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Endocrine and Systemic Manifestation of Brain Tumors in Children

  • Chapter
Management of Childhood Brain Tumors

Part of the book series: Foundations of Neurological Surgery ((FONS,volume 3))

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Abstract

After leukemias, brain tumors are the second most common malignancy of childhood. Tumors within or above the sella turcica often profoundly alter endocrine function through involvement of the hypothalamic—pituitary axis. Tumors remote from the hypothalamic—pituitary axis may produce endocrine dysfunction by infiltration to the axis or through increased intracranial pressure. Metastatic malignancy in the pituitary associated with disseminated neoplasms is rare during childhood, occurring more frequently among adults. However, in children the most common malignancies associated with metastasis to the pituitary are histiocytosis X, leukemia, and lymphoma. Cranial irradiation for childhood head and neck tumors and leukemias are becoming a more frequent cause of acquired hypopituitarism.

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Authors
  1. Silva Arslanian
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  2. Thomas P. Foley Jr.
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  3. Peter A. Lee
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Editors and Affiliations

  1. Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA

    Melvin Deutsch M.D. (Professor) (Professor)

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© 1990 Kluwer Academic Publishers

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Arslanian, S., Foley, T.P., Lee, P.A. (1990). Endocrine and Systemic Manifestation of Brain Tumors in Children. In: Deutsch, M. (eds) Management of Childhood Brain Tumors. Foundations of Neurological Surgery, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1501-8_5

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