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Percutaneous Transluminal Coronary Angioplasty in Acute Myocardial Infarction

  • Chapter
Early Interventions in Acute Myocardial Infarction

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 97))

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Abstract

During the last five years, there has been a striking change in the early management of acute myocardial infarction. This results from several hemodynamic investigations that clearly established that thrombosis [1–2] plays a major role in this disease. Both early and late mortality of patients after myocardial infarction is mainly related to the degree of dysfunction of the left ventricle, which in turn depends on the size of the initial infarct. Therefore, it has been attempted to obtain immediate reperfusion of the infarction myocardium. Immediate thrombolytic therapy is a rational mean of achieving early reperfusion. Several thrombolytic agents are now available and can be administered by either the intracoronary or intravenous routes. However, after successful thrombolysis residual high-grade obstruction often persists at the site of the previous occlusion and could be responsible for continued myocardial ischemia and/or reocclusion. Therefore, percutaneous transluminal coronary angioplasty (PTCA) was proposed after successful thrombolysis. Later on, the ability to perform this technique in patients with acute myocardial infarction led several investigators to try percutaneous transluminal coronary angioplasty as the primary approach to reperfusion of the myocardium. Thus, we will address the problem of PTCA preceded by thrombolysis and primary PTCA in patients with acute myocardial infarction.

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Authors
  1. Michel E. Bertrand
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  2. Jean M. Lablanche
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  3. Jean L. Fourrier
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  4. A. Gommeaux
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Editors and Affiliations

  1. School of Medicine, University of California, San Francisco, USA

    Elliot Rapaport M.D.

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© 1989 Kluwer Academic Publishers

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Bertrand, M.E., Lablanche, J.M., Fourrier, J.L., Gommeaux, A. (1989). Percutaneous Transluminal Coronary Angioplasty in Acute Myocardial Infarction. In: Rapaport, E. (eds) Early Interventions in Acute Myocardial Infarction. Developments in Cardiovascular Medicine, vol 97. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1597-1_4

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  • DOI: https://doi.org/10.1007/978-1-4613-1597-1_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8884-8

  • Online ISBN: 978-1-4613-1597-1

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