Skip to main content
SpringerLink
Log in

Antisense Nucleic Acid Analogues as Potential Antiviral Agents

  • Chapter
Herpesviruses, the Immune System, and AIDS

Part of the book series: Developments in Medical Virology ((DIMV,volume 6))

Abstract

Antisense oligodeoxyribonucleotides and nuclease resistant, phosphate-modified oligonucleotide analogues can be used to inhibit virus gene expression both in vitro and in cell culture. Oligomers targeted to bind to functional regions of viral mRNAs such as the initiation codon region or splice junction regions of pre-mRNA, can interfere with mRNA expression in a sequence specific manner. Antisense oligonucleotides and oligonucleotide analogues have been used to inhibit virus protein synthesis and replication in cells infected with vesicular stomatitis virus, herpes simplex virus and human immunodeficiency virus. Because the inhibitory effects of the oligomers depend upon the oligomer sequence, it appears that antisense oligomers could be used as research tools to study and manipulate virus gene expression in cell culture and could be developed into highly specific and effective antiviral agents.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Stebbing, N. Pharmac. Ther., 6:291–332, 1979.

    Article  CAS  Google Scholar 

  2. Stein, C.A. and Cohen, J.A. Cancer Res., 48:2659–2668, 1988.

    PubMed  CAS  Google Scholar 

  3. Miller, P.S. and Ts’o, P.O.P. Ann. Reports Med. Chem., 23:295–304, 1988.

    Article  CAS  Google Scholar 

  4. van der Krol, A.R. and Stuitje, J.N.N.M. Bio Techniques 6:958–975, 1988.

    Google Scholar 

  5. Perdue, M.L., Borchelt, D. and Resnick, R.J. J. Biol. Chem. 257:655-1-6555, 1982.

    Google Scholar 

  6. Blake, K.R., Murakami, A. and Miller, P.S. Biochemistry 24:6132–6138, 1985.

    Article  PubMed  CAS  Google Scholar 

  7. Cazenave, C., Loreau, N., Toulme, J.J. and Helene, C. Biochimie 68:1063–1069, 1986.

    Article  PubMed  CAS  Google Scholar 

  8. Shatkin, S.H. and Liebhaber, S.A. J. Biol. Chem. 21:16018–16025, 1986.

    Google Scholar 

  9. Toulme, J.J., Krisch, H.M., Loreau, N., Thuong, N.T. and Helene, C. Proc. Natl. Acad. Sci. (USA) 83:1227–1231, 1986.

    Article  CAS  Google Scholar 

  10. Walder, J.A., Eder, P.S., Engman, D.M., Crentanano, S.T., Walder, R.Y., Knutzon, D.S., Dorfman, D.M. and Donelson, J.E. Science 233:569–571, 1986.

    Article  PubMed  CAS  Google Scholar 

  11. Cornelissen, A.W.C.A., Verspieren, M.P., Toulme, J.J., Swinkels, B.W. and Borst, P. Nucleic Acids Res. 14:5605–5614, 1986.

    Article  PubMed  CAS  Google Scholar 

  12. Haeuptle, M.T., Frank, R. and Dobberstein, B. Nucleic Acids Res. 14:1427–1448, 1986.

    Article  PubMed  CAS  Google Scholar 

  13. Holt, J.T., Redner, R.L and Nienhuis, W. Mol. Cell. Biol. 8:963–973, 1988.

    PubMed  CAS  Google Scholar 

  14. Zamecnik, P.C., Goodchild, J., Taguchi, Y. and Sarin, P.S. Proc. Natl. Acad. Sci. (USA), 83:4143–4146, 1986.

    Article  CAS  Google Scholar 

  15. Wickstrom, E., Simonet, W.S., Medlock, K. and Ruiz-Robles, I. Biophys. J. 49:15–17, 1986.

    Article  PubMed  CAS  Google Scholar 

  16. Minshull, J. and Hunt, T. Nucleic Acids Res. 14:6433–6451, 1986.

    Article  PubMed  CAS  Google Scholar 

  17. Heikkila, R., Schwab, G., Wickstrom, E., Lake, S.L., Pluznik, D.H., Watt, R. and Neckers, L.M. Nature 328:445–449. 1987.

    Article  PubMed  CAS  Google Scholar 

  18. Maher III, L.J. and Dolnick, B.J. Arch. Biochem. Biophys. 253:214–220, 1987.

    Article  PubMed  CAS  Google Scholar 

  19. Gupta, K.C. J. Biol. Chem. 262:7492–7496, 1987.

    PubMed  CAS  Google Scholar 

  20. Cazenave, C., Lorequ, N., Thuong, N.T., Toulme, J.J. and Helene, C. Nucleic Acids Res. 15:4717–4736, 1987.

    Article  PubMed  CAS  Google Scholar 

  21. Goodchild, J., Carroll III, E. and Greenberg, J.R. Arch. Biochem. Biophys. 263:401–409, 1988.

    Article  PubMed  CAS  Google Scholar 

  22. Goodchild, J., Agrawal, S., Civeira, M.P., Sarin, P.S., Sun, D. and Zamecnik, P.C. Proc. Natl. Acad. Sci. (USA) 85:5507–5511, 1988.

    Article  CAS  Google Scholar 

  23. Shuttleworth, J. and Colman, A. EMBO J. 7:427–434, 1988.

    PubMed  CAS  Google Scholar 

  24. Crum, C., Johnson, J.D., Nelson, A. and Roth, D. Nucleic Acids Res. 16:4569–4581, 1988.

    Article  PubMed  CAS  Google Scholar 

  25. R.Y. Walder and J.A. Walder. Proc. Natl. Acad. Sci. (USA) 85:5011–5015, 1988.

    Article  CAS  Google Scholar 

  26. Morgan, A.R. and Wells, R.D. J. Mol. Biol. 37:63–80, 1968.

    Article  PubMed  CAS  Google Scholar 

  27. Wells, R.D., Collier, D.A., Hanvey, J.C., Shimizu, M. and Wohlrab, F., FASEB J. 2:2939–2949, 1988.

    PubMed  CAS  Google Scholar 

  28. Strobel, S.A., Moser, H.E. and Dervan, P.B. J. Am. Chem. Soc. 110:7927–7929, 1988.

    Article  CAS  Google Scholar 

  29. Fedorova, O.S., Knorre, D.G., Podust, L.M. and Zarytova, V.F. FEBS Letters 228:273–276, 1988.

    Article  PubMed  CAS  Google Scholar 

  30. Francois, J.C., Saison-Behmoaras, T. and Helene, C. Nucleic Acids Res. 16:11431–11440, 1988.

    Article  PubMed  CAS  Google Scholar 

  31. Povsic, T.J. and Dervan, P.B. J. Am. Chem. Soc. 111:3059–3061, 1989.

    Article  CAS  Google Scholar 

  32. Cooney, M., Czernuszewicz, G., Postel, E.H., Flint, S.J. and Hogan, M.E. Science 241:456–459, 1988.

    Article  PubMed  CAS  Google Scholar 

  33. Morvan, F., Rayner, B., Imbach, J.L, Chan, D.K. and Lown, J.W. Nucleic Acids Res. 14:5019–5035, 1987.

    Article  Google Scholar 

  34. Sun, J.S., Asseline, U., Rouzaud, D., Montenay-Garestier, T., Thuong, N.T., and Helene, C. Nucleic Acids Res. 15:6149–6158, 1987.

    Article  PubMed  CAS  Google Scholar 

  35. Praseuth, D., Chassignol, M., Takasugi, M., Le Doan, T., Thuong, N.T., and Helene, C. J. Mol. Biol. 196:939–942, 1987.

    Article  CAS  Google Scholar 

  36. Morvan, F., Rayner, B., Imbach, J.-L, Lee, M., Hartley, J.A., Chang, D.K. and Lown, J.W. Nucleic Acids Res. 15:7027–7044, 1987.

    Article  PubMed  CAS  Google Scholar 

  37. Thuong, T., Asseline, U., Roig, V., Takasugi, M. and Helene, C. Proc. Natl. Acad. Sci. (USA) 84:5129–5133, 1987.

    Article  CAS  Google Scholar 

  38. Morvan, F., Rayner, B., Leonetti, J.P. and Imbach, J.L. Nucleic Acids Res. 16:833–847, 1988.

    Article  PubMed  CAS  Google Scholar 

  39. Durand, M., Maurizot, J.C., Thuong, N.T. and Helene, C. Nucleic Acids Res. 16:5039–5053, 1988.

    Article  PubMed  CAS  Google Scholar 

  40. Cazenave, C., Chevrier, M., Thuong, N.T. and Helene, C. Nucleic Acids Res. 15:10507–10521, 1987.

    Article  PubMed  CAS  Google Scholar 

  41. C. Gagnor, C., Bertrand, J.R., Thenet, S., Lemaitre, M., Morvan, F., Rayner, B., Malvy, C., LeBleu, B., Imbach, J.L and Paoletti, C. Nucleic Acids Res. 15:10419–10436, 1987.

    Article  PubMed  CAS  Google Scholar 

  42. C. Helene, C. and Thuong, N.T. Biochem. Pharm. 37:1797–1798,1988.

    Article  PubMed  CAS  Google Scholar 

  43. Stec, W.J., Zon, G., Egan, W. and Stec, B. J. Am. Chem. Soc. 108:6077–6079, 1984.

    Article  Google Scholar 

  44. Connolly, B.A., Potter, B.V.L., Eckstein, F., Pingoud, A. and Grotjahn, L. Biochemistry 23:3443–3453, 1984.

    Article  PubMed  CAS  Google Scholar 

  45. LaPlanche, L.A., James, T.L., Powell, C., Wilson, W.D., Uznanski, B., Stec, W.J., Summers, M.F. and Zon, G. Nucleic Acids Res. 14:9081–9093, 1986.

    Article  Google Scholar 

  46. Agarwal, K.L. and Riftina, F. Nucleic Acids Res. 6:3009–3024, 1979.

    Article  PubMed  CAS  Google Scholar 

  47. Miller, P.S., Yano, J., Yano, E., Carroll, C., Jayaraman, K. and Ts’o, P.O.P. Biochemistry 18:5134–5142, 1979.

    Article  PubMed  CAS  Google Scholar 

  48. Agrawal, S., Goodchild, J., Civeira, M.P., Thornton, A.H., Sarin, P.S. and Zamecnik, P.C. Proc. Natl. Acad. Sci. (USA) 85:7079–7083, 1988.

    Article  CAS  Google Scholar 

  49. Miller, P.S., McParland, K.B., Jayaraman, K. and Ts’o, P.O.P. Biochemistry 20:1874–1880, 1981.

    Article  PubMed  CAS  Google Scholar 

  50. Marcus-Sekura, C.J., Woener, A.M., Shinozuka, K., Zon, G. and Quinnan, Jr.,G.V. Nucleic Acids Res. 15:5749–5763, 1987.

    Article  PubMed  CAS  Google Scholar 

  51. Jayaraman, K., McParland, K., Miller, P. and Ts’o, P.O.P. Proc. Natl. Acad. Sci. 78:1537–1542,1981.

    Article  PubMed  CAS  Google Scholar 

  52. Murakami, A., Blake, K.R., and Miller, P.S. Biochemistry 24:4041–4046, 1985.

    Article  PubMed  CAS  Google Scholar 

  53. Froehler, B., Ng, P. and Matteucci, M. Nucleic Acids Res. 16:4831–4839, 1988.

    Article  PubMed  CAS  Google Scholar 

  54. Sarin, P.S., Agrawal, S., Civeira, M.P., Goodchild, J., Ikeuchi, T. and Zamecnik, P.C. Proc. Natl. Acad. Sci. (USA) 85:7448–7451, 1988.

    Article  CAS  Google Scholar 

  55. Jager, A., Levy, M.J. and Hecht, S.M. Biochemistry 27:7237–7246, 1988.

    Article  PubMed  CAS  Google Scholar 

  56. Letsinger, R.L, Singman, C.N., Histand, G. and Salunkhe, M. J. Am. Chem. Soc. 110:4470–4471. 1988.

    Article  CAS  Google Scholar 

  57. Lin, S.B., Blake, K.R., Miller, P.S. and Ts’o, P.O.P. Biochemistry 28: 1054–1061, 1989.

    Article  PubMed  CAS  Google Scholar 

  58. Quartin, R.S. and Wetmur, J.G. Biochemistry 28:1040–1047, 1989.

    Article  PubMed  CAS  Google Scholar 

  59. Miller, P.S., Dreon, N., Pulford, S.M. and McParland, K.B. J. Biol. Chem. 255:9659–9665, 1980.

    CAS  Google Scholar 

  60. Walder, J.A. Gene Dev. 2:502–504, 1988.

    Article  PubMed  CAS  Google Scholar 

  61. Stephenson M.L. and Zamecnik, P.C. Proc. Natl. Acad. Sci. (USA) 75:285–288, 1978.

    Article  CAS  Google Scholar 

  62. Agris, C.H., Blake, K.R., Miller, P.S., Reddy, M.P. and Ts’o, P.O.P. Biochemistry 25:6268–6275, 1986.

    CAS  Google Scholar 

  63. Lawson, T.G., Lee, K.A., Maimone, M.M., Abramson, R.D., Dever, T.E., Merrick, W.C. and Thach, R.E. Biochemistry 28:4729–4734, 1989.

    Article  PubMed  CAS  Google Scholar 

  64. Kawasaki, E.S. Nucleic Acids Res. 13:4991–5004, 1985.

    Article  PubMed  CAS  Google Scholar 

  65. Zamecnik, P.C. and Stephenson, M.L. Proc. Natl. Acad. Sci. (USA) 75:280–284, 1978.

    Article  CAS  Google Scholar 

  66. Lemaitre, M., Bayard, B. and Lebleu, B. Proc. Natl. Acad. Sci. (USA) 84:648–652, 1987.

    Article  CAS  Google Scholar 

  67. Smith, C.C., Aurelian, L., Reddy, M.P., Miller, P.S. and Ts’o, P.O.P. Proc. Natl. Acad. Sci. (USA) 83:2787–2791, 1986.

    Article  CAS  Google Scholar 

  68. Kulka, M., Smith, C.C., Aurelian, L., Fishelevich, R., Meade, K., Miller, P. and Ts’o, P.O.P. Proc. Natl. Acad. Sci. (USA) 86, in press 1989.

    Google Scholar 

  69. Matsukura, M., Shinozuka, K., Zon, G., Mitsuya, H., Reitz, M., Cohen, J.S. and Broder, S. Proc. Natl. Acad. Sci. (USA) 84:7706–7710, 1987.

    Article  CAS  Google Scholar 

  70. Majumdar, C., Stein, C.A., Cohen, J.S., Broder, S. and Wilson, S.H. Biochemistry 28:1340–1346, 1989.

    Article  PubMed  CAS  Google Scholar 

  71. Zaia, J.A., Rossi, J.J., Murakawa, G.J., Spallone, P.A., Stephens, D.A., Kaplan, B.E., Eritja, R., Wallace, R.B. and Cantin, E.M. J. Virol. 62:3914–3917, 1988.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, The Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland, 21205, USA

    Paul S. Miller

Authors
  1. Paul S. Miller
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The University of Maryland, Baltimore, USA

    Laure Aurelian M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Kluwer Academic Publishers

About this chapter

Cite this chapter

Miller, P.S. (1990). Antisense Nucleic Acid Analogues as Potential Antiviral Agents. In: Aurelian, L. (eds) Herpesviruses, the Immune System, and AIDS. Developments in Medical Virology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1507-0_14

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1507-0_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8810-7

  • Online ISBN: 978-1-4613-1507-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation