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Augmentation of tumor antigen expression by recombinant human interferons: Enhanced targeting of monoclonal antibodies to carcinomas

  • Chapter
Cancer Imaging with Radiolabeled Antibodies

Part of the book series: Cancer Treatment and Research ((CTAR,volume 51))

Abstract

The advent of hybridoma technology has provided an unlimited supply of monoclonal, ‘monospecific’ antibodies (Mab) that has fueled an unprecedented surge in the study of tumor immunology and biology [1]. For the first time, investigators have at their disposal a continuous source of pure antibody that makes possible the identification and extensive characterization of a wide variety of tumor antigens expressed by human carcinomas, melanomas, leukemias, and lymphomas. Subsequent studies have also led to the development of novel assays using Mabs for tumor diagnosis [2–5], as well as a variety of clinical protocols demonstrating radioimmunolocalization of an antibody to occult lesions in a variety of cancer patients [6–15]. In addition to these clinical studies, the use of immunohistochemical techniques, radioimmunoassays (RIA), Western blotting, and other experimental analyses have led to a better understanding of some of the basic principles that characterize tumor antigen expression.

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Authors
  1. John W. Greiner
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  2. Fiorella Guadagni
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  3. Patricia Horan Hand
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  4. Sidney Pestka
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  5. Philip Noguchi
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  6. Paul B. Fisher
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  7. Jeffrey Schlom
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Editors and Affiliations

  1. Center for Molecular Medicine and Immunology, University of Medicine and Dentistry of New Jersey, 1 Bruce St., Newark, New Jersey, 07103, USA

    David M. Goldenberg Sc.D., M.D.

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© 1990 Kluwer Academic Publishers

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Greiner, J.W. et al. (1990). Augmentation of tumor antigen expression by recombinant human interferons: Enhanced targeting of monoclonal antibodies to carcinomas. In: Goldenberg, D.M. (eds) Cancer Imaging with Radiolabeled Antibodies. Cancer Treatment and Research, vol 51. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1497-4_21

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  • DOI: https://doi.org/10.1007/978-1-4613-1497-4_21

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