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Nutritional Treatment of Chronic Renal Failure pp 41–49Cite as

Abnormalities of Amino Acid Metabolism

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Part of the book series: Topics in Renal Medicine ((TIRM,volume 7))

Abstract

Restriction of protein (PR) intake for patients with chronic renal failure (CRF) aims at reducing retention of waste metabolites and, at the same time, at preserving lean body mass [1]. An additional target is to slow down the progression of renal failure [1], although this possibility is not yet definitely proven in humans. Nutritional treatment of CRF patients has advanced remarkably over the last few years, although many aspects of nitrogen (N) metabolism in CRF are still obscure.

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References

  1. Mitch WE, Walser M: (1986) Nutritional therapy of the uremic patient. In: Brenner BM, Rector FC (eds) The Kidney. Philadelphia: WB Saunders, pp 1759–1790.

    Google Scholar 

  2. Waterlow JC: (1984) Protein turnover with special reference to man. QJ Exp Physiol 69:409–438.

    CAS  Google Scholar 

  3. Kopple JD: (1983) Amino acid metabolism in chronic renal failure. In: Blackburn GL, Grant JP, Young VR, Wright J (eds) Amino Acid Metabolism and Medical Applications. Boston: PSG, pp 451–471.

    Google Scholar 

  4. Tizianello A, Deferrari G, Garibotto G, Robaudo C, Canepa A, Passerone GC: (1985) Is amino acid imbalance harmful to patients in chronic renal failure? Kidney Int 28 (Suppl 17): S79-S83.

    Google Scholar 

  5. Tizianello A, Deferrari G, Garibotto G, Robaudo C, Saffioti S, Paoletti E: (1988) Abnormalities of amino acids and ketoacid metabolism in chronic renal failure. Proceedings Xth International Congress of Nephrology. London: Bailliere Tindall, pp 1011–1025.

    Google Scholar 

  6. Betts PR, Green A: (1977) Plasma and urine amino acid concentrations in children with chronic renal insufficiency. Nephron 18:132–139.

    Article  PubMed  CAS  Google Scholar 

  7. Wilcken DEL, Gupta VJ: (1979) Sulphur containing amino acids in chronic renal failure with particular reference to homocystine and cysteine-homocysteine mixed disulphide. Eur J Clin Invest 9:301–307.

    Article  PubMed  CAS  Google Scholar 

  8. Tizianello A, Deferrari G, Garibotto G, Robaudo C: (1980) Amino acid metabolism and the liver in renal failure. Am J Clin Nutr 33:1354–1362.

    PubMed  CAS  Google Scholar 

  9. Tizianello A, Deferrari G, Garibotto G, Robaudo C, Lutman M, Passerone G, Bruzzone M: (1983) Branched-chain amino acid metabolism in chronic renal failure. Kidney Int 24 (Suppl 16):S17-S22.

    Google Scholar 

  10. Deferrari G, Garibotto G, Robaudo C, Lutman M, Viviani G, Sala R, Tizianello A: (1983) Glucose interorgan exchange in chronic renal failure. Kidney Int 24 (Suppl 16):S115-S120.

    Google Scholar 

  11. Tizianello A, Deferrari G, Garibotto G, Robaudo C, Saffioti S, Gurreri G, Paoletti E: (1987) Abnormalities in amino acid metabolism in patients with chronic renal failure. A pathophysiological approach to the nutritional treatment. I studies in the postabsorptive state. Contr Nephrol 55:1–10.

    CAS  Google Scholar 

  12. Deferrari G, Garibotto G, Robaudo C, Canepa A, Passerone GC, Tizianello A:(1984) Brain metabolism in uremia. In: Kleinberger, Ferenci, Riederer, Thaler (eds) Advances in hepatic encephalopathy and urea cycle diseases. Basel: Karger, pp 484–498.

    Google Scholar 

  13. McGale EHF, Pickford JD, Aber GM: (1972) Quantitative changes in plasma amino acids in patients with renal disease. Clin Chim Acta 38:395–403.

    Article  PubMed  CAS  Google Scholar 

  14. Young GA, Keogh JB, Parsons FM: (1975) Plasma amino acids and protein levels in chronic renal failure and changes caused by oral supplements of essential amino acids. Clin Chim Acta 61:205–213.

    Article  PubMed  CAS  Google Scholar 

  15. Sherwin RS, Basti C, Finklstein FO, Fisher M, Black H, Hendler R, Felig P: (1976) Influence of uremia and hemodialysis on the turnover and metabolic effects of glucagon. J Clin Invest 57:722–731.

    Article  PubMed  CAS  Google Scholar 

  16. Delaporte C, Jean G, Broyer M: (1978) Free plasma and muscle amino acids in uremic children. Am J Clin Nutr 31:1647–1651.

    PubMed  CAS  Google Scholar 

  17. Pye IF, McGale EHF, Stonier C, Hutchinson EC, Aber GM: (1979) Studies of cerebrospinal fluid and plasma amino acids in patients with steady-state chronic renal failure. Clin Chim Acta 92:65–72.

    Article  PubMed  CAS  Google Scholar 

  18. Alvestrand A, Furst P, Bergstrom J: (1982) Plasma and muscle amino acids in uremia: Influence of nutrition with amino acids. Clin Nephrol 18:297–305.

    PubMed  CAS  Google Scholar 

  19. Kopple JD, Swendseid ME: (1975) Evidence that histidine is an essential amino acid in normal and chronically uremic man. J Clin Invest 55:881–893.

    Article  PubMed  CAS  Google Scholar 

  20. Bergstrom J, Furst P, Noree LO, Vinnars E: (1978) Intracellular free amino acids in muscle tissue of patients with chronic uremia: Effect of peritoneal dialysis and infusion of essential amino acids. Clin Sci Mol Med 54:51–60.

    PubMed  CAS  Google Scholar 

  21. Felig P: (1975) Amino acid metabolism in man. Ann Rev Biochem 44:933–955.

    Article  PubMed  CAS  Google Scholar 

  22. Deferrari G, Garibotto G, Robaudo C, Canepa A, Bagnasco S, Tizianello A: (1985) Leg metabolism of amino acids and ammonia in patients with chronic renal failure. Clin Sci 69:143–151.

    PubMed  CAS  Google Scholar 

  23. Tizianello A, Deferrari G, Garibotto G, Gurreri G, Robaudo C: (1980) Renal metabolism of amino acids and ammonia in subjects with normal renal function and in patients with chronic renal insufficiency. J Clin Invest 65:1162–1173.

    Article  PubMed  CAS  Google Scholar 

  24. Deferrari G, Garibotto G, Robaudo C, Ghiggeri GM, Tizianello A: (1981) Brain metabolism of amino acids and ammonia in patients with chronic renal insufficiency. Kidney Int 20:505–510.

    Article  PubMed  CAS  Google Scholar 

  25. Pardridge WM, Oldendorf WH: (1977) Transport of metabolic substrates through the blood-brain barrier. J Neurochem 5:28–35.

    Google Scholar 

  26. Oldendorf WH, Szabo J: (1976) Amino acid assignment to one of three blood-brain barrier amino acid carriers. Am J Physiol 230:94–98.

    PubMed  CAS  Google Scholar 

  27. Wahren J, Felig P, Hagenfeldt L: (1976) Effect of protein ingestion on splanchnic and leg metabolism in normal man and in patients with diabetes mellitus. J Clin Invest 57:987–999.

    Article  PubMed  CAS  Google Scholar 

  28. Elia M, Livesey G: (1983) Effects of ingested steak and infused leucine on forelimb metabolism in man and the fate of the carbon skeletons and amino groups of branched-chain amino acids. Clin Sci 64:517–526.

    PubMed  CAS  Google Scholar 

  29. Deferrari G, Garibotto G, Robaudo C, Sala MR, Tizianello A: (1988) Splanchnic exchange of amino acids after amino acid ingestion in patients with chronic renal insufficiency. Am J Clin Nutr 48:72–83.

    PubMed  CAS  Google Scholar 

  30. Tizianello A, Deferrari G, Garibotto G, Robaudo C, Saffioti S, Salvidio G, Paoletti E: (1987). Abnormal amino acid metabolism after amino acid ingestion in chronic renal failure. Kidney Int 32 (Suppl 22):181–185.

    Google Scholar 

  31. Morgan HE, Jefferson LS, Wolpert EB, et al.: (1971) Regulation of protein synthesis in heart muscle. IL Effect of amino acid levels and insulin on ribosomal aggregation. J Biol Chem 246:2152–2162.

    PubMed  CAS  Google Scholar 

  32. Austin SA, Clemens MJ: (1981) The regulation of protein synthesis in mammalian cells by amino acid supply. Biosci Reports 1:35–47.

    Article  CAS  Google Scholar 

  33. Tizianello A, Deferrari G, Garibotto G, Robaudo C, Lutman M: (1981) Influence of arterial branched-chain amino acid concentration on cerebral uptake of branched-chain amino acids and glycine in chronic renal insufficiency. In Walser M, Williamson JR (eds) Metabolism and Clinical Implications of Branched-Chain Amino and Ketoacids. New York: Elsevier North Holland, pp 581–586.

    Google Scholar 

  34. Garibotto G, Lutman M, Canepa A, Robaudo C, Deferrari G, Tizianello A: (1983) Evidenza di una intolleranza agli aminoacidi nonessenziali nell’insufficienza renale cronica. Nefrologia. Dialisi, Trapianto 3:329–332.

    Google Scholar 

  35. Garibotto G, Deferrari G, Robaudo C, Saffioti S, Salvidio G, Paoletti E, Tizianello A: (1987) Effect of amino acid ingestion on blood amino acid profile in patients with chronic renal failure. Am J Clin Nutr 46:949–954.

    PubMed  CAS  Google Scholar 

  36. Deferrari G, Garibotto G, Robaudo C, Saffioti S, Paoletti E, Passerone GC, Tizianello A: (1987) Abnormalities in amino acid metabolism in patients with chronic renal failure. A pathophysiological approach to the nutritional treatment. II. Studies after amino acid ingestion. Contr Nephrol 55:11–19.

    CAS  Google Scholar 

  37. Neuberger A: (1981) Pathways of glycine metabolism. In: Waterlow JC, Stephen JML (eds) Nitrogen Metabolism in Man. London: Applied Science Publ, pp 253–261.

    Google Scholar 

  38. De Fronzo RA, Smith D, Alvestrand A: (1978) Insulin action in uremia. Kidney Int 24 (Suppl 16):S102-S114.

    Google Scholar 

  39. Rubenfeld S, Garber AJ: (1978) Abnormal carbohydrate metabolism in chronic renal failure. J Clin Invest 62:20–28.

    Article  PubMed  CAS  Google Scholar 

  40. Gejyo F, Ito G, Kinoshita Y: (1981) Identification of N-monoacetylcystine in uraemic plasma. Clin Sci 60:331–334.

    PubMed  CAS  Google Scholar 

  41. Alvestrand A, Furst P, Bergstrom J: (1983) Intracellular amino acids in uremia. Kidney Int 24 (Suppl 16):S9-S16.

    Google Scholar 

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Authors
  1. A. Tizianello
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  2. G. De Ferrari
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Editor information

Editors and Affiliations

  1. Clinica Medica I°, University of Pisa, 56100, Pisa, Italy

    Sergio Giovannetti

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© 1989 Kluwer Academic Publishers, Boston

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Tizianello, A., De Ferrari, G. (1989). Abnormalities of Amino Acid Metabolism. In: Giovannetti, S. (eds) Nutritional Treatment of Chronic Renal Failure. Topics in Renal Medicine, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1583-4_7

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  • DOI: https://doi.org/10.1007/978-1-4613-1583-4_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8877-0

  • Online ISBN: 978-1-4613-1583-4

  • eBook Packages: Springer Book Archive

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