Abstract
Most of what we know about immunity to leishmaniasis has been derived from carefully controlled experiments involving a single species of parasite in laboratory animals free from any other infection. However, in nature leishmaniasis is likely to occur concurrently with a wide range of other infections and it is now becoming clear that the immunological responses to one organism can result in a complex interplay capable of affecting the outcome of either or both the interacting infections. The distribution of leishmaniasis coincides with that of malaria over much of its range to such an extent that it was once though that leishmaniasis was a manifestation of malaria. These two diseases must therefore frequently occur together and the possible interactions between them have many important implications. The immunological responses to both leishmaniasis and malaria are complex and it is only within the past few years that it has become possible to begin to understand the intricacies of these responses and the mechanisms for their control. In this paper, I propose to indicate some of the ways in which the immunological responses to both leishmaniasis and malaria can interact and to discuss the consequences of these interactions in the context of both diseases and their control by chemotherapy and vaccination.
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Cox, F.E.G. (1989). Interactions Between Leishmaniasis and Malaria. In: Hart, D.T. (eds) Leishmaniasis. NATO ASI Series, vol 171. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1575-9_37
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DOI: https://doi.org/10.1007/978-1-4613-1575-9_37
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