Skip to main content
SpringerLink
Log in

Antibody lymphoscintigraphy

  • Chapter
Cancer Imaging with Radiolabeled Antibodies

Part of the book series: Cancer Treatment and Research ((CTAR,volume 51))

Abstract

The term antibody lymphoscintigraphy as used here encompasses two techniques: 1) direct injection into cannulated lymphatic vessels, as was first performed by Order and his coworkers using polyclonal anti-ferritin preparations [1,2], and 2) injection into an interstitial space for uptake by the lymphatic capillaries, as was pioneered by DeLand, Goldenberg, et al. [3,4] using a polyclonal antibody directed against carcinoembryonic antigen. This chapter focuses on animal model studies of antibody lymphoscintigraphy, with only a brief description of the clinical experience. Clinical studies are covered in extenso by DeLand elsewhere in this volume.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Order, S.E., Bloomer, W.D., Jones, A.G, Kaplan, W.D., Davis, M.A., Adelstein, S.J., and Hellman, S. (1975) Radionuclide immunoglobulin lymphangiography: A case report. Cancer 35:1487–1492.

    Article  PubMed  CAS  Google Scholar 

  2. Order, S.E. (1977) Immunospecific radionuclide immunoglobulin lymphography. In: Clouse, M.E. (ed.), Clinical Lymphography, Vol. 7. Baltimore: Williams and Wilkins, pp. 316–322.

    Google Scholar 

  3. DeLand, F.H., Kim, E.E., Corgan, R.L., Casper, S., Primus, F.J., Spremulli, E., Estes, N., and Goldenberg, D.M. (1979) Axillary lymphoscintigraphy by radioimmunodetection of carcinoembryonic antigen in breast cancer. J. Nucl. Med. 20:1243–1250.

    Google Scholar 

  4. DeLand, F.H., Kim, E.E., and Goldenberg, D.M. (1980) Lymphoscintigraphy with radio-nuclide-labeled antibodies to carcinoembryonic antigen. Cancer Res. 40:2997–3000.

    PubMed  CAS  Google Scholar 

  5. Hellman, S., Harris, J.R., Canellos, G.P., and Fisher, B. (1982) Cancer of the breast. In: De Vita, V.T., Jr., Hellman, S., and Rosenberg, S.A. (eds.), Cancer, Principles and Practice of Oncology. Philadelphia: JB Lippincott, pp. 914–970.

    Google Scholar 

  6. Haagensen, C.D. (1977) Int. J. Rad. Oncol. Biol. Phys. 2:975–980.

    Article  CAS  Google Scholar 

  7. Fisher, B., Wolmark, N., Redmond, C., Deutsch, M., and Fisher, E.R. (1981) Cancer 48: 1863–1872.

    Article  PubMed  CAS  Google Scholar 

  8. Ege, G.N. (1976) Internal mammary lymphoscintigraphy. Radiology 118:101–107.

    PubMed  CAS  Google Scholar 

  9. Ege, G.N. (1983) Lymphoscintigraphy — Techniques and applications in the management of breast cancer. Semin. Nucl. Med. 13:26–34.

    Article  PubMed  CAS  Google Scholar 

  10. Kaplan, W.D. (1983) Iliopelvic lymphoscintigraphy. Semin. Nucl. Med. 13:42–53.

    Article  PubMed  CAS  Google Scholar 

  11. Weinstein, J.N., Keenan, A.M., Holton, O.D., III, Covell, D.G., Sieber, S.M., Black, C.D.V., Barbet, J., and Parker, R.J. (1985) Use of monoclonal antibodies to detect metastases of solid tumors in lymph nodes. In: Ceriani, R.L. (ed.), Monoclonal and Breast Cancer. Boston: Martinus Nijhoff, pp. 218–232.

    Google Scholar 

  12. Yoffey, J.M., and Courtice, F.C. (1970) Lymphatics, Lymph and the Lymphomyeloid Complex. London: Academic Press, pp. 1–942.

    Google Scholar 

  13. Leak, L.V. (1971) Studies on the permeability of lymphatic capillaries. J. Cell Biol. 50: 300–323.

    Article  PubMed  CAS  Google Scholar 

  14. Barsky, S.H., Baker, A., Siegal, G.P., Togo, S., and Liotta, L.A. (1983) Use of anti-basement membrane antibodies to distinguish blood vessel capillaries from lymphatic capillaries. Am. J. Surg. Pathol. 7:667–677.

    Article  PubMed  CAS  Google Scholar 

  15. Weinstein, J.N., Parker, R.J., Keenan, A.M., Dower, S.K., Morse, H.C., 3rd, and Sieber, S.M. (1982) Monoclonal antibodies in the lymphatics: Toward the diagnosis and therapy of tumor metastases. Science 218:1334–1337.

    Article  PubMed  CAS  Google Scholar 

  16. Sachs, D.H., Mayer, N., and Ozato, K. (1981) In: Hammerling, U., and Kearney, J.F. (eds.), Monoclonal Antibodies and T-Cell Hybridomas. Amsterdam: Elsevier/North-Holland Press, pp. 95–101.

    Google Scholar 

  17. Steiler, M.A., Parker, R.J., Covell, D.G., Holton, O.D., III, Keenan, A.M., Sieber, S.M., and Weinstein, J.N. (1986) Optimization of monoclonal antibody delivery via the lymphatics: The dose-dependence. Cancer Res. 46:1830–1834.

    Google Scholar 

  18. Parker, R.J., Weinstein, J.N., Keenan, A.M., Dower, S.K., Steiler, M.A., Holton, O.D., and Sieber, S.M. (1987) Targeting of radiolabeled monoclonal antibodies in the lymphatics. Cancer Res. 47:2073–2076.

    PubMed  CAS  Google Scholar 

  19. Weinstein, J.N., Steller, M.A., Covell, D.G., Holton, O.D., III, Keenan, A.M., Sieber, S.M., and Parker, R.J. (1984) Monoclonal anti-tumor antibodies in the lymphatics. Cancer Treat. Rep. 68:257–264.

    PubMed  CAS  Google Scholar 

  20. Keenan, A.M., Weinstein, J.N., Mulshine, J.L., Carrasquillo, J.A., Bunn, P.A., Jr., Reynolds, J.C., Foon, K.A., Perentesis, P., Ghosh, B., and Larson, S.M. (1987) Evaluation of lymphoma by immunolymphoscintigraphy: Subcutaneous injection of indium-111-labeled T101 monoclonal antibody. J. Nucl. Med. 28:42–46.

    PubMed  CAS  Google Scholar 

  21. Keenan, A.M., Weinstein, J.N., Carrasquillo, J.A., Bunn, P.A., Jr., Reynolds, J.C., Foon, K.A., Smarte, N.C., Ghosh, B., Fejka, R.M., Larson, S.M., and Mulshine, J.L. (1987) Immunolymphoscintigraphy and the dose dependence of 111In-labeled T101 monoclonal antibody in patients with cutaneous T-cell lymphoma. Cancer Res. 47:6093–6099.

    PubMed  CAS  Google Scholar 

  22. Weinstein, J.N., Steller, M.A., Covell, D.G., Dower, S.K., Segal, D.M., Keenan, A.M., Sieber, S.M., and Parker, R.J. (1983) Use of monoclonal antibodies for diagnosis and therapy of tumor metastases in lymph nodes. In: Chaiken, I.M., Wilchek, M., and Parikh, I. (eds.), Affinity Chromatography and Biological Recognition. New York: Academic Press, pp. 337–342.

    Google Scholar 

  23. Covell, D.G., Steiler, M.A., Parker, R.J., and Weinstein, J.N. (1985) Delivery of monoclonal antibodies through the lymphatics: Characterization by compartmental modeling. Comp. Applica. Med. Care 10:884–888.

    Google Scholar 

  24. Halpern, S.E., Hagan, P.L., Bartholomew, R.M., Frincke, J.M., Poggenburg, J.K., Merchant, E.B., and Carlo, D.J. (1986) Kinetics and distribution of subcutaneously administered 111-In IgG and IgM antibodies (A) in a mouse model (abstract). J. Nucl. Med. 27: 902.

    Google Scholar 

  25. Black,C.D.V., Atcher, J.B., Brechbiel,M.W.,Holton,O.D., III, Hines, J.J., Gansow, O.A., and Weinstein, J.N. (1988) Selective ablation of B lymphocytes in vivo by an alpha emitter, 212Bismuth, chelated to a monoclonal antibody. Antibody, Immunoconju. Radiopharma. 1:43–53.

    CAS  Google Scholar 

  26. Brechbiel, M.W., Gansow, O.A., Atcher, R.W., Schlom, J., Esteban, J., Simpson, D.E., and Colcher, D. (1986) Inorg. Chem. 25:2772.

    Article  CAS  Google Scholar 

  27. Wahl, R.L., Geatti, O., Liebert, M., Wilson, B., Shreve, P., and Beers, B.A. (1987) Kinetics of interstitially administered monoclonal antibodies for purposes of lymphoscintigraphy. J. Nucl. Med. 28:1736–1744.

    PubMed  CAS  Google Scholar 

  28. Wahl, R.L., Fisher, S., and Petry, N.A. (1986) Antibodies, albumin and antimony: Comparison of three lymphoscintigraphic agents. Radiology 161:322.

    Google Scholar 

  29. Wahl, R.L., Liebert, M., Wilson, B.S., and Petry, N.A. (1988) Radiolabeled antibodies, albumin and antimony sulfide colloid: A comparison as lymphoscintigraphic agents. Nucl. Med. Biol. 15:243–250.

    CAS  Google Scholar 

  30. Wahl, R.L., Laino, L., Fisher, S., Schteingart, M., and Beierwaltes, W.H. (1988) Improved radioimmunolocalization of human tumor xenografts following subcutaneous delivery of monoclonal antibodies. Eur. J. Nucl. Med. 13:530–536.

    Article  PubMed  CAS  Google Scholar 

  31. Key, M.E., Bernhard, M.I., Hoyer, L.C., et al. (1983) Guinea pig line 10 hepatocarcinoma model for monoclonal antibody serotherapy II. In vivo localization of a monoclonal antibody in normal and malignant tissues. J. Immunol. 130:1451–1457.

    PubMed  CAS  Google Scholar 

  32. Bernhard, M.I., Hwang, K.M., Foon, K.A., et al. (1983) Localization of 111indium and 131iodine labeled monoclonal antibody in guinea pigs bearing line 10 hepatocarcinoma tumors. Cancer Res. 43:4429–4433.

    PubMed  CAS  Google Scholar 

  33. Weinstein, J.N., Steller, M.A., Keenan, A.M., Covell, D.G., Key, M.E., Sieber, S.M., Oldham, R.K., Hwang, K.M., and Parker, R.J. (1983) Monoclonal antibodies in the lymphatics: Selective delivery to lymph node metastases of a solid tumor. Science 222: 423–427.

    Article  PubMed  CAS  Google Scholar 

  34. Weinstein, J.N., Keenan, A.M., Holton, O.D., III, Covell, D.G., Sieber, S.M., Black, C.D.V., Barbet, J., and Parker, R.J. (1985) Use of monoclonal antibodies to detect metastases of solid tumors in lymph nodes. In: Ceriani, R.L. (ed.), Monoclonal Antibodies and Breast Cancer. Boston: Martinus Nijhoff, pp. 218–232.

    Google Scholar 

  35. Weinstein, J.N., Black, C.D.V., Barbet, J., Eger, R.R., Parker, R.J., Holton, O.D., III, Mulshine, J.L., Keenan, A.M., Larson, S.M., Carrasquillo, J.A., Sieber, S.M., and Covell, D.G. (1986) Selected issues in the pharmacology of monoclonal antibodies. In: Tomlinson, E., and Davis, S.S. (eds.), Site-Specific Drug Delivery: Cell Biology, Medicinal and Pharmaceutical Aspects. New York: John Wiley, pp. 81–91.

    Google Scholar 

  36. Covell, D.G., Barbet, J., Holton, O.D., III, Black, C.V.D., Keenan, A.M., Sieber, S.M., and Weinstein, J.N. Global and local factors in the pharmacology of monoclonal antibodies. Ame. Statist. Soc. Sympos., in press.

    Google Scholar 

  37. Weinstein, J.N., Black, C.D.V., Keenan, A.M., Holton, O.D., III, Larson, S.M., Sieber, S.M., Covell, D.G., Carrasquillo, J., Barbet, J., and Parker, R.J. (1986) Use of monoclonal antibodies for detection of lymph node metastases. In: Reisfeld, R.A., and Sell, S. (eds.), Monoclonal Antibodies in Cancer Therapy. New York: Alan R. Liss, pp. 473–488.

    Google Scholar 

  38. Mulshine, J.L., Keenan, A.M., Carrasquillo, J.A., Walsh, T., Linnoila, R.L, Holton, O.D., Harwell, J., Larson, S.M., Bunn, P.A., and Weinstein, J.N. (1987) Immunoscintigraphy of pulmonary and mediastinal lymph nodes: A new approach to lung cancer imaging. Cancer Res. 47:3572–3576.

    PubMed  CAS  Google Scholar 

  39. Watanabe, M., Suzuki, T., Taniguchi, M., and Shinohara, N. (1983) Monoclonal anti-Ia murine alio antibodies cross reactive with the Ia-homologies of other mammalian species including humans. Transplantation 36:712–718.

    Article  PubMed  CAS  Google Scholar 

  40. Thompson, C.H., Stacker, S.A., Salehi, N., Lichtenstein, M., Leyden, M.J., Andrews, J.T., and McKenzie, I.F.C. (1984) Immunoscintigraphy for detection of lymph node metastases from breast cancer. Lancet 2:1245–1247.

    Article  PubMed  CAS  Google Scholar 

  41. Veronesi, U., Adamus, J., Bandiera, D.C., Brennhovd, I.O., Caceres, E., Cascinelli, N., Claudio, F., Ikonopisov, R.L., Javorskj, V.V., Kirov, S., Kulakowski, A., Lacour, J., Lejeune, F., Mechl, Z., Morabito, A., Rode, I., Sergeev, S., van Slooten, E., Szczygiel, K., Trapeznikov, N.N., and Wagner, R.L (1977) Stage I melanoma of the limbs: Immediate versus delayed node dissection. N. Engl. J. Med. 297:627.

    Article  PubMed  CAS  Google Scholar 

  42. Balch, C.M., Cascinelli, N., Milton, G.W., and Sim, F.H. (1985) Elective lymph node dissection. In: Balch, CM., and Milton, G.W. (eds.), Cutaneous Melanoma. Philadelphia: J.B. Lippincott, pp. 131–157.

    Google Scholar 

  43. Lotze, M.T., Carrasquillo, J.A., Weinstein, J.N., Bryant, G.J., Perentesis, P., Reynolds, J.C., Matis, L.A., Eger, R.R., Keenan, A.M., Hellstrom, I., Hellstrom, K.-E., and Larson, S.M. (1986) Monoclonal antibody imaging of human melanoma: Radioimmunodetection by subcutaneous or systemic injection. Ann. Surg. 204:223–235.

    Article  PubMed  CAS  Google Scholar 

  44. Nelp, W.B., Eary, J.F., Jones, R.F., Kishore, R., Krohn, K.A., Beaumier, P.L., Hellstrom, K.-E., and Hellstrom, I. (1986) Preliminary studies of radiolabeled monoclonal antibody lymphoscintigraphy in malignant melanoma. J. Nucl. Med. 26:66.

    Google Scholar 

  45. Royston, I., Majda, J.A., and Baird, S.M., et al. (1980) Human T cell antigens defined by monoclonal antibodies: The 65,000-dalton antigen of T cells (T65) is also found on chronic lymphocytic leukemia cells bearing surface immunoglobulin. J. Immunol. 125:725–731.

    PubMed  CAS  Google Scholar 

  46. Weinstein, J.N., Parker, R.J., Holton, O.D., III, Keenan, A.M., Covell, D.G., Black, C.D.V., and Sieber, S.M. (1985) Lymphatic delivery of monoclonal antibodies: Potential for detection and treatment of lymph node metastases. Cancer Invest. 3:85–95.

    Article  PubMed  CAS  Google Scholar 

  47. Weinstein, J.N., Holton, O.D., III, Black, C.D.V., Covell, D.G., Spaulding, G.F., Barbet, J., Steiler, M.A., Sieber, S.M., Talley, M.J., and Parker, R.J. (1986) Regional delivery of monoclonal antitumor antibodies: Detection and possible treatment of lymph node metastases. In: Welch, D.R., Bhuyan, B.K., and Liotta, L.A. (eds.), Cancer Metastasis: Experimental and Clinical Strategies. New York: Alan R. Liss, pp. 169–180.

    Google Scholar 

  48. Weinstein, J.N., Eger, R.R., Covell, D.G., Black, C.D.V., Mulshine, J., Carrasquillo, J.A., Larson, S.M., and Keenan, A.M. (1987) The pharmacology of monoclonal antibodies. Ann. NY Acad. Sci. 507:199–210.

    Article  PubMed  CAS  Google Scholar 

  49. Weinstein, J.N., Black, C.D.V., Holton, O.D., III, Covell, D.G., Parker, R.J., Mulshine, J.L., Lotze, M.T., Carrasquillo, J., Eger, R.R., Lewis, A., Larson, S.M., and Keenan, A.M. (1987) Delivery of monoclonal antibodies to lymph nodes via the lymphatics. In: Winkelhake, J.L., and Holcenberg, J.S. (eds.), The Pharmacology and Toxicology of Proteins. New York: Alan R. Liss, pp. 75–89.

    Google Scholar 

  50. Larson, S.M., Brown, J.P., Wright, P.W., et al. (1983) Localization of 131I-labeled p97-specific Fab fragments in human melanoma as a basis for radiotherapy. J. Nucl. Med. 24: 123–129.

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. John N. Weinstein
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Center for Molecular Medicine and Immunology, University of Medicine and Dentistry of New Jersey, 1 Bruce St., Newark, New Jersey, 07103, USA

    David M. Goldenberg Sc.D., M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Kluwer Academic Publishers

About this chapter

Cite this chapter

Weinstein, J.N. (1990). Antibody lymphoscintigraphy. In: Goldenberg, D.M. (eds) Cancer Imaging with Radiolabeled Antibodies. Cancer Treatment and Research, vol 51. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1497-4_19

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1497-4_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8805-3

  • Online ISBN: 978-1-4613-1497-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation