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Hormonal Derangements in Chronic Renal Failure

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Part of the book series: Topics in Renal Medicine ((TIRM,volume 7))

Abstract

Chronic renal failure (CRF) is associated with a polyendocrinopathy [1–8] (figure 13–1) that is responsible for symptoms and complications. Endocrine abnormalities are due to intoxication (not corrected by treatments), nutritional deficiences, abnormalities in electrolyte and mineral metabolism, and abnormal endocrine and metabolic functions of the renal parenchyma.

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References

  1. Massry SG, Goldstein DA: (1978) Role of parathyroid hormone in uremic toxicity. Kidney Int 13:S39-S42.

    Google Scholar 

  2. Davis FB, Spector DA, Davis PJ, Hirsch BR, Walshe JJ, Yoshida K: (1982) Comparison of pituitary-thyroid function in patients with end stage renal disease and in age and sex matched controls. Kidney Int 21:362–364.

    Article  PubMed  CAS  Google Scholar 

  3. Czekalski S, Malczewsker B, Sobieszczyk S, Kozak W, Eder M, Gryczynska M, Baczyk K, Kosovicz J: (1981) Comparison of some circulating pituitary, thyroid, and gonadal hormone levels in nondialyzed and dialyzed males with chronic renal failure. Dial Transplant 10: 438–443.

    Google Scholar 

  4. Ramirez G, Gomez-Sanchez C, Meikle VA, Jubiz W: (1982) Evaluation of the hypothalamic hypophyseal adrenal axis in patients receiving long-term hemodialysis. Arch Intern Med 142:1448–1452.

    Article  PubMed  CAS  Google Scholar 

  5. Mooradian AD, Morley JE: (1984) Endocrine dysfunction in chronic renal failure. Arch Intern Med 144:351–353.

    Article  PubMed  CAS  Google Scholar 

  6. Gold CH, Morley JE, Viljoen M, Outim L, De Fomseca M, Kalk VJ: (1980) Gastric acid secretion and serum gastrin levels in patients with chronic renal failure on regular hemodialysis. Nephron 25:92–94.

    Article  PubMed  CAS  Google Scholar 

  7. Grzeszczak W, Kokot F, Dulawa J: (1987) Effects of naloxone administration on endocrine abnormalities in chronic renal failure. Am J Nephrol 7:93–100.

    Article  PubMed  CAS  Google Scholar 

  8. Zoccali C, Ciccarelli M, Mallamaci F, Maggiore Q: (1986) Enkephalins in plasma of patients with chronic renal failure. XXIIIrd EDTA-ERA Congress Budapest June 29-July 3 1986, Abstract Book, p 74.

    Google Scholar 

  9. Maack SG, Johnson V, Kau ST, Figuereido J, Sigulim MD: (1979) Renal filtration, transport, and metabolism of low-molecular-weight proteins: A review. Kidney Int 16:251–270.

    Article  PubMed  CAS  Google Scholar 

  10. Kaptein EM, Feinstein EI, Massry SG: (1982) Thyroid hormone metabolism in renal disease. Contr Nephrol 33:122–135.

    CAS  Google Scholar 

  11. Ardaillou R, Paillard F: (1980) Metabolism of polyptide hormones by the kidney. In: Hamburger J, Crosnier J, Grunfeld JP, Maxwell MH (eds) Advantage in Nephrology, Vol 9. Chicago: Year Book Medical Publishers, pp 247–269.

    Google Scholar 

  12. Druecke T, Lacour B: (1985) Parathyroid hormone and hyperlipemia of uremia. Contr Nephrol 49:12–19.

    Google Scholar 

  13. Lee JC, Parthermone JG, Deftos LJ: (1977) Immunochemical heterogeneity of calcitonin in renal failure. J Clin Endocrinol Metab 45:528–533.

    Article  PubMed  CAS  Google Scholar 

  14. Lauritzen JB, Lauritzen KB, Olsen ME, Timmerman L: (1982) Gastric inhibitory polypeptide (GIP) and insulin release in response to oral and intravenous glucose in uremic patients. Metabolism 9:1096–1099.

    Article  Google Scholar 

  15. Predel HG, Baecker A, Kipnowski J. Duesing R, Kramer HJ: Human atrial natriuretic peptide (hANP) in patients with progressive chronic renal failure (CRF). Xth International Congress of Nephrology, London 26–31 July 1987, Abstract Book.

    Google Scholar 

  16. Lim VS, Kathpalia SC, Frohman LA: (1979) Hyperprolactinemia and impaired pituitary response to suppression and stimulation in chronic renal failure: Reversal after transpantation. J Clin Endocrinol Metab 101–107.

    Google Scholar 

  17. Yoshiyama N, Nakajawa S, Takeuchi J, Okamoto R: (1981) Uremic galactorrhea: An endocrine profile. Nephron 28:227–233.

    Article  Google Scholar 

  18. Cowden EA, Ratcliffe WA, Ratcliffe JG, Kennedy AC: (1981) Hypothalamic-pituitary function in uremia. Acta Endocrinol 98:488–495.

    PubMed  CAS  Google Scholar 

  19. Distiller LA, Morley JE, Sagel J, Pokroy M, Rabkin R: (1975) Pituitary-gonadal function in chronic renal failure: The effect of luteinizing hormone-releasing hormone and the influence of dialysis. Metabolism 24:711–720.

    Article  PubMed  CAS  Google Scholar 

  20. Blackman MR, Weintraub BD, Kourides IA, Olamo JT, Santner TS, Rosen SW: (1981) Discordant elevation of the common alpha-subunit of the glycoprotein hormones compared to beta-subunits in serum of uremic patients. J Clin Endocrinol Metab 53:39–48.

    Article  PubMed  CAS  Google Scholar 

  21. Emmanouel DS, Jaspan JB, Rubenstein AH, Huen HJ, Fink E, Katz AI: (1978) Glucagon metabolism in the rat. Contribution of the kidney to the metabolic clearance rate of the hormone. J Clin Invest 62:6–13.

    Article  PubMed  CAS  Google Scholar 

  22. Lefebvre PJ, Luickx AS: (1975) Effect of acute kidney exclusion by ligation of renal arteries on peripheral plasma glucagon levels and pancreatic glucagon production in the anesthesized dog. Metabolism 24:1169–1176.

    Article  PubMed  CAS  Google Scholar 

  23. Sherwin RS, Basti C, Finkelstein FO, Black H, Hendler R, Feilig P: (1976) Influence of uremia and hemodialysis on the turnover and metabolic effects of glucagon. J Clin Invest 57:722–731.

    Article  PubMed  CAS  Google Scholar 

  24. Smith R, Grossman A, Gaillard R, Clement-Jones V, Batter S, Mallison J, Lowry PJ, Besser GM, Rees LH: (1981) Studies on circulating met-enkephalin and beta-endorphin: Normal subjects and patients with renal and adrenal disease. Clin Endocrinol 15:291–300.

    Article  CAS  Google Scholar 

  25. Elias AN, Vasiri ND, Maksy M: (1986) Plasma beta-endorphin and beta-lipotropin in patients with end-stage renal disease—Effects of hemodialysis. Nephron 43:173–176.

    Article  PubMed  CAS  Google Scholar 

  26. Aronin N, Krieger DT: (1983) Plasma immunoreactive beta-endorphin is elevated in uraemia. Clin Endocrinol 18:459–464.

    Article  CAS  Google Scholar 

  27. Arnaud CD: (1973) Hyperparathyroidism and renal failure. Kidney Int 4:89–95.

    Article  PubMed  CAS  Google Scholar 

  28. Chertow BS, Baylink DJ, Wergedal JF, Su MHH, Norman AW: (1975) Decrease in serum immunoreactive parathyroid hormone in rats and in parathyroid hormone secretion in vitro by 1,25-dihydroxycholecalciferol. J Clin Invest 56:668–678.

    Article  PubMed  CAS  Google Scholar 

  29. Madsen S, Olgaard K, Ladefoged J: (1981) Suppressive effect of 1,25-dihydroxyvitamin D3 on circulating parathyroid hormone in renal failure. J Clin Endocrinol Metab 53:823–827.

    Article  PubMed  CAS  Google Scholar 

  30. Cogan MG, Covey CM, Arieff AI, Wisnewski A, Clark OH, Lazarowit V, Leach W: (1978) Central nervous system manifestations of hyperparathyroidism. Am J Med 65:963–970.

    Article  PubMed  CAS  Google Scholar 

  31. Massry SG: (1985) Current status of the role of parathyroid hormone in uremic toxicity. Contr Nephrol 49:1–11.

    CAS  Google Scholar 

  32. Lacour B, Roullet JB, Druecker T: (1983) Les perturbationes du métabolisme lipidique dans l’insuffisance renale chronique. Nephrologie 4:75–83.

    PubMed  CAS  Google Scholar 

  33. Druecke T, Fleury I, Toure Y, De Vernejoul P, Fauchet M, Lesourd P, Le Pailleur C, Crosnier J: (1980) Effect of parathyroidectomy on left ventricular function in hemodialysis patients. Lancet 1:112–116.

    Article  Google Scholar 

  34. Meytes D, Bogin E, Ma A, Dukes PP, Massry SG: (1981) Effect of parathyroid hormone on erythropoiesis. J Clin Invest 67:1263–1269.

    Article  PubMed  CAS  Google Scholar 

  35. Prager R, Kovarik J, Schernthaner G, Woleszczuk W, Willvonseder R: (1983) Peripheral insulin resistance in primary hyperparathyroidism. Metabolism 32:800–805.

    Article  PubMed  CAS  Google Scholar 

  36. Isaac R, Merceron RE, Caillens G, Raymond JP, Ardaillou R: (1978) Effect of parathyroid hormone on plasma prolactin in man. J Clin Endocrinol Metab 47:18–23.

    Article  PubMed  CAS  Google Scholar 

  37. Procci WR, Goldstein AA, Adelstein J, Massry SG: (1981) Sexual dysfunction in the male patient with uremia: A reappraisal. Kidney Int 19:317–323.

    Article  PubMed  CAS  Google Scholar 

  38. Finkelstein FO, Finkelstein SH: (1981) Evaluation of sexual dysfunction of patients with renal failure. Dial and Transplant 10:921–924.

    Google Scholar 

  39. Massry SG, Goldstein DA, Procci WR, Kletzky DA: (1977) Impotence in patients with uremia: A possible role for parathyroid hormone. Nephron 19:305–310.

    Article  PubMed  CAS  Google Scholar 

  40. Barsotti G, Ciardella F, Morelli E, Fioretti P, Melis GB, Paoletti A, Niosi F, Caprioli R, Fosso A, Carbone C, Giovannetti S: (1985) Restoration of blood levels of testosterone in male uremics following a low protein diet supplemented with essential amino acids and keto analogues. Contr Nephrol 49:63–69.

    CAS  Google Scholar 

  41. Mahajan SK, Abbasi AA, Prasad AS, Pabbani P, Briggs WA, McDonald FD: (1982) Effect of oral zinc therapy on gonadal function in hemodialysis patients. Ann Intern Med 97:357–361.

    PubMed  CAS  Google Scholar 

  42. Morley JE, Melmed S: (1979) Gonadal dysfunction in systemic disorders. Metabolism 28: 1051–1073.

    Article  PubMed  CAS  Google Scholar 

  43. Swamy AP, Woolf PD, Cestero RF: (1979) Hypothalamipituitary-ovarian axis in uremic women. J Lab Clin Med 93:1066–1072.

    PubMed  CAS  Google Scholar 

  44. Thaysen JH, Olgaard K, Jensen HG: (1975) Ovarian cysts in women on chronic intermittent haemodialysis. Acta Med Scand 197:433–437.

    Article  PubMed  CAS  Google Scholar 

  45. Ramires G, O’Neill WM, Bloomer HA, Jubiz W: (1977) Abnormalities in the regulation of prolactin in patients with chronic renal failure. J Clin Endocr Metab 45:630–637.

    Google Scholar 

  46. Jackson I: (1982) Thyrotropin-releasing hormone. N Engl J Med 306:145–155.

    Article  PubMed  CAS  Google Scholar 

  47. Ramirez G, O’Neill W, Jubiz W, Bloomer HA: (1976) Thyroid dysfunction in uremia: Evidence for thyroid and hypophyseal abnormalities. Ann Intern Med 84:672–676.

    PubMed  CAS  Google Scholar 

  48. Rao MB, Bay WH, George JM, Hebert LA: (1986) Primary hypothyroidism in chronic renal failure. Clin Nephrol 25:11–14.

    PubMed  CAS  Google Scholar 

  49. Le Roith D, Danovitz G, Treatian S, Spitz IM: (1980) Dissociation of pituitary glycoprotein response to releasing hormones in chronic renal failure. Acta Endocrinol 93:277–282.

    Google Scholar 

  50. Davis FB, Spector DA, Davis PJ, Hirsch BR, Walse JJ, Yoshida K: (1982) Comparison of pituitary-thyroid function in patients with end-stage renal disease and in age- and sex-matched controls. Kidney Int 21:362–364.

    Article  PubMed  CAS  Google Scholar 

  51. Spector DA, Davis PJ, Heldrman JH, Bell B, Utiger RD: (1986) Thyroid function and metabolic state in crhonic renal failure. Ann Intern Med 85:724–730.

    Google Scholar 

  52. Hegedues L, Andersen JR, Poulsen LR, Perrild H, Holm B, Gundtoft E, Hansen JM: (1985) Thyroid gland volume and serum concentrations of thyroid hormones in chronic renal failure. Nephron 40:171–174.

    Article  Google Scholar 

  53. Muls E, Rosseneu M, Lamberigts G, De Moor P: (1985) Changes in the distribution and composition of high-density lipoproteins in primary hypothyroidism. Metabolism 34:345–353.

    Article  PubMed  CAS  Google Scholar 

  54. Burman KD, Smallridge RC, Jones L, Ramos EA, O’Brian OT, Wright SD, Wartofsky L: (1980) Glucagon kinetics in fasting: Physiological elevation in serum 3,5,3’triiodiothyronine increases metabolic clearance rate of glucagon. J Clin Endocrinol Metab 51:1158–1165.

    Article  PubMed  CAS  Google Scholar 

  55. Aronin N, Llotta AA, Shickmanter B, Schyssler GC, Krieger DT: (1981) Impaired clearance of beta-lipotropin in uremia. J Clin Endocrinol Met 53:797–800.

    Article  CAS  Google Scholar 

  56. McDonald WJ, Golper TA, Mass RD, Kendall JW, Porter G, Girard DE, Fisher MD: (1979) Adrenocorticotropin-cortisol axis abnormalities in hemodialysis patients. J Clin Endocrinol Metab 48:92–95.

    Article  PubMed  CAS  Google Scholar 

  57. Rosman PM, Fatag A, Peckham R, Benn R, Tito J, Bacci V, Wallace E: (1982) Pituitary-adrenocortical function in chronic renal failure: blunted suppression and early escape of plasma Cortisol levels after intravenous dexamethasone. J Clin Endocrinol Metab 54:528–533.

    Article  PubMed  CAS  Google Scholar 

  58. Englert E, Brown H, Willardson DG, Wallach S, Simons EL: (1958) Metabolism of free and conjugated 17-hydroxycorticosteroids in subjects with uremia. J Clin Endocrinol Metab 18: 36–48.

    Article  PubMed  CAS  Google Scholar 

  59. Taylor IL, Sells RA, McConnell RB, Dockray GD: (1980) Serum gastrin in patients with chronic renal failure. Gut 21:1062–1065.

    Article  PubMed  CAS  Google Scholar 

  60. Korman MG, Laver MC, Hansky J: (1972) Hypergastrinaemia in chronic renal failure. Br Med J 1:209–210.

    Article  PubMed  CAS  Google Scholar 

  61. Fournier A, Fernere C, Gueris J, Sebert JC, Quichaud J, Bordieri P: (1976) Hypercalcemia with oral calcium carbonate in patients on chronic hemodialysis. Assessment of plasma gastrin and parathyroid hormone. Kidney Int 9:521.

    Google Scholar 

  62. Ramus NI, Fender HR, Rayford PL, Thompson JC: (1975) The effect of transit of the kidney on exogenous CCK. Gastroenterology 68:970.

    Google Scholar 

  63. Samloff IM, Liebman WM, Panitch NM: (1975) Serum group I pepsinogens by radioimmunoassay in control subjects and patients with peptic ulcer. Gastroenterology 69:83–90.

    PubMed  CAS  Google Scholar 

  64. Aronin N, Krieger DT: (1983) Plasma immunoreactive beta-endorphin is elevated in uremia. Clin Endocrinol 18:459–464.

    Article  CAS  Google Scholar 

  65. Aronin N, Llotta AS, Schickmanter B, Schussier GC, Kriger DT: (1981) Impaired clearance of beta-lipotropin in uremia. J Clin Endocrinol Metab 53:797–800.

    Article  PubMed  CAS  Google Scholar 

  66. Smith R, Grossman A, Gaillard R, Clement-Jones V, Ratter S, Mallison J, Lowry PJ, Besser GM, Rees LH: (1981) Studies on circulating met-enkephalin and beta-endotropin: Normal subjects and patients with renal and adrenal disease. Clin Endocrinol 15:281–300.

    Article  Google Scholar 

  67. Kuhn JM, Seurin D, Bertagna X, Hadjiat R, Thieblot P, Girard F: (1984) Les lipotropines (beta-et gamma-LPH) Marqueurs fiables de la fonction corticotrope. Ann Endocrinol 45: 369–374.

    CAS  Google Scholar 

  68. Rosenblatt M: (1987) The endogenous opiate peptide. In: Braunwald E, Isselbacher KJ, Petersdorf RB, Wilson JD, Martin JB, Fauci AS (eds) Harrison’s Principles of Internal Medicine, XI ed., New York: McGraw Hill, pp 378–382.

    Google Scholar 

  69. Faden AI, Holaday JW: (1979) Opiate antagonists: A role in the treatment of hypovolemic shock. Science 205:317–318.

    Article  PubMed  CAS  Google Scholar 

  70. Holaday JW, Faden AI: (1980) Naloxone acts at central opiate receptors to reverse hypotension, hypothermid and hypoventilation in spinal shock. Brain Res 189:295–299.

    Article  PubMed  CAS  Google Scholar 

  71. Willette RN, Krieger AJ, Sapru HN: (1982) Blood pressure and splanchnic nerve activity are reduced by a vagally mediated opioid action. J Cardiovasc Pharmacol 4:1006–1011.

    Article  PubMed  CAS  Google Scholar 

  72. Coburn JW, Slatopolsky E: (1985) Vitamin D, parathyroid hormone, and renal osteodystrophy. In: Brenner BM, Rector FC (eds) The Kidney, 3rd ed. Philadelphia: WB Saunders, pp 1657–1729.

    Google Scholar 

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© 1989 Kluwer Academic Publishers, Boston

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Ciardella, F. (1989). Hormonal Derangements in Chronic Renal Failure. In: Giovannetti, S. (eds) Nutritional Treatment of Chronic Renal Failure. Topics in Renal Medicine, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1583-4_13

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  • DOI: https://doi.org/10.1007/978-1-4613-1583-4_13

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