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Leishmaniasis pp 431-439 | Cite as

Histopathogenic Mechanisms in American Cutaneous Leishmaniasis of Mice

  • Amalia Monroy-Ostria
  • Eva Velez-Castro
  • Teresa Monroy-Ostria
Part of the NATO ASI Series book series (NSSA, volume 171)

Abstract

The appearance of specific clinical types of American cutaneous leishmaniasis depends on host genetic factors and the virulence of the parasite. Bradley et al (1979), showed, in mice, that resistance to Leishmania donovani is controlled by autosomic gene localized on chromosome 1, designed at Lsh gene. This gene also controls resistance to Salmonella typhimurium, Mycobacteirum bovis and Mycobacterium lepraemurium in mice. It seems that this gene does not have any effect in Leishmani major and Leishmania mexicana infections. Susceptibility to Leishmania major is controlled by the Scl gene which is found on chromosome 8. It also influences infection by Leishmania mexicana.

Keywords

Visceral Leishmaniasis Serum Antibody Cutaneous Leishmaniasis Soluble Antigen Parasitophorous Vacuole 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Amalia Monroy-Ostria
    • 1
  • Eva Velez-Castro
    • 1
  • Teresa Monroy-Ostria
    • 1
  1. 1.Departamento de InmunologiaEscuela Nacional de Ciencias Biologicas, IPNMexico CityMexico

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