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Dietary N-3 Polyunsaturated Fatty Acids and Ischemic Heart Disease

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Book cover Subcellular Basis of Contractile Failure

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 116))

Abstract

Epidemiological studies have indicated that diets containing fish, fish products, or products from other marine animals are beneficial in the prevention of cardiovascular disease (1–5). Modification of several risk factors for the development of atherosclerosis (high levels of plasma triglyceride and total cholesterol, low levels of plasma HDL cholesterol, high aggregability of platelets, leukocyte and monocyte reactivity, high viscosity of blood and, possibly, hypertension) by the n-3 polyunsaturated fatty acids (PUFA) eicosapentanoic (EPA) and docosahexanoic acid (DHA), abundantly present in marine oils, most likely contribute to this prevention (4,6–10). The mechanisms by which EPA and DHA modify these factors are not well understood. Several of the effects may be mediated through changes in prostanoid formation, e.g. by a competitive inhibition of production of arachidonic acid-derived thromboxane A2 (TXA2) and prostacyclin (PGI2) or by an increase of production of EPA-derived prostanoids (TXA3 and PGI3).

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Authors and Affiliations

  1. Department of Biochemistry I, Thoraxcenter, Erasmus University Rotterdam, 3000 DR, Rotterdam, The Netherlands

    J. M. J. Lamers

  2. Laboratory for Experimental Cardiology, Thoraxcenter, Erasmus University Rotterdam, 3000 DR, Rotterdam, The Netherlands

    L. M. A. Sassen, J. M. Hartog & P. D. Verdouw

  3. Facolta di Medicina e Chirurgia dell’Universita di, Instituto di Chimica Biologica, Bologna, Italy

    C. Guarnieri

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  1. J. M. J. Lamers
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  2. L. M. A. Sassen
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  3. J. M. Hartog
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  4. C. Guarnieri
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  5. P. D. Verdouw
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Borivoj Korecky Naranjan S. Dhalla

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Lamers, J.M.J., Sassen, L.M.A., Hartog, J.M., Guarnieri, C., Verdouw, P.D. (1990). Dietary N-3 Polyunsaturated Fatty Acids and Ischemic Heart Disease. In: Korecky, B., Dhalla, N.S. (eds) Subcellular Basis of Contractile Failure. Developments in Cardiovascular Medicine, vol 116. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1513-1_15

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