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Diversity of the human immune response to clinically used murine monoclonal antibodies

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Cancer Imaging with Radiolabeled Antibodies

Part of the book series: Cancer Treatment and Research ((CTAR,volume 51))

Abstract

Murine monoclonal antibodies raised to tumor-associated antigens [1–4] and lymphoid cell receptors [5,6] have been used in clinical trials since 1980. A major complication to their use was thought to be the patient’s immune response to these xenogeneic proteins. Such immune responses or hypersensitivity reactions could result in anaphylaxis and abrogation of the antibodies’ clinical efficacy.

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Authors
  1. Nigel S. Courtenay-Luck
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  2. Agamemnon A. Epenetos
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Editor information

Editors and Affiliations

  1. Center for Molecular Medicine and Immunology, University of Medicine and Dentistry of New Jersey, 1 Bruce St., Newark, New Jersey, 07103, USA

    David M. Goldenberg Sc.D., M.D.

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© 1990 Kluwer Academic Publishers

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Courtenay-Luck, N.S., Epenetos, A.A. (1990). Diversity of the human immune response to clinically used murine monoclonal antibodies. In: Goldenberg, D.M. (eds) Cancer Imaging with Radiolabeled Antibodies. Cancer Treatment and Research, vol 51. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1497-4_18

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  • DOI: https://doi.org/10.1007/978-1-4613-1497-4_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8805-3

  • Online ISBN: 978-1-4613-1497-4

  • eBook Packages: Springer Book Archive

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