Initial Statistical Considerations

  • B. G. White
Part of the Foundations of Neurology book series (FONY, volume 1)


In the second half of the twentieth century, through their pioneering work in clinical trial and statistical methodology, individuals such as Sir A.B. Hill in the United Kingdom and J. Cornfield in the United States ushered in the randomized controlled clinical trial, a major advance in clinical medicine. Clearly, however, the comparative clinical experiment dates from much earlier; the Book of Daniel describes a comparative trial of two diets [2]. Several authors have reviewed the development of the modern clinical investigation from a statistical viewpoint [3, 4].


Neurologic Disease Randomization Scheme Inadequate Sample Size Adaptive Randomization High Clinical Relevance 
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© Kluwer Academic Publishers 1990

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  • B. G. White

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