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Stunning of the Myocardium: An Update

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Stunning, Hibernation, and Calcium in Myocardial Ischemia and Reperfusion

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Summary

When severely ischemic myocardium is reperfused, prolonged myocardial dysfunction—a phenomenon named myocardial stunning—frequently occurs. Stunning also occurs in a variety of other situations. These include myocardium located adjacent to infarcted tissue, transient increase in myocardial O2 demands in the presence of incomplete coronary obstruction, during both systole and diastole, in isolated perfused hearts rendered ischemic or anoxic, and in a variety of clinical situations, such as following ischemic arrest in cardiac surgery, thrombolytic reperfusion, and after episodes of severe ischemia in Prinzmetal’s angina or unstable angina. Although the fundamental mechanism(s) responsible for myocardial stunning has not been elucidated, in experimental preparations calcium antagonists, free-radical scavengers, and neutrophil depletion have each been found to be helpful in minimizing it.

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Authors
  1. Eugene Braunwald
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Editors and Affiliations

  1. University of Cape Town, Cape Town, South Africa

    Lionel H. Opie MD, DPhil. (Professor of Medicine, Visiting Professor) (Professor of Medicine, Visiting Professor)

  2. Division of Cardiology, Stanford University Medical Center, Stanford, California, USA

    Lionel H. Opie MD, DPhil. (Professor of Medicine, Visiting Professor) (Professor of Medicine, Visiting Professor)

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© 1992 Kluwer Academic Publishers

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Braunwald, E. (1992). Stunning of the Myocardium: An Update. In: Opie, L.H. (eds) Stunning, Hibernation, and Calcium in Myocardial Ischemia and Reperfusion. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1517-9_2

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  • DOI: https://doi.org/10.1007/978-1-4613-1517-9_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-7923-1793-7

  • Online ISBN: 978-1-4613-1517-9

  • eBook Packages: Springer Book Archive

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