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Radioimmunoguided surgery: A new intraoperative approach to the detection of tumor

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Cancer Imaging with Radiolabeled Antibodies

Part of the book series: Cancer Treatment and Research ((CTAR,volume 51))

Abstract

Tumors marked with a radiolabeled antibody may be located by two different techniques. The first is the diagnostic use of a gamma camera to produce an image. The second is the clinical use of a gamma-sensitive probe to ‘home in’ on tumors intraoperatively. Since the two techniques are quite different, it is not surprising that they differ in advantages, limitations, and design.

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References

  1. Myers, W.G., and Vanderleeden, J.C. (1980) Radioiodine-125. J. Nucl. Med. 149–164.

    Google Scholar 

  2. Aitken, D.R., Hinkle, G.H., Thurston, M.O., Martin, D.T., Olsen, J.O., Haagensen, D.E., Houchens, D.P., and Martin, E.W., Jr. (1984) A gamma detecting probe for radio-immune detection of CEA-producing tumors: Successful experimental use and clinical case report. Dis. Colon Rectum 27:279–282.

    Article  PubMed  CAS  Google Scholar 

  3. Aitken, D.R., Thurston, M.O., Hinkle, G.H., Jr., Martin, D.T., Haagensen, D.E., Jr., Houchens, D., Tuttle, S.E., and Martin, E.W., Jr. (1984) Portable gamma probe for radioimmune localization of experimental colon tumor xenografts. J. Surg. Res. 36:480–489.

    Article  PubMed  CAS  Google Scholar 

  4. Hinkle, G., Houchens, D., Miller, E., Nines, R., Nabi, H., Thurston, M., Tuttle, S., Mojzisik, C., and Martin, E., Jr. (1987) Preferential localization of antibody combinations in tumor xenografts in nude mice. IDA Biomed. Res. 248–250.

    Google Scholar 

  5. Siddiqi, M.A., Hinkle, G.H., Hill, T.L., Mojziski, C.M., Olsen, J., Rousseau, M., Gersman, M., Houchens, D., Sardi, A., Thurston, M.O., and Martin, E.W., Jr. (1987) An assessment of prolonged reactivity of seven monoclonal antibodies against in situ cx-1 tumor xenografts using a novel hand-held gamma detecting probe. Invest. Surg., in press.

    Google Scholar 

  6. Goodwin, R.A., Tuttle, S.E., Bucci, D.M., Jewell, S.D., Martin, E.W., Jr., and Steplewski, Z. (1987) Tumor-associated antigen expression of primary and metastatic colon carcinomas detected by monoclonal antibody 17-1A. Am. J. Path., in press.

    Google Scholar 

  7. Oredipe, O.A., Barth, R.F., Tuttle, S.E., Adams, D.M., Sautins, I.E., Bucci, D.M., Mojzisik, C.M., Hinkle, G.H., Jewell, S.M., Steplewski, Z., Thurston, M.O., Martin, Jr., E.W. (1988) Limits of sensitivity for the radioimmunodetection of colon cancer by means of a hand held gamma probe. Nucl. Med. Biol. 15:595–603.

    CAS  Google Scholar 

  8. Martin, D.T., Hinkle, G.H., Tuttle, S., Olsen, J.O., Nabi, H., Houchens, D., Thurston, M., and Martin, E.W., Jr. (1985) Intraoperative radioimmunodetection of colorectal tumor with a hand-held radiation detector. Am. J. Surg. 150:672–675.

    Article  PubMed  CAS  Google Scholar 

  9. O’Dwyer, P.J., Mojzisik, C.M., Hinkle, G.H., Rousseau, M., Olsen, J., Tuttle, S.E., Barth, R.F., Thurston, M.O., McCabe, D.P., Farrar, W.B., and Martin, E.W., Jr. (1986) Intra-operative probe-directed radioimmunodetection using a monoclonal antibody. Arch. Surg. 121:1391–1394.

    PubMed  Google Scholar 

  10. Martin, E.W., Jr., Tuttle, S.E., Rousseau, M., Mojzisik, C.M., O’Dwyer, P.J., Hinkle, G.H., Miller, E.A., Goodwin, R.A., Oredipe, O.A., Barth, R.F., Olsen, J.O., Houchens, D., Jewell, S.D., Bucci, D.M., Adams, D., Steplewski, Z., and Thurston, M.O. (1986) Radioimmunoguided surgery: Intraoperative use of monoclonal antibody 17-1A in colorectal cancer. Hybridoma 5:S97–S108.

    PubMed  Google Scholar 

  11. Sickle-Santanello, B.J., O’Dwyer, P.J., Mojzisik, C.M., Tuttle, S.E., Hinkle, G.H., Rousseau, M., Schlom, J., Colcher, D., Thurston, M.O., Nieroda, C., Sardi, A., Farrar, W.B., Minton, J.P., and Martin, E.W., Jr. (1987) Radioimmunoguided surgery using the monoclonal antibody B72.3 in colorectal tumors. Dis. Colon Rectum 30:761–765.

    Article  PubMed  CAS  Google Scholar 

  12. DeLand, F.H., Kim, E.E., Primus, F.J., Dine, M.E., and Goldenberg, D.M. (1982) In vivo radioimmunodetection of occult recurrent colonic carcinoma. Am. J. Radiol. 138:145–148.

    CAS  Google Scholar 

  13. Mach, J.P., Carrel, S., Forni, M., Ritschard, J., Donath, A., and Alberto, P. (1986) Tumor localization of radiolabeled antibodies against carcinoembryonic antigen in patients with carcinoma: A critical evaluation. N. Engl. J. Med. 303:5–10.

    Article  Google Scholar 

  14. Colcher, D., Horan, H.P., Nuti, M., and Schlom, J. (1981) A spectrum of monoclonal antibodies reactive with human mammary tumor cells. Proc. Natl. Acad. Sci. USA 78: 3199–3203.

    Article  PubMed  CAS  Google Scholar 

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© 1990 Kluwer Academic Publishers

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Martin, E.W., Hinkle, G., Mojzisik, C., Thurston, M.O. (1990). Radioimmunoguided surgery: A new intraoperative approach to the detection of tumor. In: Goldenberg, D.M. (eds) Cancer Imaging with Radiolabeled Antibodies. Cancer Treatment and Research, vol 51. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1497-4_20

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  • DOI: https://doi.org/10.1007/978-1-4613-1497-4_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8805-3

  • Online ISBN: 978-1-4613-1497-4

  • eBook Packages: Springer Book Archive

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