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Advanced Basal and Squamous Cell Carcinomas of the Skin of the Head and Neck

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Carcinomas of the Head and Neck

Part of the book series: Cancer Treatment and Research ((CTAR,volume 52))

Abstract

Although the skin of the head and neck accounts for less than 10 percent of the body surface area, a large proportion of cutaneous malignancies occur in this region. This factor is directly related to the greater amount of actinic radiation this region receives compared with the remainder of the skin surface. In the more than 500,000 patients with nonmelanoma skin cancer treated every year [1], basal and squamous cell carcinomas, in a ratio of 3 to 1, are the most frequently encountered histologic types; they usually occur on areas such as the nose, ear, and forehead that receive the greatest amount of sun exposure [2]. As a result of greater sun exposure in occupational and recreational activities, the incidence of skin cancer seems to be increasing and the initial age at presentation decreasing. About 50 percent of patients are older than 65, and 25% have multiple lesions [3]. The median delay between occurrence of initial symptoms to the patient’s presentation for treatment is three years. Skin cancer incidence also varies with geography, climate, and skin color, fair-skinned persons of Scandinavian descent being especially susceptible.

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References

  1. Haynes HA, Mead KW, Goldwyn RM: Cancers of the skin. In: Devita Jr VT, Helaman S, Rosenberg SA (eds), Cancer: Principles and Practice of Oncology, vol 2. Philadelphia: Lippincott, pp 1343–1369, 1985.

    Google Scholar 

  2. Andrade R, Gumport SL, Popkin G, Reese R: Cancer of the skin, vol 2. Philadelphia: WB Saunders, pp 899–949, 1976.

    Google Scholar 

  3. Whitaker DC: Clinical evaluation of tumors of the skin. In: Thawley SE, Panje WR (eds), Comprehensive Management of Head and Neck Tumors, vol 2. Philadelphia: WB Saunders, pp 1158–1172, 1987.

    Google Scholar 

  4. Silverberg E, Lubera JA: Cancer statistics, 1988. Ca 38:5–22, 1988.

    PubMed  CAS  Google Scholar 

  5. Panje WR, Ceilley RI: The influence of embryology of the mid—face on the spread of epithelial malignancies. Laryngoscope 89:1914–1920, 1979.

    Article  PubMed  CAS  Google Scholar 

  6. Le vine H: Cutaneous carcinoma of the head and neck: management of massive and previously uncontrolled lesions. Laryngoscope 93:87–105, 1983.

    CAS  Google Scholar 

  7. Hauben DJ, Zirkin H, Mahler D, Sacks M: The biologic behavior of basal cell carcinoma: Part I. Plast Reconstr Surg 69:103–109, 1982.

    Article  PubMed  CAS  Google Scholar 

  8. Scanlon EF, Volkmer DD, Oviedo MA, et al.: Metastatic basal cell carcinoma. J. Surg Oncol 15:171–180, 1980.

    Article  PubMed  CAS  Google Scholar 

  9. Brownstein MH, Rabinowitz AD: The precursors of cutaneous squamous cell carcinoma. Int J Derm 18:1–16, 1979.

    Article  PubMed  CAS  Google Scholar 

  10. Immerman SC, Scanlon EF, Christ M, Knox KL: Recurrent squamous cell carcinoma of the skin. Cancer 51:1537–1540, 1983.

    Article  PubMed  CAS  Google Scholar 

  11. Moller R, Reymann F, Hou-Jensen K: Metastases in dermatological patients with squamous cell carcinoma. Arch Dermatol 115:703–705, 1979.

    Article  PubMed  CAS  Google Scholar 

  12. Jackson GL, Ballantyne AJ: Role of parotidectomy for skin cancer of the head and neck. Am J Surg 142:464–469, 1981.

    Article  PubMed  CAS  Google Scholar 

  13. Cottle WI: Perineurals invasion by squamous cell carcinoma. J Dermatol Surg Oncol 8:589–600, 1982.

    Google Scholar 

  14. Goepfert HG, Dichtel WJ, Medina JE, Lindberg RD, Luna MD: Perineural invasion in squamous cell skin carcinoma of the head and neck. Am J Surg 148:542–547, 1984.

    Article  PubMed  CAS  Google Scholar 

  15. Larson DL, Rodin AE, Roberts DK, O’Steen WK, Rapperport AS, Lewis SR: Perineural lymphatics: myth or fact. Am J Surg 112:448–492, 1966.

    Article  Google Scholar 

  16. Jackson RJ, Adams RH: Horrifying basal cell carcinoma: A study of 33 cases and a comparison with 435 non—horror cases and a report on four metastatic cases. J Surg Oncol 5:431–463, 1973.

    Article  PubMed  CAS  Google Scholar 

  17. Wolf DJ, Zitelli JA: Surgical margins for basal cell carcinoma. Arch Dermatol 123:340–344, 1987.

    Article  PubMed  CAS  Google Scholar 

  18. Koplin L, Zarem HA: Recurrent basal cell carcinoma. Plast Reconstr Surg 65:656–664, 1980.

    Article  PubMed  CAS  Google Scholar 

  19. Mohs FE: Chemosurgery microscopically controlled method of cancer excision. Arch Surg 42:279–295, 1941.

    CAS  Google Scholar 

  20. Hanke CW, Weisberger EC: Invasion of the parotid gland by basal cell carcinoma: Implications for therapy. J Dermatol Surg 12:849–852, 1986.

    CAS  Google Scholar 

  21. Panje WR, Bumstead RM, Ceilley RI: Secondary intention healing as an adjunct to the reconstruction of the mid—facial defects. Laryngoscope 90:1148–1154, 1980.

    Article  PubMed  CAS  Google Scholar 

  22. Hogstrom KR, Fields RS: Use of the CT in electron beam treatment planning: current and future development. In: Ling CC and Morton RJ (eds), Computed Tomography in Radiation Therapy. New York: Raven Press, p 241, 1983.

    Google Scholar 

  23. Tapley NduV: Skin and lips. In: Tapley NduV (ed), Clinical Application of Electron Beam, New York: John Wiley, pp 93–122, 1976.

    Google Scholar 

  24. Chobe R, McNeese MD, Weber R, Fletcher GH, Kong JP: Radiation therapy for carcinoma of the nasal vestibule. Otolaryngol 98:67–71, 1988.

    CAS  Google Scholar 

  25. Sinesi C, McNeese MD, Peters LJ, Goepfert H, King J, Mills MD: Electron beam therapy for eyelid carcinomas. Head Neck Surg 10:31–37, 1987.

    Article  PubMed  CAS  Google Scholar 

  26. Goepfert H, Guillamondegui OM, Jesse RH, Lindbert RD: Squamous cell carcinoma of nasal vestibule. Arch Otolaryngol Head Neck Surg 10:8–10, 1974.

    Google Scholar 

  27. Wong CS, Cummings BJ: The place of radiation therapy in the treatment of squamous cell carcinoma for the nasal vertibule. A review. Acta Oncol 27:203–208, 1988.

    Article  PubMed  CAS  Google Scholar 

  28. Holoye PY, Byers RM, Gard DA, Goepfert H, Guillamondegui OM, Jesse RH: Combination chemotherapy of head and neck cancer. Cancer 42:1661–1669, 1978.

    Article  PubMed  CAS  Google Scholar 

  29. Guthrie Jr TH, McElveen LJ, Porubsky ES, Harmon JD: Cisplatin and doxorubicin: an effective chemotherapy in the treatment of advanced basal cell and squamous carcinoma of the skin. Cancer 55:1629–1632, 1985.

    Article  PubMed  Google Scholar 

  30. Rahal M, Sadek H, Azli M, Cvitkovic E, Djemma A, Wendling JL, Filali T, Avril JP: Advanced loco—regional skin carcinoma. Primary chemotherapy with cisplatin (CDDP), bleomycin (BLM) and 5 fluorouracil (5 FU). Proc ASCO 8:293, 1989.

    Google Scholar 

  31. Lippman SM, Kessler JF, Meyskens Fl: Retinoids as preventive and therapeutic anticancer agents. Cancer Treat Rep 71:391–405, 493–515, 1987.

    Google Scholar 

  32. Lotan R: Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. Biochim Biophys Acta 605:33–91, 1980.

    PubMed  CAS  Google Scholar 

  33. Brand N, Petkovich M, Krust A, Chambon P, de The Hugues, Marchio A, Tiollais P, Dejean A: Identification of a second human retinoic acid receptor. Nature 332:850–853, 1988.

    CAS  Google Scholar 

  34. Kraemer KH, DiGiovanna JJ, Moshell AN, et al.: Prevention of skin cancer in xeroderma pigmentosum with the use of oral isotretinoin. N Engl J Med 318:1633–1637, 1988.

    Article  PubMed  CAS  Google Scholar 

  35. Lippman SM, Kessler JF, Al-Sarraf M, et al.: Treatment of advanced squamous cell carcinoma of the head and neck with isotretinoin: A phase II randomized trial. Invest New Drugs 6:13–17, 1988.

    Article  Google Scholar 

  36. Takaku F: Clinical trials and cancer risk in Japan. JNCI 73:1483–1485, 1984.

    PubMed  CAS  Google Scholar 

  37. Thatcher N, Blackledge G, Crowther D: Advanced recurrent squamous cell carcinoma of the head and neck: Results of a chemotherapeutic regimen with adriamycin, bleomycin, 5—fluorouracil, methotrexate, and vitamin A. Cancer 46:1324–1328, 1980.

    Article  PubMed  CAS  Google Scholar 

  38. Belisario JC: Recent advances in topical cytotoxic therapy of skin cancer and pre-cancer. In: Melanoma and Skin Cancer, Proceeding of the International Cancer Conference. Sydney, pp 349–365, 1972.

    Google Scholar 

  39. Bollag W, Ott F: Vitamin A acid in benign and malignant epithelial tumors of the skin. Acta Derm Venereol (Stockh) (suppl) 74:163–166, 1975.

    CAS  Google Scholar 

  40. Grupper CH, Berretti B: Cutaneous neoplasia and etretinate. In: Spitzy KH, Karrer K (eds), Proceedings of the 13th International Congress of Chemotherapy. Vienna, VH Egermann, pp 201/24–27, 1983.

    Google Scholar 

  41. Schumacher A, Stuttgen G: Vitamin A—saure hyperkeratosen epithelialia thumoren und akne. Dtsch Med Wochenschr 40:1547–1551, 1971.

    Article  Google Scholar 

  42. Sankowski A, Janik P, Bogacka-Zatorska E: Treatment of basal cell carcinoma with 13—cis retinoic acid. Neoplasma 31:615–618, 1984.

    PubMed  CAS  Google Scholar 

  43. Peck GL, Olsen TG, Butkus D, et al.: Treatment of basal cell carcinomas with 13—cis retinoic acid (abstr). Proc Am Assoc Cancer Res 20:56, 1979.

    Google Scholar 

  44. Meyskens Jr Fl, Gilmartin E, Albert DS, et al.: Activity of isotretinoin against squamous cell cancers and preneoplastic lesions. Cancer Treat Rep 66:1315–1319, 1982.

    PubMed  Google Scholar 

  45. Braun-Falco O, Galosi A, Dorn M, et al.: Tumor Prophylaxe bei Xeroderma Pigmentosum mit Aromatischem Retinoid (Ro 10–9359). Hautarzt 33:445–448, 1982.

    PubMed  CAS  Google Scholar 

  46. Lippman SM, Meyskens F: Treatment of advanced squamous cell carcinoma of the skin with isotretinoin. Ann Intern Med 107:499–501, 1987.

    PubMed  CAS  Google Scholar 

  47. Levine N, Miller RC, Meyskens F Jr: Oral isotretinoin therapy: use in a patient with multiple cutaneous squamous cell carcinoma and keratoacanthomas. Arch Dermatol 120:1215–1217, 1984.

    Article  PubMed  CAS  Google Scholar 

  48. Kingston T, Gaskell S, Markss R: The effects of a novel potent oral retinoid (Rol3–6298) in the treatment of multiple solar keratoses and squamous cell epithelioma. Eur J Cancer Clin Oncol 19:1201–1205, 1983.

    Article  PubMed  CAS  Google Scholar 

  49. Taguchi T: Clinical studies of recombinant interferon alfa—2a (RoferonR-A) in cancer patients. Cancer 57:1705–1708, 1986.

    Article  PubMed  CAS  Google Scholar 

  50. Edwards L, Le vine N, Weidner M, Piepkorn M, Smiles K: Effect of intralesional a2—interferon on actinic keratoses. Arch Dermatol 122:779–782, 1986.

    Article  PubMed  CAS  Google Scholar 

  51. Greenway HT, Cornell RC, Tanner DJ, Peets E, Bordin GM, Nagi C: Treatment of basal cell carcinoma with intralesional interferon. J Am Acad Dermatol 15:437–443, 1986.

    Article  PubMed  CAS  Google Scholar 

  52. Ikic D, Padovan I, Brodarec I, Knezevic M, Soos E: Application of human leukocyte interferon in patients with tumors of the head and neck. Lancet 1:1025–1027, 1981.

    PubMed  CAS  Google Scholar 

  53. Padovan I, Brodarec I, Ikic D, Knezevic M, Soos E: Effect of interferon in therapy of skin and head and neck tumors. J Cancer Res Clin Oncol 100:295–310, 1981.

    Article  PubMed  CAS  Google Scholar 

  54. Lippman SM, Hong WK: Differentiation therapy for head and neck cancer: in Multimodality Therapy for Head and Neck Cancer, Snow G, Clark JR (eds). N.Y.: Springer-Verlag, in press.

    Google Scholar 

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© 1990 Kluwer Academic Publishers, Boston

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Weber, R.S., Lippman, S.M., McNeese, M.D. (1990). Advanced Basal and Squamous Cell Carcinomas of the Skin of the Head and Neck. In: Jacobs, C. (eds) Carcinomas of the Head and Neck. Cancer Treatment and Research, vol 52. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1499-8_5

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  • DOI: https://doi.org/10.1007/978-1-4613-1499-8_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8806-0

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