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Experimental model systems for antibody targeting and radioimmunodetection

  • Chapter
Book cover Cancer Imaging with Radiolabeled Antibodies

Part of the book series: Cancer Treatment and Research ((CTAR,volume 51))

Abstract

The development of radiolabeled antibodies for clinical imaging and therapy has relied extensively on a variety of animal models. The design and use of animal models in radiotracer studies, including radiolabled antibodies, has been reviewed [1]. The first animal studies in the field of radioimmunodetection (RAID) were performed in the late 1940s and early 1950s. In a study to determine if anti-organ antibodies could localize specifically to the target organ, Pressman and Keighly [2] were the first to show localization of kidney following intravenous injection of I-131-labeled rabbit antibody against rat kidney. Subsequent studies confirmed that antibodies could be prepared with specificities against other organs, such as adrenals, ovary, lung, and small intestine [3]. Encouraged by these findings that organ-specific antibodies could be developed, investigations began to determine if tumor-specific antibodies could be generated. Pressman and Korngold [4] demonstrated selective tumor targeting in mice bearing the Wagner-osteogenic mouse sarcoma cell line. One of the earliest antigens used to localize humans tumors was fibrin [5], and I-131-labeled antibodies to fibrin were used in two patients for therapy [6]. However, it was recognized that more extensive investigations were needed to make this method useful for the early detection of tumors in humans.

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Authors
  1. Rosalyn D. Blumenthal
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  2. Robert M. Sharkey
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  3. David M. Goldenberg
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  1. Center for Molecular Medicine and Immunology, University of Medicine and Dentistry of New Jersey, 1 Bruce St., Newark, New Jersey, 07103, USA

    David M. Goldenberg Sc.D., M.D.

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Blumenthal, R.D., Sharkey, R.M., Goldenberg, D.M. (1990). Experimental model systems for antibody targeting and radioimmunodetection. In: Goldenberg, D.M. (eds) Cancer Imaging with Radiolabeled Antibodies. Cancer Treatment and Research, vol 51. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1497-4_3

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