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Antibody targeting: Theoretical considerations

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Cancer Imaging with Radiolabeled Antibodies

Part of the book series: Cancer Treatment and Research ((CTAR,volume 51))

Abstract

The detection of tumors using radiolabeled antibodies has been usefully applied to many tumor types [1]. Many important factors can be defined and thereby developed into mathematical models to assess the potential and limitations of the technique. This allows a clear understanding of the physical and biologic problems that need to be solved. At present fairly superficial lesions, between 1/2 and 1 cm in diameter, are likely to be detected with an optimal combination of attainable factors. Theoretically, for the majority of tumors, the technique is not significantly more sensitive than several other imaging methods.

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References

  1. Bradwell, A.R., Fairweather, D.S., Dykes, P.W., Keeling, A., Vaughan, A.T.M., and Taylor, J. (1985) Limiting factors in the localization of tumors with radiolabeled antibodies. Immunol. Today 6:163–170.

    Article  Google Scholar 

  2. Rockoff, S.D., Goodenough, D., and McIntire, K.R. (1980) Theoretical limitations in the immunodiagnostic imaging of cancer with computed tomography and nuclear scanning. Cancer Res. 40:3054–3058.

    PubMed  CAS  Google Scholar 

  3. Hedin, A., Wahren, B., and Hammerstrom, S. (1982) Tumor localization of CEA-containing human tumors in nude mice by means of monoclonal anti-CEA antibodies. Int. J. Cancer. 30:547–552.

    Article  PubMed  CAS  Google Scholar 

  4. Moshakis, V., Bailey, M.J., Ormerod, M.G., Westwood, J.H., and Neville. A.M. (1981) Localization of human breast-carcinoma xenografts using antibodies to carcinoembryonic antigen. Br. J. Cancer 43:575–581.

    Article  PubMed  CAS  Google Scholar 

  5. Goldenberg, D.M., DeLand, F.H., Kim, E., Bennett, S., Primus, F.J., van Nagell, J.R., Estes, N., DeSimone, P., and Rayburn, P. (1978) Use of radiolabeled antibodies to carcinoembryonic antigen for the detection and localization of diverse cancers by external photoscanning. N. Engl. J. Med. 298:1384–1388.

    Article  PubMed  CAS  Google Scholar 

  6. Goldenberg, D.M., Kim, E.E., DeLand, F.H., Van Nagell, J.R., and Javadpour, N. (1980) Clinical radioimmunodetection of cancer with radioactive antibodies to human chorionic gonadotrophin. Science 208:1284–1286.

    Article  PubMed  CAS  Google Scholar 

  7. Ghose, T., Norvell, S.T., Aquino, J., Belitsky, P., Tai, J., Guclu, A., and Blair, A.H. (1980) Localization of 131-I-labeled antibodies in human renal cell carcinomas and in a mouse hepatoma and correlation with tumor detection by photoscanning. Cancer Res. 40:3018–3031.

    PubMed  CAS  Google Scholar 

  8. Dykes, P.W., Hine, K.R., Bradwell, A.R., Blackburn, J.C., Reeder, T.A., Drolc, Z., and Booth, S.N. (1980) Localization of tumor deposits by external scanning after injection of radiolabeled anti-carcinoembryonic antigen. Br. Med. J. 280:220–222.

    Article  PubMed  CAS  Google Scholar 

  9. Mach, J-P., Carrel, S., Forni, M., Ritschard, J., Donath, A., and Alberto, P. (1980) Tumor localization of radiolabeled antibodies against carcinoembryonic antigen in patients with carcinoma. N. Engl. J. Med. 303:5–10.

    Article  PubMed  CAS  Google Scholar 

  10. Mach, J-P., Buchegger, F., Forni, M., Ritschard, J., Berche, C, Lumbroso, J.D., Schreyer, M. Giardet, C., Accolla, R.D. and Carrel, S. (1981) Use of radiolabeled monoclonal anti-CEA antibodies for the detection of human carcinomas by external photoscanning and tomoscintigraphy. Immunol. Today 2:239–249.

    Article  Google Scholar 

  11. Farrands, P.A., Perkins. A.C., Pimm, M.V., Hardy, J.D., Embleton, M.J., Baldwin, R.W., and Hardcastle, J.D. (1982) Radioimmunodetection of human colorectal cancers by an anti-tumor monoclonal antibody. Lancet 2:398–400.

    Google Scholar 

  12. Ishii, N., Nakata, K., Munehisa, T., Koji, T., Nishi, S., and Hirai, H. (1983) Radioimmunodetection of cancer using radiolabeled antibodies to alphafetoprotein. Prot. Biol. Fluids. 31:305–308.

    Google Scholar 

  13. Mach, J-P., Chatal, J.F., Lumbroso, J.D., Buchegger, F., Forni, M., Ritschard, J., Berche, C., Douillard, J-Y., Carrel, S., Herlyn, M., Steplewski, Z., and Koprowski, H. (1983) Tumor localization in patients by radiolabeled monoclonal antibodies against colon carcinoma. Cancer Res. 43:5593–5600.

    PubMed  CAS  Google Scholar 

  14. Larson, S.M., Brown, J.P., Wright, P.W., Carrasquillo, J.A., Hellstrom, I, and Hellstrom, K.E. (1983) Imaging of melanoma with I-131-labeled monoclonal antibodies. J. Nucl. Med. 24:123–129.

    PubMed  CAS  Google Scholar 

  15. Rainsbury, R.M., Ott, R.J., Westwood, J.H., Kalirai, T.S., Coombes, R.C., McCready, V.R., Neville, A.M., and Gazet, J-C. (1983) Location of metastatic breast carcinoma by a monoclonal antibody chelate labelled with indium-III. Lancet 2:934–938.

    Article  PubMed  CAS  Google Scholar 

  16. Armitage, N.C., Perkins, A.C., Pimm, M.V., Farrands, P.A., Baldwin, R.W., and Hardcastle, J.D. (1984) The localization of an anti-tumor monoclonal antibody (791T/36) in gastrointestinal tumors. Br. J. Surg. 71:407–412.

    Article  PubMed  CAS  Google Scholar 

  17. Chatal, J.F., Saccavini, J.C., Fumoleau, P., Douillard, J-Y., Curtet, C., Kremer, M., LeMevel, B.Q., and Koprowski, H. (1984) Immunoscintigraphy of colon carcinoma. J. Nucl. Med. 25:307–314.

    PubMed  CAS  Google Scholar 

  18. Thompson, C.H., Lichtenstein, M., Stacker, S.A., Leyden, M.J., Salehi, N., Andrews, J.T., and McKenzie, I.F.C. (1984) Immunoscintigraphy for detection of lymph node metastases from breast cancer. Lancet 2:1245–1247.

    Article  PubMed  CAS  Google Scholar 

  19. Buraggi, G.L., Callegaro, L., Mariani, G., Turrin, A., Cascinelli, N., Attili, A., Bombardieri, E., Terno, G., Plassio, G., Dovis, M., Mazzuca, N., Natali, P.G., Scassallati, G.A., Rosa, U., and Ferrone, S. (1985) Imaging with I-131 labeled monoclonal antibodies to a high-molecular-weight melanoma-associated antigen in patients with melanoma: Efficacy of whole immunoglobulin and its F(ab′)2 fragments. Cancer Res. 45:3378–3387.

    PubMed  CAS  Google Scholar 

  20. Epenetos, A.A., Carr, D., Johnson, P.M., Bodmer, W.F., and Lavender, J.P. (1986) Antibody guided radiolocalization of tumors in patients with testicular or ovarian cancer using two radioiodinated monoclonal antibodies to placental alkaline phosphatase. Br. J. Radiol. 59:117–125.

    Article  PubMed  CAS  Google Scholar 

  21. Epenetos, A.A., Snook, D., Durban, H., Johnson, P.M., and Taylor-Papadimitriou, J. (1986) Limitations of radiolabeled monoclonal antibodies for localization of human neoplasms. Cancer Res. 46:3183–3191.

    PubMed  CAS  Google Scholar 

  22. Armitage, N.C., Perkins, A.C., Pimm, M.V., Wastie, M., Hopkins, J.S., Dowling, F., Baldwin, R.W., and Hardcastle, J.D. (1986) Imaging of bone tumors using a monoclonal antibody raised against human osteosarcoma. Cancer 58:37–42.

    Article  PubMed  CAS  Google Scholar 

  23. Begent, R.H.J., Keep, P.A., Green, A.J., Searle, F., Bagshawe, K.D., Jewkes, R.F., Jones, B.E., Barratt, G.M. and Ryman, B.E. (1982) Liposomally entrapped second antibody improves tumor imaging with radiolabeled (first) anti-tumor antibody. Lancet 2:739–742.

    Article  PubMed  CAS  Google Scholar 

  24. Mach, J-P., Forni, M., Ritschard, J., Buchegger, F., Carrel, S., Widgren, S., Donath, A., and Alberto, P. (1980) Use and limitations of radiolabeled anti-CEA antibodies and their fragments for photoscanning detection of human colorectal carcinomas. Oncol. Dev. Biol. Med. 1:49–69.

    CAS  Google Scholar 

  25. Keeling, A.A., Bradwell, A.R., Fairweather, D.S., Dykes, P.W., and Vaughan, A. (1984) Characteristics of first and second antibodies for tumor imaging. Prot. Biol. Fluids. 32: 455–457.

    CAS  Google Scholar 

  26. Haskell, C.M., Buchegger, F., Schreyer, M., Carrel, S., and Mach, J.P. (1983) Monoclonal antibodies to carcinoembryonic antigen: Ionic strength as a factor in the selection of antibodies for immunoscintigraphy. Cancer Res. 43:3857–3864.

    PubMed  CAS  Google Scholar 

  27. Nose, M., and Wigzell, H. (1983) Biological significance of carbohydrate chains on monoclonal antibodies. Proc. Natl. Acad. Sci. USA 80:6632–6636.

    Article  PubMed  CAS  Google Scholar 

  28. Greenwood, F.C., Hunter, W.M., and Glover, J.S. (1963) The preparation of 131-I-labeled human growth hormone of high specific radioactivity. Biochem. J. 89:114–123.

    PubMed  CAS  Google Scholar 

  29. Fairweather, D.S., Bradwell, A.R., Dykes, P.W., Vaughan, A.T., Watson-James, S.F., and Chandler, S. (1983) Improved tumor localization using indium-111 labeled antibodies. Br. Med. J. 287:167–170.

    Article  CAS  Google Scholar 

  30. Hnatowich, D.J., Layne, W.W., Childs, R.L., Lanteigne, D., Davis, M.A., Griffin, T.W., and Doherty, P.W. (1983) Radioactive labelling of antibody: A simple and efficient method. Science 220:613–615.

    Article  PubMed  CAS  Google Scholar 

  31. Hnatowich, D.J., Layne, W.W., and Childs, R.L. (1982) The preparation and labelling of DTDA-coupled albumin. Int. J. Appl. Radat. Isot. 33:327–332.

    Article  CAS  Google Scholar 

  32. Goodwin, D., Meares, C., Diamanti, C., McCall, M., Lai, X., Torti, F., McTigue, M., and Martin, B. (1984). Use of specific antibody for rapid clearance of circulating blood background from radiolabeled tumor imaging proteins. Eur. J. Nucl. Med. 9:209–215.

    Article  PubMed  CAS  Google Scholar 

  33. Nadler, L.M., Stashenko, P., Hardy, R., Kaplan, W.D., Button, L.N., Kufe, D.W., Antman, K.H., and Schlossman, S.F. (1980) Serotherapy of a patient with a monoclonal antibody directed against a human lymphoma-associated antigen. Cancer Res. 40:3147–3154.

    PubMed  CAS  Google Scholar 

  34. Meeker, T.C., Lowder, J., Maloney, D.G., Miller, R.A., Thielemans, K., Warnke, R., and Levy, R. (1985) A clinical trial of anti-idiotype therapy for B cell malignancy. Blood 65:1349–1363.

    PubMed  CAS  Google Scholar 

  35. Gerlowski, L.E., and Jain, R.K. (1986) Microvascular permeability of normal and neoplastic tissues. Microvasc. Res. 31:288–305.

    Article  PubMed  CAS  Google Scholar 

  36. Epenetos, A.A., Britton, K.E., Mather, S., Shepherd, J., Granowska, M., Taylor-Papadimitriou, J., Nimmon, C.C., Durbin, H., Hawkins, L.R., Malpas, J., and Bodmer, W.F. (1982) Targeting of iodine-123-labelled tumor-associated monoclonal antibodies to ovarian, breast, and gastrointestinal tumors. Lancet 2:999–1005.

    Article  PubMed  CAS  Google Scholar 

  37. Morrison, R.T., Lyster, D.M., Alcorn, L., Rhodes, B.A., Breslow, K., and Burchiel, S.W. (1984) Radioimmunoimaging with 99mTc monoclonal antibodies: Clinical studies. Int. J. Nucl. Med. Biol. 11:184–188.

    Article  PubMed  CAS  Google Scholar 

  38. Berche, C., Mach, J-P., Lumbroso, J.D., Langlais, C., Aubrey, F., Buchegger, F., Carrel, S., Rougier, P., Parmentier, C., and Tubiana, M. (1982) Tomoscintigraphy for detecting gastrointestinal and medullary thyroid cancers: First clinical results using carcinoembryonic antigen. Br. Med. J. 285:1447–1451.

    Article  CAS  Google Scholar 

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Authors
  1. Arthur Bradwell
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  2. Peter Dykes
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  3. Gillian Thomas
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Editor information

Editors and Affiliations

  1. Center for Molecular Medicine and Immunology, University of Medicine and Dentistry of New Jersey, 1 Bruce St., Newark, New Jersey, 07103, USA

    David M. Goldenberg Sc.D., M.D.

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© 1990 Kluwer Academic Publishers

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Bradwell, A., Dykes, P., Thomas, G. (1990). Antibody targeting: Theoretical considerations. In: Goldenberg, D.M. (eds) Cancer Imaging with Radiolabeled Antibodies. Cancer Treatment and Research, vol 51. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1497-4_2

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  • DOI: https://doi.org/10.1007/978-1-4613-1497-4_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8805-3

  • Online ISBN: 978-1-4613-1497-4

  • eBook Packages: Springer Book Archive

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