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Immunodominant Epitopes of the Leishmania Surface Membrane

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Leishmaniasis

Part of the book series: NATO ASI Series ((NSSA,volume 171))

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Abstract

The many different antigens which comprise the surface membrane of leishmania play contrasting roles in parasite-host cell interactions. Some of these antigens influence virulence and infectivity (Kink and Chang, 1987; Kweider et al., 1987; Sacks et al. 1987), others contribute to pathogenecity (Bordier et al., 1982; Anthony et al., 1985) and still others elicit immunosuppressive or immunoprophylactic responses (Slutzky and Greenblatt, 1977; Rodrigues et al., 1986). Thus, successful development of a vaccine against the various species of leishmania which infect man is contingent upon the identity of the defined membrane sub-units which induce protection without causing deleterious side-effects.

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Authors and Affiliations

  1. Department of Pathology, School of Medicine, University of Maryland, Baltimore, Maryland, 21201, USA

    Ronald L. Anthony, John B. Sacci Jr. & Kristina M. Williams

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  1. Ronald L. Anthony
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  2. John B. Sacci Jr.
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  3. Kristina M. Williams
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Editors and Affiliations

  1. King’s College London, London, UK

    D. T. Hart

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© 1989 Springer Science+Business Media New York

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Anthony, R.L., Sacci, J.B., Williams, K.M. (1989). Immunodominant Epitopes of the Leishmania Surface Membrane. In: Hart, D.T. (eds) Leishmaniasis. NATO ASI Series, vol 171. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1575-9_35

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  • DOI: https://doi.org/10.1007/978-1-4613-1575-9_35

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8862-6

  • Online ISBN: 978-1-4613-1575-9

  • eBook Packages: Springer Book Archive

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