Prolonged Storage of Adult and Newborn Red Cells
Prolonged storage of red blood cells induces structural and metabolic changes, known as “storage lesion” . This causes impaired cellular function and a decreased survival time after transfusion . Suitable preservation media may maintain ATP contents and improve in vivo survival . Recently a new preservation medium was composed by Meryman et al, consisting of a hypotonic solution with respect to non permeant solutes . Ammonium chloride, adenine, glucose, mannitol, citrate and phosphate were included in this medium . Unexpectedly, this medium augmented ATP levels and maintained them above initial values for 9 weeks, as well as prolonged in vivo survival at acceptable values, for up to 18 weeks.
KeywordsGlutathione Citrate Adenosine Mannitol Agglomeration
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