Abstract
Chromosomal analysis of human hemopoietic malignancies has resulted in a better understanding of their etiology, improved their classification, allowed a better prediction of prognosis, and proved useful for the detection of malignant cells present in low frequency in the bone marrow samples. An example of the usefulness of chromosomal analysis in the myeloid leukemias is the identification of the Philadelphia chromosome in Chronic Granulocytic Leukemia and of a new protein encoded by the abl bcr genes as a consequence of the translocation of the abl proto-oncogene to chromosome 22 adjacent to the bcr gene [1]. It is not difficult to extrapolate that these observations will lead to an understanding of the basis for the initiation and maintenance of the malignancy. Other examples in which specific nonran-dom chromosomal abnormalities have been identified include t(15;17) in acute promyelocytic leukemia and the inversion of chromosome 16 in the M4Eo subtype of ANLL [1].
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© 1989 Kluwer Academic Publishers, Boston
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Campbell, L., Brown, J., Garson, O.M., Morstyn, G. (1989). Cytogenetic Abnormalities in Lung Cancer. In: Hansen, H.H. (eds) Basic and Clinical Concepts of Lung Cancer. Cancer Treatment and Research, vol 45. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1593-3_8
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DOI: https://doi.org/10.1007/978-1-4613-1593-3_8
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