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Prolonged Storage of Adult and Newborn Red Cells

  • N. Meyerstein
Part of the Developments in Hematology and Immunology book series (DIHI, volume 24)

Abstract

Prolonged storage of red blood cells induces structural and metabolic changes, known as “storage lesion” [1]. This causes impaired cellular function and a decreased survival time after transfusion [2]. Suitable preservation media may maintain ATP contents and improve in vivo survival [3]. Recently a new preservation medium was composed by Meryman et al, consisting of a hypotonic solution with respect to non permeant solutes [4]. Ammonium chloride, adenine, glucose, mannitol, citrate and phosphate were included in this medium [4]. Unexpectedly, this medium augmented ATP levels and maintained them above initial values for 9 weeks, as well as prolonged in vivo survival at acceptable values, for up to 18 weeks.

Keywords

Ammonium Chloride Prolonged Storage Hypotonic Solution Adult Cell Osmotic Fragility 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers, Boston 1990

Authors and Affiliations

  • N. Meyerstein

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