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Long-term Neuropsychologic and Intellectual Sequelae in Brain Tumor Patients

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Management of Childhood Brain Tumors

Part of the book series: Foundations of Neurological Surgery ((FONS,volume 3))

Abstract

With increasingly aggressive multimodality treatment, the ability to cure or at least obtain long-term survival for significant numbers of children with primary or secondary brain tumors is becoming more commonplace, with further success on the horizon. With this increasing survival rate comes the responsibility to evaluate closely the subtle and more overt long-term effects on the children themselves—not only physical and functional effects, but behavioral, neuropsychological, and intellectual effects as well. Long-term physical and hormonal effects are easily evaluated and quantitated, and early intervention may modify the long-term effects on the child. Other long-term sequelae, however, are less easily defined and can require a comprehensive range of tests to even establish a general area of deficiency, let alone to determine the cause and effect mechanisms.

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References

  1. Abramson N, Raben M, Cavanaugh PT: Brain tumors in children. Radiology 112:669–672, 1974.

    PubMed  CAS  Google Scholar 

  2. Bamford FN, Jones PM, Pearson D, Ribeiro MB, Shalet SM, Beardwell CG: Residual disabilities in children treated for intracranial spaceoccupying lesions. Cancer 37:1149–1152, 1976.

    Article  PubMed  CAS  Google Scholar 

  3. Bloom HJG, Wallace ENK, Henk JM: The treatment and prognosis of medulloblastoma in children. Am J Roetgenol 105:43–62, 1969.

    CAS  Google Scholar 

  4. Bender L: Visual Motor Gestalt Test. New York: The American Orthopsychiatric Association, Inc., 1946, p. 307.

    Google Scholar 

  5. Jastak J, Jastak S: Wilde Range Achievement Test. Wilmington, DE Jastak Associates, Inc., 1978, pp 1–42.

    Google Scholar 

  6. McCarthy D: The McCarthy Scales of Children’s Abilities. New York: The Psychological Corp., 1970, pp 55–138.

    Google Scholar 

  7. Wechsler D: Wechsler Adult Intelligence Scale. New York: The Psychological Corp., 1955, pp 33–110.

    Google Scholar 

  8. Wechsler D: Wechsler Intelligence Scale for Children—Revised. New York: The Psychological Corp., 1974, pp 65–187.

    Google Scholar 

  9. Whitt JK, Wells RJ, Laurie MM, et al.: Cranial radiation in childhood ALL. Am J Dis Child 138:730–736, 1984.

    PubMed  CAS  Google Scholar 

  10. Soni SS, Marten GW, Pitner SE, Duenas DA, Powazek M: Effects of central nervous system irradiation on neuropsychologic functioning of children with acute lymphocytic leukemia. N Engl J Med 293:113–118, 1975.

    Article  PubMed  CAS  Google Scholar 

  11. Vervoza MS, AurAur RJA, Simone JV, Husta HO, Pinkel DP: Five years after central nervous system irradiation of children with leukemia. Int J Radiat Oncol Biol Phys 1:209–215, 1976.

    Article  Google Scholar 

  12. Obetz SW, Smithson WA, Groover RV, et al.: Neuropsychologic follow up study of children with ALL. Am J Pediatr Hematol Oncol 1: 207–213, 1979.

    Article  PubMed  CAS  Google Scholar 

  13. Ivnik RJ, Colligan RC, Obetz SW: Neuropsychologic performance among children in remission from ALL. J Dev Behav Pediatr 2: 29–34, 1981.

    Article  PubMed  CAS  Google Scholar 

  14. Robison L, Nesbit M, Sather H: Intellectual function in long-term survivors of childhood ALL. Proc Am Assoc Cancer Res 23:107, 1982.

    Google Scholar 

  15. Eiser C, Lansdown R: Retrospective study of intellectual development in children treated for ALL. Arch Dis Child 52:525–529, 1977.

    Article  PubMed  CAS  Google Scholar 

  16. Eiser C: Intellectual abilities among survivors of childhood leukemia as a function of CNS irradiation. Arch Dis Child 53:391–395, 1978.

    Article  PubMed  CAS  Google Scholar 

  17. Meadows AT, Gordon J, Littman P, et al.: Pattern of cognitive dysfunctions in children with ALL treated with cranial radiation. Proc AACR ASCO 21:350 (abstract), 1980.

    Google Scholar 

  18. Meadows AJ, Massari DJ, Fergusson J, et al.: Decline in IQ scores and cognitive dysfunction in children with acute lymphoblastic leukemia treated with cranial irradiation. Lancet 2: 1015–1018, 1981.

    Article  PubMed  CAS  Google Scholar 

  19. Jamoun L: Are cognitive and educational development affected by age at which prophylactic therapy is given in ALL? Arch Dis Child 58: 953–958, 1983.

    Article  Google Scholar 

  20. Pfefferbaum-Levine B, Copeland DR, Fletcher JM: Neuro-psychologic assessment of long term survivor of childhood leukemia. Am J Pediatr Hematol Oncol 6:123–128, 1984.

    Article  PubMed  CAS  Google Scholar 

  21. Rowland JH, Glidewell OJ, Sibley RF, et al.: Effects of different forms of CNS prophylaxis on neuropsychologic function in childhood leukemia. J Clin Oncol 2:1327–1335, 1984.

    PubMed  CAS  Google Scholar 

  22. Stehbens JA, Kisker CT: Intelligence and achievement testing in childhood cancer— three years post diagnosis. J Dev Behav Pediatr 5:184–188, 1984.

    Article  PubMed  CAS  Google Scholar 

  23. Pavlosky S, Fishman N, Arizaga R, Castano J, Chamoles N, Leigurarda R, Moreno R: Neuropsychological study in patients with ALL—Two different CNS therapies—Cranial XRT plus IT methotrexate vs IT methotrexate alone. Am J Pediatr Hematol Oncol 5:79–86, 1983.

    Google Scholar 

  24. Moss HA, Nannis ED, Poplack DG: The effects of prophylactic treatment of the central nervous system on the intellectual functioning of children with ALL. Am J Med 71:47–52, 1981.

    Article  PubMed  CAS  Google Scholar 

  25. Twaddle V, Britton PG, Craft AC, et al.: Intellectual function after treatment for leukemia or solid tumors. Arch Dis Child 58:949–952, 1983.

    Article  PubMed  CAS  Google Scholar 

  26. Clements SD: Minimal Brain Dysfunction in Children. NINDB Monograph #3. Washington DC: U.S. Department of Health, Education, and Welfare, 1966.

    Google Scholar 

  27. Gutjahr P, Walter B: IQ and cognitive function in long-term surviving of childhood. Lancet 2:1278–1279, 1981.

    Article  PubMed  CAS  Google Scholar 

  28. Moss HA, Nannis ED, Hubbard VS: A comparison of intellectual abilities between children with cystic fibrosis and their healthy siblings (abstract). Annual Meeting Cystic Fibrosis Foundation, Atlanta, Georgia, May 1, 1979.

    Google Scholar 

  29. Gjerris F: Clinical aspects and long-term prognosis, of intra-cranial tumors in infants and childhood. Dev Med Child Neurol 18:145–159, 1976.

    Article  PubMed  CAS  Google Scholar 

  30. Hirsch JF, Renier D, Czernichow P, et al.: Medulloblastoma in childhood. Survival and functional results. Acta Neurochir 48:1–15, 1979.

    Article  CAS  Google Scholar 

  31. Clopper RR: Postsurgical IQ and behavioral data on 20 patients with childhood craniopharyngioma. Psychoneuroendocrinology 2: 365–372, 1977.

    Article  PubMed  CAS  Google Scholar 

  32. Danoff BF, Cowchock S, Marquette C, et al.: Assessment of the long-term effects of primary radiation therapy for brain tumors in children. Cancer 49:1580–1586, 1982.

    Article  PubMed  CAS  Google Scholar 

  33. Spunberg JJ, Cheng CH, Goldman M, et al.: Quality of long-term survival following, irradiation for intracranial tumors in children under the age of two. Int J Radiat Oncol Biol Phys 7:727–736, 1981.

    Article  PubMed  CAS  Google Scholar 

  34. Kun L, Mulhern RK, Crisco JJ: Neuropsychological function in children with brain tumors II: Serial studies intellectual, emotional and academic function. J Neurosurg 58:1–6, 1983.

    Article  PubMed  CAS  Google Scholar 

  35. McNemar G: Psychological Statistics. New York and London: Wiley and Sons, 1961, p. 373.

    Google Scholar 

  36. Kun LE, Mulhern RK: Neuropsychological function in children with brain tumors. Serial studies of intellect and time after treatment. Am J Clin Oncol 6:651–656, 1983.

    PubMed  CAS  Google Scholar 

  37. Duffner PK, Cohen ME, Thomas PRM: Late effects of treatment on the intelligence of children with posterior fossa tumors. Cancer 51: 233–237, 1983.

    Article  PubMed  CAS  Google Scholar 

  38. Duffner PK, Cohen ME, Thomas PR, Lanslay SB: Long-term effects of cranial irradiation on the central nervous system. Cancer 56: 1841–46, 1985.

    Article  PubMed  CAS  Google Scholar 

  39. Silverman CL, Palkes H, Talent B, et al.: Late effects of radiotherapy on patients with cerebellar medulloblastoma. Cancer 54:35–40, 1984.

    Article  Google Scholar 

  40. Hochberg FH, Slotnick B: Neuropsychological impairment in astrocytoma survivors. Neurology 30:172–177, 1980.

    PubMed  CAS  Google Scholar 

  41. Meyer-Bahlburg HF, Fernman JA, MacGul-Ivray MH: Growth hormone deficiency, brain development and intelligence. Am J Dis Child 132:565–572, 1978.

    PubMed  CAS  Google Scholar 

  42. Cavazzuti V, Fischer EG, Welch K, et al.: Neurological and psychological sequelae following different treatments of craniopharyngioma in childhood. J Neurosurg 59:409–417, 1983.

    Article  PubMed  CAS  Google Scholar 

  43. Butler RW, Dickinson WA, Kaltok C: The comparative effects of organic brain disease and cerebral blood flow and measured intelligence. Ann Neurol 13:155–159, 1983.

    Article  PubMed  CAS  Google Scholar 

  44. Frytak S, Earnest F, O’Neill BP, et al.: Magnetic resonance imaging for neurotoxicity in long term survivors of carcinoma. Mayo Clin Proc 60:803–811, 1985.

    PubMed  CAS  Google Scholar 

  45. Peylan-Ramu N, Poplack DG, Pizzo PA, Adornato BT, DiChiro G: Abnormal CT scans of the brain in asymptomatic children with acute lymphocytic leukemia after prophylactic treatment of the central nervous system with radiation and intrathecal chemotherapy. N Engl J Med 298:815–818, 1978.

    Article  PubMed  CAS  Google Scholar 

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© 1990 Kluwer Academic Publishers

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Silverman, C.L., Thomas, P.R.M. (1990). Long-term Neuropsychologic and Intellectual Sequelae in Brain Tumor Patients. In: Deutsch, M. (eds) Management of Childhood Brain Tumors. Foundations of Neurological Surgery, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1501-8_23

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  • DOI: https://doi.org/10.1007/978-1-4613-1501-8_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8807-7

  • Online ISBN: 978-1-4613-1501-8

  • eBook Packages: Springer Book Archive

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