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Haemopoietic Growth Factors as Drugs

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Protein Production by Biotechnology

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Abstract

The process by which a small number of self renewing stems cells give rise to lineage committed progenitors that subsequently proliferate and differentiate to circulating mature blood cells is regulated by a family of glycoproteins known as colony stimulating factors (CSFs). Classification of these CSFs or growth factors, is based on the types of mature cells seen in colonies of bone marrow cells produced in vitro in response to these compounds. Thus, interleukin 3 (IL-3) stimulates the production of mature cells of most of the haemopoietic lineages including granulocytes, macrophages, eosinophils, megakaryocytes, erythroid cells and mast cells. Granulocyte-CSF (G-CSF) and macrophage-CSF (M-CSF) exhibit relative lineage restricted specificity and stimulate the production of granulocytes and macrophages respectively, while granulocyte-macrophage-CSF (GM-CSF) stimulates the production of both granulocytes and macrophages.

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Author information

Authors and Affiliations

  1. CRC Department of Medical Oncology, Paterson Institute & Christie Hospital, Withington, Manchester, UK

    J. H. Scarffe & W. P. Steward

  2. CRC Department of Experimental Hematology, Paterson Institute & Christie Hospital, Withington, Manchester, UK

    N. G. Testa & T. M. Dexter

Authors
  1. J. H. Scarffe
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  2. W. P. Steward
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  3. N. G. Testa
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  4. T. M. Dexter
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Editors and Affiliations

  1. Glaxo Group Research Limited, Greenford Road, Greenford, Middlesex, UB6 OHE, UK

    T. J. R. Harris (Director of Biotechnology) (Director of Biotechnology)

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© 1990 Elsevier Science Publishers Ltd

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Scarffe, J.H., Steward, W.P., Testa, N.G., Dexter, T.M. (1990). Haemopoietic Growth Factors as Drugs. In: Harris, T.J.R. (eds) Protein Production by Biotechnology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1565-0_15

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  • DOI: https://doi.org/10.1007/978-1-4613-1565-0_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8858-9

  • Online ISBN: 978-1-4613-1565-0

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