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The platelet-derived growth factor system

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Oncogenes

Part of the book series: Cancer Treatment and Research ((CTAR,volume 47))

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Abstract

Platelet-derived growth factor (PDGF) is a potent mitogen for mesenchymal cells in culture. PDGF was first recognized as a regulator of mesenchymal cell proliferation in the setting of vascular injury and wound healing [1,2]. It has become clear, however, that PDGF and its receptors (the PDGF system) play equally important roles in normal developmental and pathological processes, as well as in the genesis of certain neoplasms. In this respect, the PDGF system is appropriately considered within the broader context of human oncogenes.

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Authors
  1. Shaun R. Coughlin
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  2. Mark T. Keating
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Editor information

Editors and Affiliations

  1. Cancer Research Institute, University of California, San Francisco, USA

    Christopher Benz

  2. Lineberger Cancer Research Center, The University of North Carolina at Chapel Hill, USA

    Edison Liu

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© 1989 Kluwer Academic Publishers

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Coughlin, S.R., Keating, M.T. (1989). The platelet-derived growth factor system. In: Benz, C., Liu, E. (eds) Oncogenes. Cancer Treatment and Research, vol 47. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1599-5_7

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  • DOI: https://doi.org/10.1007/978-1-4613-1599-5_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8885-5

  • Online ISBN: 978-1-4613-1599-5

  • eBook Packages: Springer Book Archive

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