Delayed Effects of Proton Irradiation in the Lens and Integument: A Primate Model

  • A. B. Cox
  • A. C. Lee
  • J. T. Lett
Chapter
Part of the Nato ASI Series book series (NSSA, volume 154)

Abstract

In 1964, the NASA Manned Spacecraft Center Biomedical Research Office and the USAF School of Aerospace Medicine inaugurated an experiment in Space Radiation Biology which now is approaching completion. Rhesus monkeys were irradiated “whole body” with X-rays (2 MeV), electrons (1.6 and 2 MeV), and protons of energies ranging from 10–2300 MeV; e.g. Dalrymple and Lindsay (1966), Krupp (1976), and Yochmowitz et al. (1985). Individual animals that received low and intermediate doses have been monitored for over 20 years, and those animals, together with age-matched controls, are known as the Chronic Radiation Colony (CRC).

Keywords

Argon Cataract Endometriosis Glean 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bergtold, D. S., Cox, A. B., Su, C. M. and Lett, J. T., 1983, Late skin damage in rabbits and monkeys after exposure to particulate radiations, Adv. Space Res., 3:221–229.PubMedCrossRefGoogle Scholar
  2. Cox, A. B., Wood, D. H. and Lett, J. T., 1986, Use of primary cell cultures to measure the late effects in the skins of rhesus monkeys irradiated with protons, Adv. Space Res., 6:217–222.PubMedCrossRefGoogle Scholar
  3. Dalrymple, G. and Lindsay, I. R., 1966, Protons and space travel — an introduction, Radiat. Res., 28:365–371.PubMedCrossRefGoogle Scholar
  4. Hayflick, L. and Moorhead, P. S., 1961, The serial cultivation of human diploid cell strains, Exptl. Cell Res., 25:585–621.CrossRefGoogle Scholar
  5. Keng, P. C., Lee, A. C., Cox, A. B., Bergtold, D. S. and Lett, J. T., 1982. Effects of heavy ions on rabbit tissues: Cataractogenesis, Int. J. Radiat. Biol., 41:127–137.CrossRefGoogle Scholar
  6. Krupp, J. H., 1976, Nine-year mortality experience in proton-exposed Macaca mulatta. Radiat. Res., 67:244–251.PubMedCrossRefGoogle Scholar
  7. Leavitt, D. D., 1985, Retrospective computer analysis of primate head irradiation with 55 MeV Protons, Final Contract Report (Contract No. F33615-83-D-0603 from the USAF to the University of Utah).Google Scholar
  8. Lett, J. T., Cox, A. B., Keng, P. C., Lee, A. C., Su, C. M. and Bergtold, D. S., 1980, Late degeneration in rabbit tissues after irradiation by heavy ions, in: “Life Sciences and Space Research,” xviii, R. Holmquist, ed., Pergamon Press, Oxford.Google Scholar
  9. Lett, J. T., Cox, A. B., Bergtold, D. S., Lee, A. C. and Pickering, J. E., 1984, Late effects from particulate radiations in primate and rabbit tissues, Adv. Space Res., 4:251–256.PubMedCrossRefGoogle Scholar
  10. Lett, J. T., Cox, A. B. and Lee, A. C., 1985, Some perspectives on cataractogenesis from heavy charged particles, Radiat. Res., 104: S201–S207.CrossRefGoogle Scholar
  11. Lett, J. T., Cox, A. B. and Bergtold, D. S., 1986a, Cellular and tissue responses to heavy ions: Basic considerations, Radiat. Environ. Biophys., 25:1–12.CrossRefGoogle Scholar
  12. Lett, J. T., Cox, A. B. and Lee, A. C., 1986b, Cataractogenic potential of ionizing radiations in animal models that simulate man, Adv. Space Res., 6:295–303.CrossRefGoogle Scholar
  13. Milisen, W. B., 1987, “The Effects of Radiation on the Developing Canine Thymus,” Ph.D. Dissertation, Colorado State University, Fort Collins.Google Scholar
  14. Smith, J. R. and Lincoln, D. W., II, 1984, Aging of cells in culture, in “International Review of Cytology,” G. H. Bourne and J. F. Danielli, eds., 89:151–177, Academic Press, New York.Google Scholar
  15. Wood, D. H., Yochmowitz, M., Salmon, Y. L., Eason, R. L. and Boster, R. A., 1983, Proton irradiation and endometriosis, Aviat. Space Environ. Med., 54:718–724.PubMedGoogle Scholar
  16. Wood, D. H., Yochmowitz, M. G., Hardy, K. A. and Salmon, Y. L., 1986a, Animal studies of life shortening and cancer risk from space radiation, Adv. Space Res., 6:275–283.CrossRefGoogle Scholar
  17. Wood, D. H., Yochmowitz, M. G., Hardy, K. A. and Salmon, Y. L., 1986b, Occurrence of brain tumors in rhesus monkeys exposed to 55 MeV protons. Adv. Space Res., 6:213–216.CrossRefGoogle Scholar
  18. Yochmowitz, M. G., Wood, D. H. and Salmon, Y. L., 1985, Seventeen-year mortality experience of proton radiation in Macaca mulatta, Radiat. Res., 102:14–34.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • A. B. Cox
    • 1
  • A. C. Lee
    • 2
  • J. T. Lett
    • 2
  1. 1.Radiation Sciences DivisionUSAF School of Aerospace MedicineUSA
  2. 2.Dept. of Radiology and Radiation BiologyColorado State UniversityFort CollinsUSA

Personalised recommendations