High-dose Chemotherapy of Small-Cell Lung Cancer With and Without Bone Marrow Transplantation

  • J. P. Sculier
  • J. Klastersky
Part of the Cancer Treatment and Research book series (CTAR, volume 45)

Abstract

The administration of active combination chemotherapy has resulted in a major advance in the treatment of small-cell lung cancer (SCLC) [1,2]. Chemotherapy not only induces frequent objective response rates between 75% and 95%, but also prolongs survival significantly. However, only a minority of the patients cna be considered as cured [3–5]. The five-year overall survival rate is about 5–10% and there are 10 times more long-term survivors among patients with limited disease than in those with disseminated cancer. Various attempts have been proposed to improve these results [6]: administration of new active drugs, development of consolidation and/or maintenance treatments, use of more intensive regimens, administration of alternating or sequential combinations of chemotherapy, adjuvant thoracic irradiation and/or surgery, and/or more effective prevention of central nervous system relapses. Among these approaches, intensive chemotherapy is particularly appealing, although it may result in higher toxicity.

Keywords

Toxicity Oncol Doxorubicin Methotrexate Cyclophosphamide 

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Copyright information

© Kluwer Academic Publishers, Boston 1989

Authors and Affiliations

  • J. P. Sculier
  • J. Klastersky

There are no affiliations available

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