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Abstract

There are many effective drug treatments for the management of patients with systemic hypertension (1). However, an ideal antihypertensive drug, which is both efficacious and free of adverse reactions, has yet to be introduced. This chapter will focus on new antihypertensive drugs at early stages of development (Table 1). These new agents have a considerable therapeutic potential, and represent highly selective pharmacologic approaches for the prevention and treatment of hypertension.

Keywords

Angiotensin Convert Enzyme Atrial Natriuretic Peptide Plasma Renin Activity Atrial Natriuretic Factor Renin Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Cressman, M.D., Vlasses, P.H. Med. Clinics N. Amer. 72 (2): 373–397, 1988.Google Scholar
  2. 2.
    Rotmensch, H.H., Vlasses, P.H., Ferguson, R.K. Med. Clinics N. Amer. 72 (2): 399–425, 1988.Google Scholar
  3. 3.
    Borek, B., Charlap, S., Frishman, W.H. Med. Clinics N. Amer. 73 (2): 315–338, 1989.Google Scholar
  4. 4.
    Haber, E., Hui, K.Y. In: SPIOBA Hypertension: Pathophysiology, Diagnosis and Treatment (Eds J.H. Laragh, B.M. Brenner), Raven Press, New York, 1990, pp 2343–2350.Google Scholar
  5. 5.
    Taylor, D.G., Kaplan, H.R. SPIOBA In: New Therapeutic Strategies in Hypertension (Eds N.M. Kaplan, B.M. Brenner, J.H. Laragh), Raven Press, New York, 1989, pp 125–139.Google Scholar
  6. 6.
    Dzau, V.J. J. Cardiovasc. Pharmacol. A53–A57, 1985.Google Scholar
  7. 7.
    Umezawa, H., Aoyagi, T., Morishima, H., Matsuzaki, M., Hamada, M., Takeuchi, T. J. Antibiot. 23.: 259–262, 1970.PubMedGoogle Scholar
  8. 8.
    Greenlee, W.J. Pharmac. Res. 4: 364–374, 1987.CrossRefGoogle Scholar
  9. 9.
    Blaine, E.H., Schorn, T.W., Boger, J. Hypertension 6 (Suppl 1): I-111–I-118, 1984.Google Scholar
  10. 10.
    Webb, D.J., Manhem, P.J.O., Ball, S.G., Inglis, G., Leckie, B.J., Lever, A.F., Morton, J.J., Robertson, J. I.S., Murray, G.D., Menard, J., Hallett, A., Jones, D. M., Szelke, M. J. Hypertens. 3: 653–658, 1985.PubMedCrossRefGoogle Scholar
  11. 11.
    Zusman, R.M., Burton, J., Christensen, D., Dodds, A., Haber, E. Trans. Assoc. Am. Physicians 96: 365–374, 1983.PubMedGoogle Scholar
  12. 12.
    Timmermans, P.B.M., Carini, D.J., Chiu, A.T., et al. SPIOBA In; Hypertension: Pathophysiology, Diagnosis and Treatment (Eds J.H. Laragh, B.M. Brenner), Raven Press, New York, 1990, pp 2351–2360.Google Scholar
  13. 13.
    DeForrest, J.M., Waldron, T.L., Powell, J.R., Floyd, D.M., Sundeen, J.E. J. Cardiovasc. Pharmacol. 9: 154–159, 1987.CrossRefGoogle Scholar
  14. 14.
    Allan, G., Cambridge, D., Hardy, G.W., Follenfant, M.J. Br. J. Pharmac. 90: 609–615, 1987.Google Scholar
  15. 15.
    Atlas, S.A., Laragh, J.H. SPIOBA In: Hypertension: Pathophysiology, Diagnosis and Treatment (Eds J.H. Laragh, B.M. Brenner), Raven Press, New York, 1990, pp 861–883.Google Scholar
  16. 16.
    Cody, R.J., Atlas, S.A., Laragh, J.H., Kubo, S.H., Covit, A.B., Ryman, K.S., Shaknovitch, A., Pondolfino, K., Clark, M., Camargo, M.J.F., Scarborough, R.M., Lewicki, J.A. J. Clin. Invest. 78: 1362, 1986.CrossRefGoogle Scholar
  17. 17.
    Garcia, R., Thibault, G., Seidah, N.G., Lazure, C., Cantin, M., Genest, J., Chretien, M. Biochem. Biophys. Res. Comm. 126: 178–184, 1985.PubMedCrossRefGoogle Scholar
  18. 18.
    Maack, T., Suzuki, M., Almeida, F.A., Nusenzveig, D., Scarborough, R.M., McEnroe, G.A., Lewicki, J.A. Science 238: 675–678, 1987.PubMedCrossRefGoogle Scholar
  19. 19.
    Koepke, J., Tyler, L., Trapani, A., Bovy, P., Speak, K., Olins, G., Blaine, E. FASEB J. 2: A527, 1988.Google Scholar
  20. 20.
    Scarborough, R.M., Schenk, D.B., McEnroe, G.A., Arfsten, A., Kang, L.L., Schwartz, K., Lewicki, J.A. J. Biol. Chem. 261: 12960–12964, 1986.Google Scholar
  21. 21.
    Seymour, A.A., Delaney, N.G., Swerdel, J.N., Fennel, S.A., Neubeck, R., Druckman, S.P., Cushman, D.W., DeForrest, J.M. FASEB J. 2: A936, 1988.Google Scholar
  22. 22.
    Cohen, M.L. Drug Dev. Res. 9: 249–258, 1986.CrossRefGoogle Scholar
  23. 23.
    Buckingham, R.E. Br. J. Pharmacol. 93: 541–552, 1988.Google Scholar
  24. 24.
    Cowley, A.J., Wynne, R.D., Hampton, J.R. J. Hypertens. 2 (Suppl 3): 547–549, 1984.Google Scholar
  25. 25.
    Cook, N.S., Quast, U., Hof, R.P., Baumliji, Y., Pally, C. J. Cardiovasc. Pharmacol. 11: 90–99, 1988.CrossRefGoogle Scholar
  26. 26.
    Byyny, R.L., Nies, A.S., LoVerde, M.E., Mitchell, W.D. Clin. Pharmacol. Ther. 42: 50–57, 1987.PubMedCrossRefGoogle Scholar
  27. 27.
    Izzo, J.L., Licht, M.R., Smith, R.J., Larrabee, P.S., Radke, K.J., Kallay, M.C. Am. J. Cardiol. 60: 303–308, 1987.PubMedCrossRefGoogle Scholar
  28. 28.
    Vandenburg, M.J., Woodward, S.M.A., Stewart-long, P., Tasker, T., Pilgrim, A.J., Dews, I.M., Fairhurst, G. J. Hypertens. 5 (Suppl 5): S193–195, 1987.Google Scholar
  29. 29.
    Okin, S., Huberfeld, S.I., Frishman, W.H., Soberman, J., Laifer, L., Greenberg S., Lapsker, J., Charlap, S., Strom, J.A. J. Clin. Pharmacol. 28: 1008–1016, 1988.Google Scholar
  30. 30.
    Frishman, W.H., Okin, S., Huberfeld, S. Med. Clinics N. Amer. 72(2): 501–522, 1988.Google Scholar
  31. 31.
    Hosie, J., Stott, D.J., Robertson, J.I.S., Ball, S.G. J. Cardiovasc. Pharmacol. 10 (Suppl 3): S86–S88, 1987.Google Scholar
  32. 32.
    Hilditch, A., Drew, G.M. Clin. & Exper. Hyper. A9(5–6): 853–872, 1987.Google Scholar
  33. 33.
    Cavero, I., Thiry, C, Pratz, J., Lawson, K. Clin. & Exper. Hyper A9(5–6): 931–952, 1987.CrossRefGoogle Scholar
  34. 34.
    Hieble, J. P., Owen, D.A.A., Harvey, C.A., Blumberg, A.L., Valocik, R.E., DeMarinis, R.M. Clin. & Exper. Hyper. A9(5–6): 889–912, 1987.Google Scholar
  35. 35.
    Allgaier, C., Hertting, G., Kugelgen, O.U. Br. J. Pharmacol. 90: 403–412, 1987.PubMedGoogle Scholar
  36. 36.
    Paton, D.M. J. Auton. Pharmacol. 1: 287–290, 1981.CrossRefGoogle Scholar
  37. 37.
    Herlihy, J.T., Bookman, E.L., Berne, R.M., Rubio, R. Am. J. Physiol. 230(5): 1239–1243, 1976.PubMedGoogle Scholar
  38. 38.
    Ryan, M.J., Mertz, T., Potoczak, R., Taylor, D., Kaplan, H.R. FASEB J. 2: A606, 1988.Google Scholar
  39. 39.
    Taylor, D.G., Bruns, F., Bjork, F., Cohen, D., Singer, R., Olszewski, B.J., Ryan, M.J., Trivedi, B., Kaplan, H.R. FASEB J. 2: A606, 1988.Google Scholar
  40. 40.
    Murad, F. J. Clin. Invest. 78: 1–5, 1986.PubMedCrossRefGoogle Scholar
  41. 41.
    Rapoport, R.M., Waldman, S.A., Ginsburg, R., Molina, C.R., Murad, F. J. Cardiovasc. Pharmacol. 10: 82–89, 1987.CrossRefGoogle Scholar
  42. 42.
    Takayanagi, R., Imada, T., Grammer, R.T., Misono, K.S., Naruse, M., Inagami, R. J. Hypertens. 4 (Suppl 3): S303-S-307, 1986.Google Scholar
  43. 43.
    Martin, W., Furchgott, R.F., Villani, G.M., Jothianandan, D. J. Pharmacol. Exp. Ther. 237: 539–547, 1986.Google Scholar

Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • William H. Frishman
    • 1
    • 2
  1. 1.The Hospital of the Albert Einstein College of MedicineBronxUSA
  2. 2.The Albert Einstein College of MedicineBronxUSA

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