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Leishmaniasis pp 807-817 | Cite as

Site Specific Antileishmanial Drug Delivery

  • David Hart
  • Jayne Lawrence
Part of the NATO ASI Series book series (NSSA, volume 171)

Abstract

Over the past decade progress has been made towards the rational development of drug delivery vesicles for the treatment of visceral leishmaniasis. After intravenous (IV) administration, foreign colloidal particles, such as phospholipid vesicles (liposomes) and nanoparticles, are rapidly cleared by the macrophages of the reticuloendothelial system (RES) — particularly those residing in the liver and spleen. While this natural distribution may cause serious limitations for the use of colloidal carriers in the treatment of a number of diseases, including solid tumours or metastases and cutaneous leishmaniasis, it offers considerable advantages in the treatment of visceral leishmaniasis.

Keywords

Visceral Leishmaniasis Cutaneous Leishmaniasis Antileishmanial Activity Leishmania Donovani Sodium Stibogluconate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • David Hart
    • 1
  • Jayne Lawrence
    • 1
  1. 1.Drug Delivery Special Interest Group Departments of Biology and PharmacyKing’s College London (KQC)LondonUSA

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