Abstract
To be able to design a chemical compound that would interact with a characterized receptor on a cell in a specific and predictable way has been the stated goal of pharmacology from very early on. Such rational drug design would in fact be a great achievement. However, we can expect that many new specific drugs will also be discovered by testing of compounds as currently practised. What we propose to do in this chapter is to examine how recent developments in molecular biology have provided several important techniques which can be used to study the interactions of drugs with specific receptor subtypes and how these same systems can be used to study the structure of specific receptors. Hopefully this will lead to the goal of rational drug design as well as provide new and more specific screening procedures for new drugs.
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Pritchett, D.B., Seeburg, P.H. (1990). The Role of Molecular Biology in Drug Discovery and Design. In: Harris, T.J.R. (eds) Protein Production by Biotechnology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1565-0_14
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