Abstract
The first labeling of antibodies with radioactive isotopes was reported by Pressman [1] in 1948. A radioiodine was employed. Over the next two decades, extensive development of the chemistry of iodination methods and the general utility of iodine-based radioimmunoassays resulted in radioiodination becoming a familiar tool in most biochemistry laboratories. Thus, shortly after the development of monoclonal antibodies by Kohler and Milstein [2], these exquisitely specific immunoproteins were soon being explored as vehicles for targeting of iodine radionuclides to tumors for gamma camera imaging or for therapy [3,4].
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Gansow, O.A., Brechbiel, M.W., Mirzadeh, S., Colcher, D., Roselli, M. (1990). Chelates and antibodies: Current methods and new directions. In: Goldenberg, D.M. (eds) Cancer Imaging with Radiolabeled Antibodies. Cancer Treatment and Research, vol 51. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1497-4_7
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DOI: https://doi.org/10.1007/978-1-4613-1497-4_7
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