Post-Irradiation Alterations In Cerebral Blood Flow

  • Lorris G. Cockerham
  • C. Douglas Forcino
Chapter
Part of the Nato ASI Series book series (NSSA, volume 154)

Abstract

With sufficient dose and qualities of radiation, cell injury causes release of important circulating mediators, cell death and, in those cells which do survive, delayed effects or subtle changes in cell physiology which can sensitize them to other insults. Gastrointestinal damage occurs at the upper end of the intermediate dose range, but hematopoietic damage occurs at the lower end (i.e. 150–200 cGy). However, subtle metabolic and physiologic deficiencies may occur in other organ systems. For example, at intermediate doses of radiation, cardiovascular changes may not be apparent, but these doses may sensitize the individual to sepsis or certain therapeutic drugs which also alter cardiovascular physiology.

Keywords

Permeability Hydrated Ischemia Dopamine Superoxide 

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Lorris G. Cockerham
    • 1
  • C. Douglas Forcino
    • 2
  1. 1.Air Force Office of Scientific ResearchBolling AFBUSA
  2. 2.Armed Forces Radiobiology Research InstituteBethesdaUSA

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