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Transforming growth factors-α and -β and their potential roles in neoplastic transformation

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Oncogenes

Part of the book series: Cancer Treatment and Research ((CTAR,volume 47))

Abstract

Two types of growth factors have been termed transforming growth factors (TGFs) because they were discovered for their ability to elicit cellular transformation when added to an immortalized nonneoplastic cell line. One of these, TGF-α, is structurally related to epidermal growth factor (EGF) and competes for binding to the same receptor, while the other one, TGF-β, is a structurally unrelated protein with distinct receptors.

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  1. Rik Derynck
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Editors and Affiliations

  1. Cancer Research Institute, University of California, San Francisco, USA

    Christopher Benz

  2. Lineberger Cancer Research Center, The University of North Carolina at Chapel Hill, USA

    Edison Liu

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© 1989 Kluwer Academic Publishers

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Derynck, R. (1989). Transforming growth factors-α and -β and their potential roles in neoplastic transformation. In: Benz, C., Liu, E. (eds) Oncogenes. Cancer Treatment and Research, vol 47. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1599-5_8

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  • DOI: https://doi.org/10.1007/978-1-4613-1599-5_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8885-5

  • Online ISBN: 978-1-4613-1599-5

  • eBook Packages: Springer Book Archive

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