Histopathogenic Mechanisms in American Cutaneous Leishmaniasis of Mice
The appearance of specific clinical types of American cutaneous leishmaniasis depends on host genetic factors and the virulence of the parasite. Bradley et al (1979), showed, in mice, that resistance to Leishmania donovani is controlled by autosomic gene localized on chromosome 1, designed at Lsh gene. This gene also controls resistance to Salmonella typhimurium, Mycobacteirum bovis and Mycobacterium lepraemurium in mice. It seems that this gene does not have any effect in Leishmani major and Leishmania mexicana infections. Susceptibility to Leishmania major is controlled by the Scl gene which is found on chromosome 8. It also influences infection by Leishmania mexicana.
KeywordsVisceral Leishmaniasis Serum Antibody Cutaneous Leishmaniasis Soluble Antigen Parasitophorous Vacuole
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- Monroy, O., Ridley, D.S., Heather, C.J. and Ridley, M.J., 1980, Histological studies of the elimination of Leishmania enriettii from skin lesions in the guinea pig. Br. J. Exp. Path., 61: 601Google Scholar
- Monroy, O.A. 1983, Aspectos histopatologicos relacionados con la respuesta inmun en dos tipos de leishmaniasis., cutanea americana. Tesis Doctoral. Escuela Nacional de Ciencias Biologicas, IPN. Mexico.Google Scholar
- Perez, H., Arredondo, B. and Gonzalez, M. 1977, Comparative study of American cutaneous leishmaniasis in two strains of inbred mice., Infec. Imm., 22: 301Google Scholar
- Zeledon, R., Macoya, G., Ponce, Chaves, F., Murillo, J. and Bonilla, J.A., 1980, Cutaneous leishmaniasis in Honduras Central America., Trans Roy. Soc. Trop. Med. Hyg., 70: 276Google Scholar