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Involvement of Sodium-Calcium Exchange in Cardiac Pathology

  • Chapter
Subcellular Basis of Contractile Failure

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 116))

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Abstract

Transsarcolemmal Ca2+ movements are crucial for force development in the heart. One transsarcolemmal Ca2+ transport pathway exchanges Ca2+ for Na+. Under physiological conditions, this exchange appears to occur primarily in the direction of calcium leaving the cell for sodium entering the cell (1). Thus, sodium-calcium exchange may play a role in the relaxation phase of excitation-contraction coupling in the heart under normal conditions. However, the involvement of sodium-calcium exchange in cardiac pathology is not as well defined. The purpose of the present treatise is to review the current literature on this subject from two scientific methodological approaches: i)pharmacological studies which employ drugs aimed at altering appropriate cellular ion transport pathways, and ii)biochemical studies using isolated sarcolemmal membranes. In addition, the mechanisms which may be responsible for the change in sodium-calcium exchange will be discussed.

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Authors and Affiliations

  1. Ion Transport Laboratory, Division of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, and the Department of Physiology, University of Manitoba, Winnipeg, Canada, R2H 2A6

    G. N. Pierce & T. G. Maddaford

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  1. G. N. Pierce
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  2. T. G. Maddaford
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Borivoj Korecky Naranjan S. Dhalla

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© 1990 Kluwer Academic Publishers

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Pierce, G.N., Maddaford, T.G. (1990). Involvement of Sodium-Calcium Exchange in Cardiac Pathology. In: Korecky, B., Dhalla, N.S. (eds) Subcellular Basis of Contractile Failure. Developments in Cardiovascular Medicine, vol 116. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1513-1_6

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  • DOI: https://doi.org/10.1007/978-1-4613-1513-1_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8813-8

  • Online ISBN: 978-1-4613-1513-1

  • eBook Packages: Springer Book Archive

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