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Hormonal and Non-Hormonal Regulation of Ca2+ Current and Adenylate Cyclase in Cardiac Cells

  • Rodolphe Fischmeister
  • Pierre-François Mery
  • Alvin Shrier
  • Catherine Pavoine
  • Véronique Brechler
  • Françoise Pecker
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 116)

Abstract

The influx of Ca2+ ions through transmembrane Ca2+ channels is fundamental in many aspects of cardiac function. Regulation of the heart beat by noradrenaline and acetylcholine (ACh) is in part mediated by the effects of these neurotransmitters on calcium current, ICa (1). β-adrenergic stimulation of ICa is mediated by a guanine-nucleotide binding protein, Gs (2), which triggers the activation of adenylate cyclase (AC) and in turn stimulates cAMP-dependent phosphorylation of Ca2+ channels (1,3). Gs has also been shown to directly activate Ca2+ channels (4). This latter mechanism, however, may play only a minor role in the physiological response to noradrenaline since the effects of β-adrenergic agonists on ICa were mimicked by external application of cAMP, its analogues or phosphodiesterase inhibitors (5), forskolin (6) [a direct activator of AC (7)], and by intracellular application of cAMP (8,9) or the catalytic subunit of cAMP-dependent protein kinase (PKA; ref. 8).

Keywords

Adenylate Cyclase Calcium Current External Solution Maximal Stimulation Ventricular Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • Rodolphe Fischmeister
    • 1
  • Pierre-François Mery
    • 1
  • Alvin Shrier
    • 1
    • 2
  • Catherine Pavoine
    • 3
  • Véronique Brechler
    • 3
  • Françoise Pecker
    • 3
  1. 1.Laboratoire de Physiologie Cellulaire Cardiaque, INSERM U-241Université de Paris-SudOrsayFrance
  2. 2.Department of PhysiologyMcGill UniversityMontrealCanada
  3. 3.INSERM U-99Hôpital Henri-MondorCréteilFrance

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