vitro: Cell lethality and SCE studies. Br. J. Cancer 44:798–809.
Thistlethwaite, A.J., Leeper, D.B., Moylan, D.J. and Neriinger, R.E., (1985). pH distribution in human tumors. Int. J. Radiat. Oncol. Biol. Phys. 11:1647–1652.
Benet, L.Z. and Sheiner, L.B., (1985). Pharmacokinetics: The dynamics of drug absorption, distribution, and elimination. In The Pharmacological Basis of Therapeutics, eds., Gilman, A.G., Goodman, L.S., Rail, T.W. and Murad, F., Macmillan Publishing Co., New York, pp. 3–34.
Terasima, R. and Tolmach, L.J. (1963). X-ray sensitivity and DNA synthesis in synchronous populations of HeLa cells. Science 140:490–492.
Morstyn, G., Hsu, S.M., Kinsella, T., Gratzner, H., Russo, A. and Mitchell, J.B. (1983). Bromodeoxyuridine in tumors and chromosomes detected with a monoclonal antibody. J. Clin. Invest. 72:1844–1850.
Wilson, G.D., McNally, N.J., Dunphy, E., Karcher, H. and Pfragner, R. (1985). The labelling index of human and mouse tumors assessed by bromodeoxyuridine staining in vitro and in vivo and flow cytometry. Cytometry 6:641–647.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Kluwer Academic Publishers
About this chapter
Cite this chapter
Mitchell, J.B., Russo, A., Cook, J.A., Glatstein, E. (1989). Tumor cell drug and radiation resistance: Does an interrelationship exist?. In: Ozols, R.F. (eds) Drug Resistance in Cancer Therapy. Cancer Treatment and Research, vol 48. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1601-5_12
Download citation
DOI: https://doi.org/10.1007/978-1-4613-1601-5_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8886-2
Online ISBN: 978-1-4613-1601-5
eBook Packages: Springer Book Archive