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Intraperitoneal delivery of monoclonal antibodies

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Cancer Imaging with Radiolabeled Antibodies

Part of the book series: Cancer Treatment and Research ((CTAR,volume 51))

Abstract

The use of intact radiolabeled antibodies, administered intravenously, in experimental animals and in humans has been complicated by the relatively low tumor/background ratios and the low absolute tumor uptakes achieved [1]. While antibody fragments enhance the tumor/background ratios (at the cost of lower absolute tumor uptake), as does the systemic administration of polyclonal anti-mouse antibodies, these tumor/nontumor ratios often remain relatively low, as do absolute tumor uptakes [2–6]. While these facts have not prevented radioimmunodetection from being a viable clinical undertaking, particularly as radiolabeling methods with a higher photon flux are becoming available and with the use of background subtraction, a method of delivering more antibody to tumors and less to normal tissues would be most valuable [7–10].

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  1. Richard L. Wahl
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Editors and Affiliations

  1. Center for Molecular Medicine and Immunology, University of Medicine and Dentistry of New Jersey, 1 Bruce St., Newark, New Jersey, 07103, USA

    David M. Goldenberg Sc.D., M.D.

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© 1990 Kluwer Academic Publishers

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Wahl, R.L. (1990). Intraperitoneal delivery of monoclonal antibodies. In: Goldenberg, D.M. (eds) Cancer Imaging with Radiolabeled Antibodies. Cancer Treatment and Research, vol 51. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1497-4_6

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  • DOI: https://doi.org/10.1007/978-1-4613-1497-4_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8805-3

  • Online ISBN: 978-1-4613-1497-4

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