Alterations of Membrane Proteins in Cardiac Hypertrophy

  • D. Charlemagne
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 116)


Hypertrophy of the heart is an adaptive mechanism to an increase in hemodynamic work. During this process, development without multiplication of the cardiac myocytes occurs and new sarcomeres are added to improve the contractility. As shown by Anversa et al. in compensatory hypertrophy of the rat (1,2), the overall result of the membrane development is an increase of the surface area parallel to the degree of hypertrophy which maintains a constant surface/volume ratio. However, some specialized membrane structures undergo a preferential development like the T-tubules (a 107% increase for the T-tubules as compared to a 33% for the sarcolemma (SL)) and the sarcoplasmic reticulum (SR) (a two fold increase). In this review on the membrane proteins of the hypertrophied myocyte, we shall take this into account to estimate their density of the receptors and their total number per myocyte or per left ventricle. We report that three types of regulation occur with enhanced, unchanged or decreased density leading to increased or unchanged total number of membrane proteins.


Sarcoplasmic Reticulum Aortic Stenosis Cardiac Hypertrophy Pressure Overload Inotropic Response 
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© Kluwer Academic Publishers 1990

Authors and Affiliations

  • D. Charlemagne
    • 1
  1. 1.INSERM U 127Hopital LariboisièreParisFrance

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